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Open Access December 22, 2025

Reimagining Mathematical Modeling for a Responsive and Integrated Future in Infectious Disease Epidemiology

Abstract Mathematical modeling plays a central role in infectious disease epidemiology, shaping outbreak response strategies and informing public health policy. The COVID-19 pandemic demonstrated the value of these models but also exposed persistent limitations related to data fragility, lack of transparency, limited stakeholder engagement, and insufficient consideration of social and political contexts. [...] Read more.
Mathematical modeling plays a central role in infectious disease epidemiology, shaping outbreak response strategies and informing public health policy. The COVID-19 pandemic demonstrated the value of these models but also exposed persistent limitations related to data fragility, lack of transparency, limited stakeholder engagement, and insufficient consideration of social and political contexts. Rather than critiquing modeling as a discipline, this perspective argues for a reorientation of infectious disease modeling toward a more responsive, equity-centered, and participatory paradigm. We propose a conceptual framework built on three interrelated principles: adaptability through real-time data integration, transparency via open-source and reproducible practices, and relevance through interdisciplinary and co-produced model design. Drawing on illustrative examples from COVID-19 and dengue control efforts, we highlight how integrating behavioral dynamics, local knowledge, and policy feedback can improve model usefulness and public trust. Reconceptualizing models as dynamic systems of inquiry rather than static forecasting tools can enhance decision-making and promote more equitable and effective responses to future public health emergencies.
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Open Access April 10, 2025

Advancements in Pharmaceutical IT: Transforming the Industry with ERP Systems

Abstract The pharmaceutical industry is undergoing a profound transformation driven by advancements in Information Technology (IT), with Enterprise Resource Planning (ERP) systems playing a pivotal role in reshaping operations. These systems offer integrated solutions that streamline key business processes, such as production, inventory management, supply chain optimization, regulatory compliance, and data [...] Read more.
The pharmaceutical industry is undergoing a profound transformation driven by advancements in Information Technology (IT), with Enterprise Resource Planning (ERP) systems playing a pivotal role in reshaping operations. These systems offer integrated solutions that streamline key business processes, such as production, inventory management, supply chain optimization, regulatory compliance, and data integration, contributing significantly to operational efficiency and organizational agility. This paper explores the evolution and impact of ERP systems within the pharmaceutical sector, highlighting their contributions to overcoming the industry’s inherent challenges, including complex regulatory requirements, the need for accurate and real-time data, and the demand for supply chain resilience. The integration of cloud-based ERP solutions, the incorporation of emerging technologies like Artificial Intelligence (AI), Machine Learning (ML), and the Internet of Things (IoT), and enhanced data analytics capabilities have revolutionized pharmaceutical IT. These advancements not only reduce operational costs, improve forecasting accuracy, and enhance collaboration but also ensure compliance with stringent global regulations, such as Good Manufacturing Practices (GMP) and FDA guidelines. Moreover, ERP systems have been instrumental in managing the pharmaceutical supply chain, ensuring product traceability, and improving inventory control and order fulfillment processes. This manuscript examines how ERP systems enable pharmaceutical companies to maintain high standards of product quality, improve decision-making, and ensure the safety and efficacy of drugs through robust tracking and auditing mechanisms. A case study of a pharmaceutical company that implemented an ERP system demonstrates the tangible benefits, including increased operational efficiency, improved compliance rates, and enhanced customer satisfaction. However, despite the clear advantages, challenges such as customization complexities, data integration issues, and resistance to change remain. As the pharmaceutical industry continues to evolve, ERP systems will remain a cornerstone of digital transformation, facilitating smarter decision-making, better resource management, and enhanced collaboration across global operations. This paper also identifies future trends, including the potential of AI and blockchain technologies in further strengthening ERP systems and transforming the pharmaceutical landscape.
Review Article
Open Access December 27, 2023

Leveraging Machine Learning Techniques for Predictive Analysis in Merger and Acquisition (M&A)

