The Role of Type 3 Diabetes in Alzheimer’s Disease: A Review of Current Evidence

Table 1. Eligibility Criteria

Criteria	Inclusion	Exclusion
Language	All articles published in English.	Non-English articles and publications.
Publication Date	Articles published within the last 10 years (2014–2024).	Articles published more than 10 years ago.
Peer Review	Articles and publications that are peer-reviewed.	Articles and publications that are not peer-reviewed, news articles, editorials, letters, and commentaries.
Focus on Diabetes	Patients diagnosed with Diabetes.	Patients not diagnosed with Diabetes.
Focus on Alzheimer’s Disease	Patients diagnosed with Alzheimer’s Disease (AD).	Patients not diagnosed with Alzheimer’s Disease (AD).
Age Range	Patients in age ranges typically associated with the onset and progression of T2DM and AD (middle-aged to elderly).	Not applicable or not meeting the age-related criteria for T2DM and AD.
Study Focus	Articles investigating the concept of “Type 3 Diabetes” in relation to AD.	Articles addressing AD with other neurological/psychiatric conditions (e.g., schizophrenia, bipolar, TBI).
Comorbidities	N/A	Patients with severe comorbidities (e.g., ESRD, CHF, active malignancies).
Medication Use	N/A	Patients using medications affecting cognition or glucose regulation (e.g., antidepressants, glucocorticoids).
General Criteria	Articles that meet all inclusion criteria.	Articles that do not meet the inclusion criteria.