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Cyclophosphamide Induces Hepatorenal Toxicity and Attenuation by 5-fluorouracil in Male Albino Rats
World Journal of Clinical Medicine Research
| Vol 2, Issue 1
Table 2. Serum LDH, ALT,AST, and AL of rat treated with cyclophosphamide and/or 5-fluorouracil
| Groups Parameters | Control | CPA | 5-FU | CPA – 5-FU |
| Mean±SE | Mean±SE | Mean±SE | Mean±SE | |
| Serum LDH (IU/l) | 1109 ±164 bcd | 2086 ±187 ac | 1632 ±90abd | 2150 ±265 bc |
| Serum ALT (IU/l) | 24.4±11.4 bcd | 129.4±8.5 acd | 38.6±3.9ab | 42.4±9.4 ab |
| Serum AST (IU/l) | 116.6±6.2 bcd | 372.4±22 acd | 147±8.7 ab | 151.8±6.6 ab |
| Serum ALP (IU/l) | 128.8±9.02 bcd | 298.6±23.5 acd | 151±4.1 abd | 231.4±24.2 abc |
| Serum bilirubin (g/dl) | 0.228±0.013 bcd | 0.424±0.026 acd | 0.284±0.010 ab | 0.280±0.021 ab |
Significance at P > 0.05. CPA: cyclophosphamide; 5-FU: Fluorouracil, a Comparison of control and other groups; b Comparison of CPA and other groups; c Comparison of 5-FU and other groups; d Comparison of CPA – 5-FU and other groups.