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Open Access August 26, 2025

The association between serum α1-AGP and chronic kidney disease among US female ages 20 to 49 years: Results from the 2015-2018 National Health and Nutrition Survey

Abstract Background: Chronic kidney disease (CKD) affects over 35.5 million US adults. Serum α1-acid glycoprotein (α1-AGP), an acute-phase protein, exhibits anti-inflammatory properties in animal models, but its association with CKD in younger women remains underexplored. This study investigated the relationship between serum α1-AGP and CKD risk in US women aged 20–49 years. Methods: This [...] Read more.
Background: Chronic kidney disease (CKD) affects over 35.5 million US adults. Serum α1-acid glycoprotein (α1-AGP), an acute-phase protein, exhibits anti-inflammatory properties in animal models, but its association with CKD in younger women remains underexplored. This study investigated the relationship between serum α1-AGP and CKD risk in US women aged 20–49 years. Methods: This nationally representative cross-sectional study used data on female adults in the US aged 20–49 years from the National Health and Nutrition Examination Survey 2015–2018 cycles. 2,137 individuals were included in the study after excluding individuals without serum α1-AGP, urine albumin, and creatinine data. Multivariate logistic regression models evaluated the association between serum α1-AGP and CKD. Moreover, we performed stratified and interaction analyses to see if the relationship was stable in different subgroups. Results: Among 2,137 participants (mean age 34.6 years, mean eGFR 111.7 mL/min/1.73 m²), CKD prevalence was 8.8% (n=188). Higher serum α1-AGP levels were associated with lower CKD risk in the fully adjusted model (OR 0.37, 95% CI 0.16–0.84, P = 0.017), with a dose-response trend across quartiles (P = 0.041). The association was stronger in women aged 40–49 years (OR 0.20, 95% CI 0.05–0.76) and Mexican Americans (OR 0.07, 95% CI 0.01–0.56), though interaction terms were not significant (P > 0.05). Conclusions: Higher serum α1-AGP levels are associated with lower CKD prevalence in young women, suggesting a protective role. Longitudinal studies are needed to confirm causality and explore α1-AGP as a biomarker for CKD risk stratification.
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Open Access June 26, 2025

Mathematical modelling of the impact of HIV prevention strategies among female sex workers on public health in Burkina Faso

Abstract This article presents a mathematical model designed to simulate the impact of targeted interventions aimed at preventing HIV transmission among female sex workers (FSWs) and their clients, while also analyzing their effects on the health of the general population. The compartmental model distinguishes between high-risk populations (FSWs and their clients) and low-risk populations (sexually active [...] Read more.
This article presents a mathematical model designed to simulate the impact of targeted interventions aimed at preventing HIV transmission among female sex workers (FSWs) and their clients, while also analyzing their effects on the health of the general population. The compartmental model distinguishes between high-risk populations (FSWs and their clients) and low-risk populations (sexually active men and women in the general population), and links prevention efforts in high-risk groups to the evolution of the epidemic in the low-risk population. The fundamental properties of the model, such as the positivity of solutions and the boundedness of the system, have been verified, and the basic reproduction number R0 has been calculated. Finally, the stability of the model was studied using Varga’s theorem and the Lyapunov method. Simulation results show that targeted prevention among FSWs and their clients reduces HIV incidence in the general population. This framework provides a valuable tool for guiding policymakers in the design of effective strategies to combat the epidemic, especially relevant in the context of suspension of USAID funding.
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Open Access March 05, 2024

Risk Factors of Vitamin D Insufficiency/Deficiency among a sample of Egyptian Females in Child Bearing Period

