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5-fluorouracil Improves the Testicular Antioxidant Status and Alleviates Oxidative Stress in Male Albino Rats Treated with Cyclophosphamide

World Journal of Cancer and Oncology Research | Vol 1, Issue 1

Table 2. Testes TBARS, glutathione and Testesnitric oxide of rat treated with cyclophosphamide and/or 5-fluorouracil

Groups

Parameters

Control

CPA

5-FU

CPA – 5-FU

Mean±SE

Mean±SE

Mean±SE

Mean±SE

Testes TBARS (U/g tissue)

2.87±0.49 bcd

10.78±0.64acd

8.08±0.84abd

5.09±0.74abc

Testes nitric oxide (U/g tissue)

443.6±57.14 bd

727.2±35.63 acd

460.8±132.26 bd

558.4±61.51 abc

Significance at P > 0.05. CPA: cyclophosphamide; 5-FU: Fluorouracil, a Comparison of control and other groups; b Comparison of CPA and other groups; c Comparison of 5-FU and other groups; d Comparison of CPA – 5-FU and other groups