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Open Access June 26, 2025

Mathematical modelling of the impact of HIV prevention strategies among female sex workers on public health in Burkina Faso

Abstract This article presents a mathematical model designed to simulate the impact of targeted interventions aimed at preventing HIV transmission among female sex workers (FSWs) and their clients, while also analyzing their effects on the health of the general population. The compartmental model distinguishes between high-risk populations (FSWs and their clients) and low-risk populations (sexually active [...] Read more.
This article presents a mathematical model designed to simulate the impact of targeted interventions aimed at preventing HIV transmission among female sex workers (FSWs) and their clients, while also analyzing their effects on the health of the general population. The compartmental model distinguishes between high-risk populations (FSWs and their clients) and low-risk populations (sexually active men and women in the general population), and links prevention efforts in high-risk groups to the evolution of the epidemic in the low-risk population. The fundamental properties of the model, such as the positivity of solutions and the boundedness of the system, have been verified, and the basic reproduction number R0 has been calculated. Finally, the stability of the model was studied using Varga’s theorem and the Lyapunov method. Simulation results show that targeted prevention among FSWs and their clients reduces HIV incidence in the general population. This framework provides a valuable tool for guiding policymakers in the design of effective strategies to combat the epidemic, especially relevant in the context of suspension of USAID funding.
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Open Access November 01, 2023

Individual Wave Component Signal Modeling, Parameters Extraction, and Analysis

Abstract The accurate estimation of Individual Wave Components (IWC) is crucial for automated diagnosis of the human digestive system in a clinical setting. However, this process can be challenging due to signal contamination by other signal sources in the body, such as the lungs and heart, as well as environmental noise. To address this issue, various denoising techniques are commonly employed in bowel [...] Read more.
The accurate estimation of Individual Wave Components (IWC) is crucial for automated diagnosis of the human digestive system in a clinical setting. However, this process can be challenging due to signal contamination by other signal sources in the body, such as the lungs and heart, as well as environmental noise. To address this issue, various denoising techniques are commonly employed in bowel sound signal processing. While denoising is important, it can increase computational complexity, making it challenging for portable devices. Therefore, signal processing algorithms often require a trade-off between fidelity and computational complexity. This study aims to evaluate an IWC parameter extraction algorithm that was previously developed and reconstruct the IWC without denoising using synthetic and clinical data. To that end, the role of a reliable model in creating synthetic data is paramount. The rigorous testing of the algorithm is limited by the availability of quality and quantity recorded data. To overcome this challenge, a mathematical model has been proposed to generate synthetic bowel sound data that can be used to test new algorithms. The proposed algorithm’s robust performance is evaluated using both synthetic and clinically recorded data. We perform time-frequency analysis of original and reconstructed bowel sound signals in various digestive system states and characterize the performance using Monte Carlo simulation when denoising is not applied. Overall, our study presents a promising algorithm for accurate IWC estimation that can be useful for predicting anomalies in the digestive system.
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Open Access March 30, 2023

Pulsatile Blood Flow Simulation for Subject-Specific Geometry of a Human Aortic Arch

Abstract Pulsatile blood flow in a subject-specific human aortic arch and its major branches is studied computationally for a peak Reynolds number of 1553 and a Womersley number of 22.74. The aortic geometry is constructed from the CT-scan images of a subject. The aorta has out-of-plane curvature and significant area variation along the flow direction. A physiologically representative pulsatile velocity [...] Read more.
Pulsatile blood flow in a subject-specific human aortic arch and its major branches is studied computationally for a peak Reynolds number of 1553 and a Womersley number of 22.74. The aortic geometry is constructed from the CT-scan images of a subject. The aorta has out-of-plane curvature and significant area variation along the flow direction. A physiologically representative pulsatile velocity waveform is applied as boundary condition at the inlet of the aorta. The primary velocity profiles are skewed towards the inner wall of the ascending aorta during the entire cardiac cycle. In the decelerating phase, reverse flow is noted along the inner wall and the magnitude of maximum velocity is about 50 % of the peak flow condition. Flow separation is observed in the inner wall of the ascending aorta during the decelerating and reverse flow phases of the cardiac cycle. In the accelerating phase, however, flow separation does not occur. The major observation of the present work is the existence of complex and asymmetrical vortical flow structures which are not observed either in simple curved pipes or in idealized aortic arch computational studies. The relative strength of the secondary flow with respect to the primary flow is quantified by means of Relative Secondary Kinetic Energy whose highest value is evaluated to be 1.202 occurring near the entrance of the right carotid artery during the maximum reverse flow condition. High values of wall shear stress is observed at distal of the left and right subclavian arteries, the bifurcation of brachiocephalic artery between right subclavian artery and right carotid artery, and proximal inner wall of descending aorta during the cardiac cycle. The wall shear stress at the bifurcations of the branches are low and oscillatory and generally correlates with the preferential sites for atherosclerosis. The flow structures on the aorta wall are explicitly highlighted by the limiting streamlines. The application of limiting streamlines to clearly elucidate the complex on-wall flow structures is one of the key contributions of the present study. During the decelerating and reverse flow phases several critical points are observed on the aortic wall. These complex flow structures vanish during the accelerating phase. The observations made in the present study will be helpful in creating accurate and clinically useful computational models.
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Open Access October 29, 2022