Abstract Background: Vitamin D plays an important role in the development of bone health and possibly non-communicable diseases. Arab countries had made their own national studies to assess serum vitamin D level among women, yet in Egypt there is no national survey done. The aim of the current study was to identify risk factors affecting vitamin D level among Egyptian females during the [...] Read more.
Background: Vitamin D plays an important role in the development of bone health and possibly non-communicable diseases. Arab countries had made their own national studies to assess serum vitamin D level among women, yet in Egypt there is no national survey done. The aim of the current study was to identify risk factors affecting vitamin D level among Egyptian females during the child-bearing period. Subjects and methods: A total of 100 healthy adult females in their childbearing period who were attending a Family Medicine Center were included in our study. The age of the included women ranged from 19 to 49 years old with a mean age of 34 (SD 8.47) years. The majority of participants had deficiency (43%) and insufficiency (13%) of vitamin D level. Results: Unemployed women were more likely to have vitamin D deficiency than employed women (P<0.05). Participants who were exposed to sun ˃30 minutes/day were more likely to have sufficient vitamin D level (P<0.05). All participants who consume fish ≥3 times/week had sufficient vitamin D level. Therefore, there was a statistically significance association between a number of consuming fish/week and vitamin D3 level groups. Also, there was statistically significant association between number of consumed milk cups/day and vitamin D3 level groups. All participants who drink 2 cups of milk have sufficient vitamin D level. No statistically significance association was found between using multivitamins and vitamin D3 level groups. Conclusion: Unemployment, low fish consumption and infrequent sun exposure were significant risk factors for vitamin D deficiency. Future research on the role of multivitamins supplements in improving vitamin D nutrition is warranted.
Article
Open Access February 27, 2024

Clinical characteristics of patients with multiple respiratory viruses during the COVID-19 pandemic period

Abstract Respiratory virus co-infections have been suggested to happen frequently and exacerbate patients’ conditions, but little is known about the detailed rates and the combinations of viruses during the COVID-19 pandemic period. A total of 255 symptomatic patients who underwent multiplex PCR tests were analyzed, and it was found that 6 (6/255=2.4%) patients were infected with multiple viruses. The [...] Read more.
Respiratory virus co-infections have been suggested to happen frequently and exacerbate patients’ conditions, but little is known about the detailed rates and the combinations of viruses during the COVID-19 pandemic period. A total of 255 symptomatic patients who underwent multiplex PCR tests were analyzed, and it was found that 6 (6/255=2.4%) patients were infected with multiple viruses. The patients ranged in age from 1 to 38 years, and one female patient was pregnant. Of the 6 patients, 4 had fever, and 5 had human rhinovirus/enterovirus and another virus. These data suggested that the rate of respiratory virus co-infection was low, and the combination of SAS-CoV-2 and other viruses was rare even during the COVID-19 pandemic.
Commentary
Open Access October 08, 2023

Correlation of Thyroid Gland Functions with Menstrual Patterns amongst Infertile and Fertile Women Attending a Tertiary Care Hospital in North-Central Nigeria

Abstract A regular menstrual cycle is important to maintain a woman’s fertility. This cycle has been linked to optimal function of the thyroid gland in the production of its hormones. Disturbance of thyroid gland functions could result to female infertility due to changes in menstrual patterns. Aim of this research was to determine the correlation between thyroid gland functions and menstrual patterns amongst infertile and fertile women attending a tertiary care hospital in North-Central Nigeria. This comparative, cross-sectional study recruited 106 women who visited the hospital's Gynecology Clinic and Family Planning Clinic. 53 of the 106 patients were women with a history suggestive of either primary or secondary infertility and the remaining 53 women with no history of infertility served as the control. A well-structured questionnaire was used to obtain data on the patients’ menstrual patterns. Anthropometric data were measured and obtained. Collected blood samples were analyzed using Enzyme-Linked Immunosorbent Assay (ELISA) technique to determine the serum levels of thyroid hormones. All obtained data was analyzed, and the level of significance was set at p<0.05, at a 95% confidence interval. 33 patients had menstrual anomalies (78.8% infertile women; 21.2% fertile women who served as control, p=0.012). The incidence of menstrual anomalies in the infertile women group and control group was 7.5% versus 0.0% for amenorrhea; 20.8% versus 5.7% for menorrhagia; 9.4% versus 7.5% for oligomenorrhea; 7.5% versus 0.0% for hypomenorrhea; nil polymenorrhea for both groups; and 50.9% versus 86.8% for normal menstrual patterns. