The association between serum α1-AGP and chronic kidney disease among US female ages 20 to 49 years: Results from the 2015-2018 National Health and Nutrition Survey

Current Research in Public Health | Vol 5, Issue 1

Table 3. Association between serum α1-AGP and CKD in the multiple logistic regression model.

Variables	n.event%	Crude OR (95% CI)	Model 1 OR (95% CI)	Model 2 OR (95% CI)	Model 3 OR (95% CI)
CKD	188 (8.8)	0.50 (0.26~0.96) *	0.48 (0.25~0.94) *	0.39 (0.02~0.78) *	0.37 (0.16~0.84) *
α1-AGP Q1	54 (10.1)	1(Ref)	1(Ref)	1(Ref)	1(Ref)
α1-AGP Q2	53 (10.0)	0.99 (0.66~1.48)	0.97 (0.65~1.45)	0.97 (0.64~1.46)	1.08(0.7~1.67)
α1-AGP Q3	45 (8.4)	0.81 (0.54~1.23)	0.79 (0.52~1.20)	0.73 (0.47~1.12)	0.85(0.54~1.34)
α1-AGP Q4	36 (6.7)	0.64 (0.41~0.99) *	0.64 (0.41~0.99) *	0.58 (0.37~0.92) *	0.58(0.34~0.99) *
Trend test		0.031*	0.029*	0.009*	0.041*

Model 1: Age, Educational level; Model 2: Model 1+ BMI, SBP, DBP, Hypertension, Diabetes, physical activity; Model 3: Model 2+ Cholesterol, uric acid, hs-CRP, Ferritin, Vitamin D, HbA1c, Folate, HGB; *p < 0.05

OR, Odds Ratio; CI, Confidence Interval; CKD, Chronic Kidney Disease; α1-AGP, Serum Alpha-1-Acid Glycoprotein; Ref: Reference group (used to denote the group used as the baseline for comparison); Q1, Q2, Q3, Q4: Quartiles of Serum Alpha-1-Acid Glycoprotein (Q1 = lowest quartile, Q4 = highest quartile).