Measurement of conversion factor into mean glandular dose in mammography using OSL dosimeters

Abstract Background: Currently, the DRL quantity in mammography are evaluated in terms of mean glandular dose (MGD). Since the MGD cannot be measured directly, it can be obtained by calculation using the equation (D=K*g*c*s). In previous studies, the conversion factor g was calculated by Monte Carlo simulation and is not reported from actual measurements. In this study, we focused on the [...] Read more.
Background: Currently, the DRL quantity in mammography are evaluated in terms of mean glandular dose (MGD). Since the MGD cannot be measured directly, it can be obtained by calculation using the equation (D=K*g*c*s). In previous studies, the conversion factor g was calculated by Monte Carlo simulation and is not reported from actual measurements. In this study, we focused on the g-factor, which is a conversion factor to the MGD at 50% glandularity, and attempted to measure it using a nanoDot dosimeter to see if it can be used in mammography. Methods: The nanoDot dosimeters were inserted in a PMMA phantom at depths ranging from 0 cm to 6 cm in 1 cm increments, and measurements were made in three HVLs of 0.3 mmAl, 0.35 mmAl, and 0.4 mmAl HVL. The g-factor was calculated from the nanoDot dosimeter values using a conversion equation. Results and Discussion: The measured g-factors for all the HVLs were in close agreement with those of Dance et al. The values of the previous studies did not include the backscatter factor, which may have underestimated the MGD. The difference was smaller for the 0.4 mm Al. Compared to the other HVLs, the 0.4 mm Al was measured without a compression plate, which may have been influenced by the presence or absence of a compression plate. Conclusion: The nanoDot dosimeters were used to calculate g-factors. The results agreed with those of previous studies within uncertainty. This indicates that nanoDot dosimeters can be used in the mammography field.
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Open Access November 09, 2025

Application of Building Information Modelling (BIM) for Enhancing Safety and Environmental Performance on Construction Sites in Nigeria

Abstract Background: Building Information Modelling (BIM) improves safety planning in construction by enabling visualization and simulation to identify and reduce risks. However, its adoption in Nigeria is limited. This study examines the application of BIM in enhancing safety and environmental performance on construction sites in Nigeria. Methodology: A quantitative cross-sectional survey [...] Read more.
Background: Building Information Modelling (BIM) improves safety planning in construction by enabling visualization and simulation to identify and reduce risks. However, its adoption in Nigeria is limited. This study examines the application of BIM in enhancing safety and environmental performance on construction sites in Nigeria. Methodology: A quantitative cross-sectional survey was conducted using a structured online questionnaire distributed to professionals in Nigeria’s construction industry. A purposive sampling method was employed to target respondents with relevant BIM experience. Data were analysed using SPSS version 28, applying descriptive statistics, chi-square tests, and logistic regression at a 5% significance level. Result: Findings show that BIM was fully adopted by 7.0% of organizations, with only 19.8% of respondents using it to identify safety hazards during planning. While 76.8% reported no notable safety benefit, 19.5% identified improved risk management as the key benefit. Most respondents (80.2%) reported no noticeable environmental benefits. Among those who did, improved energy efficiency was the most cited benefit (16.4%). Respondents with 10 or more years of experience were significantly more likely to report enhanced safety and environmental outcomes (AOR = 4.555; p = 0.003) and adequate BIM utilization (AOR = 3.255; p = 0.023). Those with intermediate BIM experience were also more likely to report high enhancement (AOR = 2.857; p = 0.039) and effective tool use (AOR = 2.881; p = 0.050). Conclusion: This study revealed that BIM has the potential to improve construction outcomes in Nigeria if supported by training, experience, and structured implementation.
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Open Access October 09, 2025

