Back to Article
Cyclophosphamide Induces Hepatorenal Toxicity and Attenuation by 5-fluorouracil in Male Albino Rats
World Journal of Clinical Medicine Research
| Vol 2, Issue 1
Table 3. Serum urea, creatinine, and uric acid concentrations of rat treated with cyclophosphamide and/or 5-fluorouracil
| Groups Parameters | Control | CPA | 5-FU | CPA – 5-FU |
| Mean±SE | Mean±SE | Mean±SE | Mean±SE | |
| Serum urea concentration (g/dl) | 19.66±1.53 ab | 32.54±4.2 acd | 24.52±2.53 abd | 20.52±1.01 bc |
| Serum creatinine concentration (g/dl) | 0.65±0.03 b | 078±0.07 acd | 0.64±0.03 b | 0.62±0.07 b |
| Serum uric acid concentration (g/dl) | 2.34±0.25 ab | 1.08±0.17 acd | 1.43±0.17 abd | 1.50±0.09 bc |
Significance at P > 0.05. CPA: cyclophosphamide; 5-FU: Fluorouracil, a Comparison of control and other groups; b Comparison of CPA and other groups; c Comparison of 5-FU and other groups; d Comparison of CPA – 5-FU and other groups.