The association between serum α1-AGP and chronic kidney disease among US female ages 20 to 49 years: Results from the 2015-2018 National Health and Nutrition Survey

Current Research in Public Health | Vol 5, Issue 1

Table 2. Univariate logistic regression analysis ofrisk factors associated with CKD.

Variables	OR (95%CI)	P	Variables	OR (95%CI)	P
Age, years	1.03 (1.01~1.05)	<0.001	BMI, kg/m²	0.97 (0.95~0.99)	0.002
Race, n (%)			SBP, mmHg	1.02 (1.01~1.03)	<0.001
Non-Hispanic White	1 (reference)		DBP, mmHg	1.03 (1.02~1.05)	<0.001
Non-Hispanic Black	1.25 (0.81~1.92)	0.315	WBC, *10⁹/L	0.98 (0.92~1.05)	0.632
Mexican American	1.47 (0.96~2.25)	0.078	HGB, g/dL	0.72 (0.65~0.80)	<0.001
Other Race	1.15 (0.77~1.7)	0.504	eGFR, mL/min/1.73m²	0.98 (0.98~0.99)	<0.001
Educational level, n (%)			ACR, mg/g	1.30 (1.25~1.36)	<0.001
High school or less	1 (reference)		Vitamin D, nmol/L	1.00 (1.00~1.01)	0.365
Some College	0.62 (0.37~1.04)	0.073	ALB, g/L	1.01 (0.97~1.05)	0.789
College or above	0.45 (0.28~0.74)	0.001	Uric acid, umol/L	0.99 (0.99~0.99)	<0.001
Marital status, n (%)			BUN, mmol/L	1.11 (1.02~1.22)	0.017
Married or living with partner	1 (reference)		Bicarbonate, mmol/L	1.02 (0.95~1.09)	0.547
Living alone	0.82 (0.60~1.12)	0.206	Calcium, mmol/L	0.60 (0.10~3.63)	0.575
Hypertension, n (%)	2.50 (1.78~3.50)	<0.001	Phosphorus, mmol/L	0.98 (0.40~2.41)	0.973
Diabetes, n (%)	2.64 (1.62~4.32)	<0.001	Cholesterol, mmol/L	1.44 (1.25~1.65)	<0.001
Physical activity, n (%)			HDL, mmol/L	1.26 (0.89~1.77)	0.197
Sedentary	1 (reference)		Triglycerides, mmol/L	0.76 (0.62~0.94)	0.009
Moderate	0.80 (0.56~1.15)	0.225	HbA1c, %	1.08 (0.92~1.26)	0.339
Vigorous	0.69 (0.45~1.06)	0.094	Folate, nmol/L	1.00 (1.00~1.00)	0.013
Smoking status, n (%)			hs-CRP, mg/L	1.01 (1.00~1.03)	0.129
Never	1 (reference)		Ferritin, ug/L	0.99 (0.99~1.00)	<0.001
Former	0.74 (0.44~1.22)	0.237	α1-AGP, g/L	0.50 (0.26~0.96)	0.038
Current	0.86 (0.57~1.29)	0.454

OR: Odds Ratio; CI: Confidence Interval; BMI, Body Mass Index; SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure; WBC, White Blood Cell count; HGB, Hemoglobin; eGFR, Estimated Glomerular Filtration Rate; ACR, Albumin-to-Creatinine Ratio; ALB, Albumin; BUN, Blood Urea Nitrogen; HDL, High-Density Lipoprotein; HbA1c, Hemoglobin A1c; hs-CRP, High-Sensitivity C-Reactive Protein; α1-AGP, Serum Alpha-1-Acid Glycoprotein.