Simulation-Based Learning in Nursing Education: Perspectives of Student Nurses in the Philippines

Abstract Simulation-based learning (SBL) is widely recognized as an effective educational approach that bridges theory and practice in nursing education. Despite its global adoption, limited research has examined the experiences of Filipino nursing students with SBL, particularly in resource-constrained settings. This study explored the perspectives of Bachelor of Science in Nursing students from a [...] Read more.
Simulation-based learning (SBL) is widely recognized as an effective educational approach that bridges theory and practice in nursing education. Despite its global adoption, limited research has examined the experiences of Filipino nursing students with SBL, particularly in resource-constrained settings. This study explored the perspectives of Bachelor of Science in Nursing students from a university in Metro Manila, Philippines, on the impact of SBL on their skills, emotional responses, and challenges encountered. A descriptive qualitative design was employed using purposive sampling of ten students who had participated in at least one SBL activity. Data were collected through semi-structured interviews and short written reflections and analyzed thematically following Braun and Clarke’s framework to capture nuanced experiences. Three major themes emerged from the analysis. First, students reported initial anxiety, nervousness, and stress during their early SBL experiences, which gradually transformed into confidence, adaptability, and resilience as they gained familiarity and competence. Second, SBL enhanced technical and cognitive skills such as clinical judgment, decision-making, teamwork, and patient-centered care, supporting students’ readiness for real-world practice. Third, students identified resource limitations, insufficient equipment, and time constraints as significant barriers to optimal learning, though these challenges also fostered creativity and perseverance. The findings demonstrate that SBL fosters technical competence, critical thinking, and professional growth but requires institutional support to address resource constraints and faculty development needs. This study underscores the importance of expanding SBL in Philippine nursing curricula to align with international best practices and to contribute to Sustainable Development Goals 3 (good health and well-being), 4 (quality education), and 5 (gender equality).
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Open Access September 28, 2025

Gut-Brain Axis in Autism Spectrum Disorder: A Bibliometric and Microbial-Metabolite-Neural Pathway Analysis

Abstract The gut-brain axis (GBA) has emerged as a central focus in the study of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). Research suggests that microbial composition and its metabolic byproducts influence neural development, synaptic plasticity, and behavior [1,2,3]. A structured bibliometric analysis of Scopus and Web of Science records was performed using Bibliometrix [...] Read more.
The gut-brain axis (GBA) has emerged as a central focus in the study of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). Research suggests that microbial composition and its metabolic byproducts influence neural development, synaptic plasticity, and behavior [1,2,3]. A structured bibliometric analysis of Scopus and Web of Science records was performed using Bibliometrix and VOSviewer to trace trends and thematic evolution of GBA–ASD literature [7,8]. In parallel, a data-driven pathway modeling approach maps microbial metabolites (e.g., short-chain fatty acids, tryptophan catabolites) to host signaling pathways including vagal stimulation, immune cytokine modulation, and blood–brain barrier (BBB) permeability [4,5]. Simulations implemented in Python’s NetworkX illustrate how perturbations in metabolite flux may influence CNS outcomes. The findings reveal growing emphasis on butyrate, serotonin, microglial priming, and maternal immune activation in ASD-related GBA studies, and highlight the need for rigorous empirical validation of computational predictions [9,10,11].
Brief Report
Open Access January 21, 2025

A Disaster Management Contingency and Training Plan for Nursing Service Personnel