Abstract M&A is a strategic concept of business growth through consolidation, gaining market access, increasing strategic positions, and increasing operational efficiency. To understand the dynamics of M&A, this paper looks at aspects such as targeted firm identification, evaluation, bidding for the target firm, and post-acquisition integration. All forms of M&A, including horizontal, [...] Read more.
M&A is a strategic concept of business growth through consolidation, gaining market access, increasing strategic positions, and increasing operational efficiency. To understand the dynamics of M&A, this paper looks at aspects such as targeted firm identification, evaluation, bidding for the target firm, and post-acquisition integration. All forms of M&A, including horizontal, vertical, conglomerate, and acquisitions, are discussed in terms of goals and values, including synergy, cost reduction, competitive advantages, and access to better technology. However, issues such as cultural assimilation, adhesion to regulations, and calculating an inaccurate value are also resolved. The paper then goes deeper to provide insight into how predictive analytics applies to M&A, using ML to improve decision-making with forecasting benefits. Including healthcare, education, and construction industries, the presented predictive models using regression analysis, neural networks, and ensemble techniques help to make decisions. Through time series and real-time data, PDA enables sound M&A strategies, effective risk management and smooth integration.
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Open Access December 26, 2018

Understanding Consumer Behavior in Integrated Digital Ecosystems: A Data-Driven Approach

Abstract This study aims to achieve a new understanding of how, why, and when consumer behavior is shaped, enacted, and experienced inside and across integrated digital ecosystems related to large-scale trackable goods, all in service of helping marketers optimize their business performance in the new economy. The pioneering understanding begins by exploring what motivates the choices of a homogeneous [...] Read more.
This study aims to achieve a new understanding of how, why, and when consumer behavior is shaped, enacted, and experienced inside and across integrated digital ecosystems related to large-scale trackable goods, all in service of helping marketers optimize their business performance in the new economy. The pioneering understanding begins by exploring what motivates the choices of a homogeneous group of consumers to organize their consumption of national and store brand varieties of consumer package goods in a certain manner. Thereafter, the essay explores how, if at all, the other digital activities of consumers across various product-related digital spaces and on various platforms build expertise and interest in these products such that they exert an effect on the purchase choices for these products. The essay then advances to asking how online information seeking, in various product-related digital spaces, on various platforms, and from various sources, and taking place at various points in the purchase journey affects online-offline dynamics in purchasing these products. Thereafter, the research examines how paid digital communication in various product-related digital spheres and forms, enabled by consumer advertising engagement on various platforms, boosts the offline sales of these products. Finally, by employing a new methodology that combines consumer scanning data, self-reported online activity data, and transaction data collected from an ad-tech partner, the research presents a fresh set of marketing action levers and performance outcomes on chosen products. Along the way, progress is made on four under-investigated topics in the advertising literature – the role of consumer actors and their expertise in the online-offline purchasing dynamics for ads, advertising engagement, consumer digital spaces, and consumer digital activity investment.
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Open Access December 29, 2020

Enhancing Government Fiscal Impact Analysis with Integrated Big Data and Cloud-Based Analytics Platforms

Abstract While several application domains are exploiting the added-value of analytics over various datasets to obtain actionable insights and drive decision making, the public policy management domain has not yet taken advantage of the full potential of the aforementioned analytics and data models. To this end, in this paper authors present an overall architecture of a cloud-based environment that [...] Read more.
While several application domains are exploiting the added-value of analytics over various datasets to obtain actionable insights and drive decision making, the public policy management domain has not yet taken advantage of the full potential of the aforementioned analytics and data models. To this end, in this paper authors present an overall architecture of a cloud-based environment that facilitates data retrieval and analytics, as well as policy modelling, creation and optimization. The environment enables data collection from heterogeneous sources, linking and aggregation, complemented with data cleaning and interoperability techniques. An innovative approach for analytics as a service is introduced and linked with a policy development toolkit, which is an integrated web-based environment to fulfil the requirements of the public policy ecosystem stakeholders [1]. Large information databases on various public issues exist, but their usage for public policy formulation and impact analysis has been limited so far, as no cloud-based service ecosystem exists to facilitate their efficient exploitation. With the increasing availability and importance of both public big and traditional data, the need to extract, link and utilize such information efficiently has arisen. Current data-driven web technologies and models are not aligned with the needs of this domain, and therefore, potential candidates for big data, cloud-based and service-oriented public policy analysis solutions should be investigated, piloted and demonstrated [2]. This paper presents the conceptual architecture of such an ecosystem based on the capabilities of state-of-the-art cloud and web technologies, as well as the requirements of its users.
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Review Article
Open Access December 26, 2020

Automated Vulnerability Detection and Remediation Framework for Enterprise Databases

