@Article{crph6068,
AUTHOR = {Dagus, Mary Miliza and Lacambra, Vanessa and Magalona, Judith and Narvaez, Roison Andro and Paredes, Myra Katrina},
TITLE = {The Role of Type 3 Diabetes in Alzheimer’s Disease: A Review of Current Evidence},
JOURNAL = {Current Research in Public Health},
VOLUME = {4},
YEAR = {2025},
NUMBER = {1},
PAGES = {47-64},
URL = {https://www.scipublications.com/journal/index.php/WJNR/article/view/6068},
ISSN = {2831-5162},
DOI = {10.31586/wjnr.2025.6068},
ABSTRACT = {Background: Type 2 Diabetes Mellitus (T2DM) and Alzheimer’s Disease (AD) are increasingly linked through shared pathophysiological mechanisms, giving rise to the concept of Type 3 Diabetes Mellitus (T3DM). Brain insulin resistance, oxidative stress, and neuroinflammation are central to both conditions, contributing to cognitive decline and AD progression. Aim: This review aims to explore this emerging relationship and its implications for prevention and management. Methods: Using an integrative review, 21 studies were systematically analyzed. The review focused on identifying demographic, genetic, and lifestyle factors contributing to T2DM and AD and examined shared molecular pathways such as insulin dysregulation and amyloid-beta accumulation. Results: The findings reveal that T3DM shares key features with T2DM and AD, including insulin resistance and chronic inflammation. Lifestyle interventions, such as diet and exercise, alongside routine cognitive and metabolic screenings, are critical in mitigating progression. Conclusions: Further research into diagnostic biomarkers and targeted therapies is essential to manage T3DM and its impact on AD. The role of nursing professionals in early detection, education, and holistic management is emphasized as vital in addressing this dual disease burden. This review offers actionable insights into integrated strategies for addressing these interconnected conditions.},
}

%0 Journal Article
%A Dagus, Mary Miliza
%A Lacambra, Vanessa
%A Magalona, Judith
%A Narvaez, Roison Andro
%A Paredes, Myra Katrina
%D 2025
%J Current Research in Public Health

%@ 2831-5162
%V 4
%N 1
%P 47-64

%T The Role of Type 3 Diabetes in Alzheimer’s Disease: A Review of Current Evidence
%M doi:10.31586/wjnr.2025.6068
%U https://www.scipublications.com/journal/index.php/WJNR/article/view/6068

TY  - JOUR
AU  - Dagus, Mary Miliza
AU  - Lacambra, Vanessa
AU  - Magalona, Judith
AU  - Narvaez, Roison Andro
AU  - Paredes, Myra Katrina
TI  - The Role of Type 3 Diabetes in Alzheimer’s Disease: A Review of Current Evidence
T2  - Current Research in Public Health
PY  - 2025
VL  - 4
IS  - 1
SN  - 2831-5162
SP  - 47
EP  - 64
UR  - https://www.scipublications.com/journal/index.php/WJNR/article/view/6068
AB  - Background: Type 2 Diabetes Mellitus (T2DM) and Alzheimer’s Disease (AD) are increasingly linked through shared pathophysiological mechanisms, giving rise to the concept of Type 3 Diabetes Mellitus (T3DM). Brain insulin resistance, oxidative stress, and neuroinflammation are central to both conditions, contributing to cognitive decline and AD progression. Aim: This review aims to explore this emerging relationship and its implications for prevention and management. Methods: Using an integrative review, 21 studies were systematically analyzed. The review focused on identifying demographic, genetic, and lifestyle factors contributing to T2DM and AD and examined shared molecular pathways such as insulin dysregulation and amyloid-beta accumulation. Results: The findings reveal that T3DM shares key features with T2DM and AD, including insulin resistance and chronic inflammation. Lifestyle interventions, such as diet and exercise, alongside routine cognitive and metabolic screenings, are critical in mitigating progression. Conclusions: Further research into diagnostic biomarkers and targeted therapies is essential to manage T3DM and its impact on AD. The role of nursing professionals in early detection, education, and holistic management is emphasized as vital in addressing this dual disease burden. This review offers actionable insights into integrated strategies for addressing these interconnected conditions.
DO  - The Role of Type 3 Diabetes in Alzheimer’s Disease: A Review of Current Evidence
TI  - 10.31586/wjnr.2025.6068
ER  -