Abstract Background: Disasters such as typhoons, floods, and earthquakes frequently impact the Philippines, placing nurses at the forefront of response and care. Given these recurring threats, ensuring that nurses possess adequate awareness, knowledge, and skills is crucial to mitigate risks, enhance preparedness, and promote effective disaster management. Aim/Objectives: This study sought to [...] Read more.
Background: Disasters such as typhoons, floods, and earthquakes frequently impact the Philippines, placing nurses at the forefront of response and care. Given these recurring threats, ensuring that nurses possess adequate awareness, knowledge, and skills is crucial to mitigate risks, enhance preparedness, and promote effective disaster management. Aim/Objectives: This study sought to (1) assess the current levels of awareness, knowledge, skills, and involvement of private hospital nurses in Rizal Province across four phases of disaster management—mitigation and prevention, preparedness, response, and rehabilitation and recovery; and (2) propose a contingency and training plan based on identified gaps. Methods: A descriptive correlational design was employed. A total of 350 nurses from Level 1, 2, and 3 hospitals participated by completing a validated questionnaire. Data were analyzed using descriptive statistics, analysis of variance, and correlation tests to identify differences and relationships among variables. Results: Overall, the nurses reported very high levels of awareness and skills, coupled with a high level of knowledge and significant involvement in disaster-related activities. Nurses in larger (Level 3) hospitals exhibited higher practical readiness and engagement, while those in Level 1 and 2 facilities had comparatively lower scores. Positive correlations emerged between higher levels of awareness, knowledge, and skills and increased engagement in disaster initiatives. Conclusion: Building on these findings, a targeted contingency and training plan was designed using Pucel’s Performance-based Instructional Design, emphasizing hands-on simulations, structured policy briefings, and collaborative efforts with local disaster risk reduction offices. Addressing these specific gaps can bolster hospital preparedness, strengthen community resilience, and ensure more effective disaster response and patient care.
Article
Open Access July 16, 2024

Management of Saltwater Intrusion in Coastal Aquifers: A Review and Case Studies from Egypt

Abstract Groundwater is undeniably crucial to people's lives, particularly in coastal regions. Therefore, it is imperative to address this vital water source strategically and implement a management plan to maintain its optimal state. The salinization of groundwater poses a significant challenge for coastal communities, stemming from factors like excessive groundwater extraction from coastal aquifers, [...] Read more.
Groundwater is undeniably crucial to people's lives, particularly in coastal regions. Therefore, it is imperative to address this vital water source strategically and implement a management plan to maintain its optimal state. The salinization of groundwater poses a significant challenge for coastal communities, stemming from factors like excessive groundwater extraction from coastal aquifers, reduced recharge, rising sea levels, climate change, and other causes. Saltwater intrusion (SWI) is a prevalent issue that needs attention, as it significantly threatens groundwater quantity and quality. SWI happens when saline water infiltrates coastal aquifers, contaminating freshwater supplies. This review article aims to define SWI, explore its causes and influencing factors, and discuss various monitoring techniques. Additionally, it examines different modeling methods and management tools, including remote sensing, field surveys, modeling approaches, and optimization techniques. To mitigate the adverse effects of SWI, several control measures are outlined, along with their pros and cons. The final section reviews previous SWI studies and case studies from the Nile Delta, Sinai Peninsula, and North-West coast in Egypt. These studies offer suggestions, adaptations, and mitigation measures for future research.
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Open Access March 06, 2024

Embedded Architecture of SAP S/4 HANA ERP Application

Abstract The SAP HANA Application to handle operational workloads that are consistent with transactions while also supporting intricate business analytics operations. Technically speaking, the SAP HANA database is made up of several data processing engines that work together with a distributed query processing environment to provide the entire range of data processing capabilities. This includes graph and [...] Read more.
The SAP HANA Application to handle operational workloads that are consistent with transactions while also supporting intricate business analytics operations. Technically speaking, the SAP HANA database is made up of several data processing engines that work together with a distributed query processing environment to provide the entire range of data processing capabilities. This includes graph and text processing for managing semi-structured and unstructured data within the same system, as well as classical relational data that supports both row- and column-oriented physical representations in a hybrid engine. The next-generation SAP Business Suite program designed specifically for the SAP HANA Platform is called SAP S/4HANA. The key features of SAP S/4HANA are an intuitive, contemporary user interface (SAP Fiori); planning and simulation options in many conventional transactions; simplification of business processes; significantly improved transaction efficiency; faster analytics.
Review Article
Open Access July 28, 2023

Some Software Application of the Monte Carlo Method

Abstract We study the using the Monte Carlo method and its application. Below are several examples of software implementations of the Monte Carlo method for performing calculations that will allow us to determine the necessary information in cases where probability can be applied. Below is a software implementation of the examples in the C# programming language. The programs have a desktop interface and [...] Read more.
We study the using the Monte Carlo method and its application. Below are several examples of software implementations of the Monte Carlo method for performing calculations that will allow us to determine the necessary information in cases where probability can be applied. Below is a software implementation of the examples in the C# programming language. The programs have a desktop interface and allow us to calculate such values as the number π and the time required to perform certain actions.
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Open Access November 04, 2022

An Artificial Intelligence Approach to Manage Crop Water Requirements in South Africa

Abstract Estimation of crop water requirements is of paramount importance towards the management of agricultural water resources, which is a major mitigating strategy against the effects of climate change on food security. South Africa water shortage poses a threat on agricultural efficiency. Since irrigation uses about 60% of the fresh water available, it therefore becomes important to optimise the use of [...] Read more.
Estimation of crop water requirements is of paramount importance towards the management of agricultural water resources, which is a major mitigating strategy against the effects of climate change on food security. South Africa water shortage poses a threat on agricultural efficiency. Since irrigation uses about 60% of the fresh water available, it therefore becomes important to optimise the use of irrigation water in order to maximize crop yield at the farm level in order to avoid wastage. In this study, combined application of an artificial neural network (ANN) and a crop – growth simulation model for the estimation of crop irrigation water requirements and the irrigation scheduling of potatoes at Winterton irrigation scheme, South Africa was investigated. The crop-water demand from planting to harvest date, when to irrigate, the optimum stage in the drying cycle when to apply water and the amount of irrigation water to be applied per time, were estimated in this study. Five feed –forward backward propagation artificial neural network predictive models were developed with varied number of neurons and hidden layers and evaluated. The optimal ANN model, which has 5 inputs, 5 neurons, 1 hidden layer and 1 output was used to predict monthly reference evapotranspiration (ETo) in the Winterton area. The optimal ANN model produced a root-mean-square error (RMSE) of 0.67, Pearson correlation coefficient (r) of 0.97 and coefficient of determination (R2) of 0.94. The validation of the model between the measured and predicted ETo shows a r value of 0.9048. The predicted ETo was one of the input variables into a crop growth simulation model, called CROPWAT. The results indicated that the total crop water requirement was 1259.2 mm/decade and net irrigation water requirement was 1276.9 mm/decade, spread over a 5-day irrigation time during the entire 140 days of cropping season for potatoes. A combination of the artificial neural networks and the crop growth simulation models have proved to be a robust technique for estimating crop irrigation water requirements in the face of limited or no daily meteorological datasets.
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Open Access August 24, 2022

Performance Analysis of an Ultra-Wide Band (UWB) Antenna for Communication System

Abstract A spherical shape ultra-wideband antenna is a microstrip patch antenna whose emitted signal bandwidth exceeds the lesser of 500 MHz. One of the major issues hindering the ultra-wideband antennas is poor diversity factors, poor voltage standing wave ratio and poor power efficiency to transmit the required signals. In this research work, the method of approach is the design and analysis of a [...] Read more.
A spherical shape ultra-wideband antenna is a microstrip patch antenna whose emitted signal bandwidth exceeds the lesser of 500 MHz. One of the major issues hindering the ultra-wideband antennas is poor diversity factors, poor voltage standing wave ratio and poor power efficiency to transmit the required signals. In this research work, the method of approach is the design and analysis of a spherical shape ultra-wideband antenna with the use of computer simulation technology (CST). This antenna is working under the resonant frequency of 6 GHz on a frequency bandwidth of 4-9 GHz. However, this research work has made an intensive review of related works. A spherical shape microstrip antenna with a diameter of 13mm and a radius of 6.5mm was designed, after which a simulation was carried out using the computer simulation technology software. The result from the radiated power shows how high the radiative efficiency is and from the results we were able to observe that the ultra-wideband antenna uses a very low amount of power but can transmit a better outgoing power from the 0.5 watts stimulated power. In this research work, an evaluation process on the envelope correlation coefficient of the antenna s-parameters was carried out, with a good result was obtained. Most importantly the diversity gain of the antenna proves to be good and efficient due to the effectiveness of the antenna radiation efficiency. The results of this antenna produce a very good voltage standing wave ratio (VSWR), the voltage standing wave ratio of this spherical ultra-wideband antenna is less than 2% with a very low return loss reflection. In conclusion, the spherical shape antenna is good for ultra-wideband purposes because of its robustness in delivering high-quality signals with a very low return loss. So, it stands the chance of recommendations in the communication industries due to its high radiation efficiency rate and good VSWR.
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Open Access July 25, 2022

