Antibiotic treatment for infection with Shiga toxin producing Escherichia coli infection inducing a hemolytic uremic syndrome

Universal Journal of Pediatrics | Vol 1, Issue 1

Table 1. Course of events and laboratory variables.

Parameter	D1	D2	D3	D4	D5	D6	D7	D8	D9	D10	D11	D12	D13	D14	D15	D16	D17	D18
Shiga toxins	+/+				+/+			+/+				-/-			-/-			-/-
Antibiotics								M/A	M/A	M/A	M/A	M/A	M/A	M/A	M/A	M/A	M/A	M/A
PICU/W	PICU	PICU	PICU	W	W	W	W	PICU	PICU	PICU	PICU	PICU	PICU	PICU	W	W	W	W
P-CRP	38	45	78	72	70	50	65	52	47	79	40	16	9.5	6.9	9.2	3
B-WBC	29.6	24.1	22.5	23.5	22.6	20.1		37	26.1	29.1	32	24.8	15.8	9.1
B-Platelescount	76	83	105	101	93	49	20	15	56	107	237	347	470	373
B-Hemoglobin	115	91	121	84	81	80	113	74	102	104	95	95	99	88	92	96	92	89
B-Hematocrit	35	28	37	26	25	25	35	23	32	32	30	30	31	27	29	30	29	28
P-Na	124	126	134	139	139	137	135	137	137	138	134	134	136	135	136	136	138	138
S-LDH	52		50	38					18		11	10			6,5
P-K	3.7	3.5	4.1	4.4	4.1	4.3	5.4	4.1	3.7	4.3	5.2	4.4	5.0	4.9	4.3	4.7	4.2	4.1
Platelets								X
P-Creatinine	334	374	397	425	490	469	502	499	170	89	74	160	238	170	249	181
P-Urea	39.8	41.1	37.6	37.1	39.8	38.7	43.8	47.9	18.3	9	6.8	13.9	21.8	13.2	20.6	12.3
Diuresis	0	0	0	7	2	5	0	0	12	0	0	0	0	0	0	74	195	291
SAG		X				X		X							X
Ventilator								X	X	X	X

D – Day: starting D1 at admittance to the hospital, three days after onset of diarrhea; PICU – Pediatric intensive care unit; W – treatment at the hospital ward, P-CRP – C-reactive protein (mg/L; ref <3 mg/L); B-WBC – white blood count (x10^9/L); B-Hemoglobin (g/L; ref 100-150 g/L) ; B-Hematocrit (%; 37-41 %); P-Na (Sodium) (mmol/L; ref 137-145 mmol/L); P-K (potassium)( mmol/L ; ref 3.7-4.6 mmol/L; S-LDH- lactate dehydrogenase (µkat/L; ref 2.2 – 5.3 µkat/L) ; P-Creatinine (µmol/L; ref 17-42 µmol/L) ; P-Urea (mmol/l; ref 3.1 – 7.8 mmol/L), SAG - packed red cells diluted with saline-adenine-glucose-mannitol solution, (P – plasma, B - blood, S - serum).