Abstract Enterprise databases are the heart of applications and contain the most sensitive and critical information of organizations. While there have been significant advances in the security of databases, vulnerabilities still exist due to mistakes made by application developers, database administrators, and users. Manual detection and patching of such vulnerabilities typically take months, but an [...] Read more.
Enterprise databases are the heart of applications and contain the most sensitive and critical information of organizations. While there have been significant advances in the security of databases, vulnerabilities still exist due to mistakes made by application developers, database administrators, and users. Manual detection and patching of such vulnerabilities typically take months, but an automated detection and remediation framework is proposed to fill the gap and eliminate a significant number of these vulnerabilities in near-real time. This framework comprises two key components: a detection engine that leverages static analysis to identify potential patches, coupled with query dynamic testing and fuzzing to identify exploitable misconfigurations; and an orchestration engine that applies detected patches on the database, validates the accuracy of the fix, and rolls back changes if the problem is not resolved. A prototype of this framework has been implemented and validated on a real-time database deployed in an enterprise environment. Because of the complexity of the problem landscape, the research focus is on static vulnerability detection and automated corrective actions. These two capabilities can greatly reduce the manual workload associated with vulnerability detection and significantly enhance the assurance that the granted privileges validate the least privilege principle. The proposed architecture aims to enable the deployment of a detection-and-remediation solution that minimizes human effort, reduces the enterprise-at-risk window, and maximizes the volume of detected vulnerabilities.
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Review Article
Open Access December 26, 2021

Scalable Data Warehouse Architecture for Population Health Management and Predictive Analytics

Abstract Scalable architecture principles for data warehousing are introduced to support population health management and predictive analytics. These principles are validated through the design of an accompanying Data Pipeline that allows the integration of non-traditional data sources, the use of real-time data for descriptive analytics dashboards, and support for the generation of supervised Machine [...] Read more.
Scalable architecture principles for data warehousing are introduced to support population health management and predictive analytics. These principles are validated through the design of an accompanying Data Pipeline that allows the integration of non-traditional data sources, the use of real-time data for descriptive analytics dashboards, and support for the generation of supervised Machine Learning models. Several analytical capabilities have been implemented to exemplify the practical application of the principles, including predictive models for Risk Stratification in health care. Optimal cost-effectiveness and performance considerations ensure the practical relevance of the architectural principles and associated Data Pipeline. In recent years, the availability of Low-Cost Data Storage services and the increasing popularity of Streaming technologies opened new possibilities for the storage and processing of Streaming data on a near-real-time basis. These technologies can help Developing Countries in tackling many relevant issues such as Urban Planning, Environmental Management, Migration Policies, etc. A multi-tier approach combining Cloud-based Storage with Data Warehousing and Data Mining technologies can offer an interesting architecture to exploit Big Data related to populations.
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Review Article
Open Access December 26, 2021

Designing Scalable Healthcare Data Pipelines for Multi-Hospital Networks

Abstract Healthcare is increasingly recognized as a data-intensive industry. Multi-hospital networks, among other organizations, face mounting operational and governance challenges because of rigid data-integration pipelines that support all data sources and destinations in the network. These pipelines have become difficult to modify, causing them to lag behind the changing needs of the clinical operation. [...] Read more.
Healthcare is increasingly recognized as a data-intensive industry. Multi-hospital networks, among other organizations, face mounting operational and governance challenges because of rigid data-integration pipelines that support all data sources and destinations in the network. These pipelines have become difficult to modify, causing them to lag behind the changing needs of the clinical operation. Scalable data-pipeline architectures better support clinical decision making, optimize hospital operations, ease data quality and compliance concerns, and contribute to improved patient outcomes. Meeting scalability goals requires breaking up monolithic data-integration pipelines into smaller decoupled components and aligning service-level agreements of pipeline components and source systems. Parallelization and adoption of distributed data-warehouse technology mitigate the burden of ingesting data into a multi-hospital network. However, latency requirements still warrant the construction of separate pipelines for data ingress from clinical devices, electronic health records, and external laboratory-information systems. Healthcare associations recommend near real-time data availability for a growing list of clinical and operational applications. Mishandling the real-time ingestion of data from clinical devices, in particular, compromises availability and performance. Scalable architectural patterns for real-time streaming Ingestion from heterogeneous data sources, transport processes, and back-end processing structures are detailed.
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Keyword:  Real-Time Data

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