Techniques and Strategies Use in Assessing Social Studies Concepts

Abstract The purpose of the study was to examine techniques and strategies use in assessing Social Studies concepts in the three senior high schools in Sefwi Wiawso Municipality in the Western North Region of Ghana. Qualitatively, the research design for this study was a Case study. The population for this study consisted of all ten (10) Social Studies teachers in three public Senior High Schools (Wiawso [...] Read more.
The purpose of the study was to examine techniques and strategies use in assessing Social Studies concepts in the three senior high schools in Sefwi Wiawso Municipality in the Western North Region of Ghana. Qualitatively, the research design for this study was a Case study. The population for this study consisted of all ten (10) Social Studies teachers in three public Senior High Schools (Wiawso Senior High School, Wiawso Senior/Technical school, and Asawinso senior high school) in Sefwi Wiawso municipality in the Western North Region of Ghana. Purposive and convenient sampling techniques were used to select municipalities, schools, and Social Studies teachers for the study. The main instrument used for data collection was interview. The data were edited before being analyzed in themes and pattern. Being a case study design in qualitative research, the researcher read through the data several times so as to familiarize with the data, making notes, referring back to the research question, making decisions whether to focus on individual responses or on topics. The interview data were interpreted to articulate meaning, making decisions on whether to use direct quotes or the summary of respondents’ responses and reporting the data considering the interest of various audiences. The study revealed that teachers used various teaching techniques such as brainstorming, simulation, discovery-learning, role-play discussion, dramatization, problem-solving, and building a community implies that they believed in child-centered method of the teaching and learning of Social Studies. The study also concluded that Social Studies teachers use techniques and strategies like concept attainment, field trips, and debate co-operative learning in motivating and providing learners with the opportunity to interact with their own community or environment. It is recommended that Social Studies teachers should make effort either to go on field trips or make use of available experts that are in their communities by inviting them into the Social Studies classrooms to tap into their rich knowledge to enhance concept learning. It is also recommended that frequent seminars and periodic or regular in-service training should be organised by the Ghana Education Service to help Social Studies teachers to acquaint themselves with the modern teaching techniques and strategies that promote the teaching and learning of Social Studies concepts.
Article
Open Access April 22, 2022

Particle Swarm Network Design for UCAV Intelligence System Path Planning

Abstract In military battle, the unmanned combat aerial vehicle (UCAV) plays a critical role. The UCAV avoids the fatal military zone as well as radars. If there is just a narrow path between the defensive areas, it is dan-gerous. It chooses the quickest and safest path. The balance evolution technique is used to improve the path planning of UCAV in this study, which results in a novel artificial bee [...] Read more.
In military battle, the unmanned combat aerial vehicle (UCAV) plays a critical role. The UCAV avoids the fatal military zone as well as radars. If there is just a narrow path between the defensive areas, it is dan-gerous. It chooses the quickest and safest path. The balance evolution technique is used to improve the path planning of UCAV in this study, which results in a novel artificial bee colony. To regulate the position of a swarm of UCAVs, a particle swarm network is used to communicate between the UCAVs in the swarm. According to simulation data, the particle swarm network technique is more efficient than the ABC ap-proach. The intelligence system is taught via an artificial neural network.
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Open Access February 24, 2022

Computational Fluid Dynamics Modeling of Thermally Integrated Microchannel Reforming Reactors for Hydrogen Production

Abstract Many attempts have been made to improve heat transfer for thermally integrated microchannel reforming reactors. However, the mechanisms for the effects of design factors on heat transfer characteristics are still not fully understood. This study relates to a thermochemical process for producing hydrogen by the catalytic endothermic reaction of methanol with steam in a thermally integrated [...] Read more.
Many attempts have been made to improve heat transfer for thermally integrated microchannel reforming reactors. However, the mechanisms for the effects of design factors on heat transfer characteristics are still not fully understood. This study relates to a thermochemical process for producing hydrogen by the catalytic endothermic reaction of methanol with steam in a thermally integrated microchannel reforming reactor. Computational fluid dynamics simulations are conducted to better understand the consumption, generation, and exchange of thermal energy between endothermic and exothermic processes in the reactor. The effects of wall heat conduction properties and channel dimensions on heat transfer characteristics and reactor performance are investigated. Thermodynamic analysis is performed based on specific enthalpy to better understand the evolution of thermal energy in the reactor. The results indicate that the thermal conductivity of the channel walls is fundamentally important. Materials with high thermal conductivity are preferred for the channel walls. Thermally conductive ceramics and metals are well-suited. Wall materials with poor heat conduction properties degrade the reactor performance. Reaction heat flux profiles are considerably affected by channel dimensions. The peak reaction heat flux increases with the channel dimensions while maintaining the flow rates. The change in specific enthalpy is positive for the exothermic reaction and negative for the endothermic reaction. The change in specific sensible enthalpy is always positive. Design recommendations are made to improve thermal performance for the reactor.
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Open Access September 04, 2021

Active Fault Tolerant Control of Faulty Uncertain Neutral Time-Delay Systems

Abstract The present paper attempts to investigate the problem of Fault Tolerant Control for a class of uncertain neutral time delay systems. In the first time, we consider an additive control that is based on adding a term to the nominal law when the fault occurs. This approach will be designed in three steps. The first step is fault detection while the second one is fault estimation. For these two steps, [...] Read more.
The present paper attempts to investigate the problem of Fault Tolerant Control for a class of uncertain neutral time delay systems. In the first time, we consider an additive control that is based on adding a term to the nominal law when the fault occurs. This approach will be designed in three steps. The first step is fault detection while the second one is fault estimation. For these two steps, we consider the adaptive observer to guarantee the detection and estimation of the fault. The third step is the fault compensation. Lyapunov method and Linear Matrix Inequality (LMI) techniques were considered to improve the main method. Second, we propose a Pseudo Inverse Method "PIM" and determine the error between the closed loop and the nominal system. Finally, simulation results are presented to prove the theoretical development for an example of an uncertain neutral time delay system.
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Open Access August 21, 2021

Virologic Microparticle Fluid Mechanics Simulation: COVID-19 Transmission in the Protected and Unprotected Conversations

Abstract SARS-COV-19 is a serious respiratory infection created by a devastating coronavirus family (2019-nCoV) that has become the first global epidemic of the last one hundred years. It is a highly transmissible virus transmitted by inhalation or contact with the droplet core produced by infected people when they sneeze, cough, and speak. SARS-COV-2 transmission in the air is possible even in a confined [...] Read more.
SARS-COV-19 is a serious respiratory infection created by a devastating coronavirus family (2019-nCoV) that has become the first global epidemic of the last one hundred years. It is a highly transmissible virus transmitted by inhalation or contact with the droplet core produced by infected people when they sneeze, cough, and speak. SARS-COV-2 transmission in the air is possible even in a confined space near the infected person. This study aimed to evaluate the effectiveness of using a shield or mask as a barrier to a patient’s face against the spread of virus particles. For the present simulation, the discrete phase model (DPM) is used; Because this model allows us to study the particle’s mass discretely in a fluid space with the continuous phase. Due to the choice of this model, the virus particles secreted from the patient’s mouth are considered a discrete phase, and the open airflow in the computational area is considered a continuous phase. The present study uses fluent 2019R3 software to simulate the virus transmission to model the transient flows numerically. The analysis found that the masks or shields can be an effective method of protecting the participants of a conversation in the presence of an infected person.
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Review Article
Open Access December 27, 2022

Advancing Pain Medicine with AI and Neural Networks: Predictive Analytics and Personalized Treatment Plans for Chronic and Acute Pain Managements

Abstract There is a growing body of evidence that the number of individuals suffering from chronic and acute pain is under-reported and the burden of the veteran, aging, athletic, and working populations is rising. Current pain management is limited by our capacity to collaborate with individuals continuing normal daily functions and self-administration of pain treatments outside of traditional healthcare [...] Read more.
There is a growing body of evidence that the number of individuals suffering from chronic and acute pain is under-reported and the burden of the veteran, aging, athletic, and working populations is rising. Current pain management is limited by our capacity to collaborate with individuals continuing normal daily functions and self-administration of pain treatments outside of traditional healthcare appointments and hospital settings. In this review, the current gap in clinical care for real-time feedback and guidance with pain management decision-making for chronic and post-operative pain treatment is defined. We examine the recent and future applications for predictive analytics of opioid use after surgery and implementing real-time neural networks for personalized pain management goal setting for particular individuals on the path to discharge to normal function. Integration of personalized neural networks with longitudinal data may enable the development of future treatment personalizations paired with electrical simulations.
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Review Article
Open Access December 27, 2019

Predictive Analytics in Biologics: Improving Production Outcomes Using Big Data

Abstract Biopharmaceuticals, or biologics, are a burgeoning sector in the pharmaceutical industry, predicted to reach $239.4 billion by 2025. This unparalleled growth is often attributed to the enhanced specificity offered by large molecules over small molecules. The large size of the constituent proteins necessitates the continuous implementation of big data predictive analytics to elucidate the most [...] Read more.
Biopharmaceuticals, or biologics, are a burgeoning sector in the pharmaceutical industry, predicted to reach $239.4 billion by 2025. This unparalleled growth is often attributed to the enhanced specificity offered by large molecules over small molecules. The large size of the constituent proteins necessitates the continuous implementation of big data predictive analytics to elucidate the most effective candidates in the lead optimization process. These same methodologies can be applied, and with the advent of machine learning and automated predictive analytics, this is becoming an increasingly facile task, to the augmentation and optimization of the downstream production processes that comprise the majority of the development cost of any biologic. In this work, big data from cell line generation, product and process design, and large-scale lead validation studies have been used to compare the applicability of simple statistical models against these black-box approaches for the rapid acceleration of enzymes to the pilot plant stage. This research can be expanded upon to exploit the big datasets generated as part of the progression of biologics through the development pipeline to further optimize production outcomes. Over the coming months, data from the project will be used to probe which approaches are amenable to which processes and, as a result, more amenable to various economic simulations. The computed optimization objective for the HIT must include the cost of acquiring, storing, and analyzing data to construct these predictive models, alongside the expected commercial reward of choosing an optimally ranked candidate. In this vein, perspective must be taken in the probable future price, capability outputs, and ownership issues of increasingly sophisticated data analysis software as superstructures become more frequent. It is frequently stated that decisions made to reduce production costs are data-driven, but that is not because more economically or energetically costly experiments or production methods are employed; to truly evaluate production steps, dynamic energy, and economic models need to become more commonplace. Conversion of process quality approaches from large questionnaires, risk analysis, and expert opinion-driven methods to statistical and thus more reliable approaches is an area of future research in analytics used herein.
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Open Access July 20, 2021

Quality of Experience (QoE) and Network Performance Modelling for Multimedia Traffic

Abstract This research explores the complex relationship between user-perceived Quality of Experience (QoE) and underlying network performance for multimedia traffic. As video streaming, online gaming, and interactive media dominate modern networks, ensuring consistent QoE has become a key challenge. The study develops a network performance model that integrates objective Quality of Service (QoS) [...] Read more.
This research explores the complex relationship between user-perceived Quality of Experience (QoE) and underlying network performance for multimedia traffic. As video streaming, online gaming, and interactive media dominate modern networks, ensuring consistent QoE has become a key challenge. The study develops a network performance model that integrates objective Quality of Service (QoS) parameters—such as delay, jitter, packet loss, and throughput—with subjective QoE metrics like Mean Opinion Score (MOS) and perceptual quality indices. Using simulation-based and analytical approaches, the paper evaluates how network conditions affect multimedia traffic behavior and user satisfaction. The results highlight critical thresholds for QoE degradation, enabling predictive modeling for adaptive multimedia delivery and real-time optimization. This work contributes to designing intelligent, user-centered network management systems capable of balancing resource efficiency and end-user satisfaction.
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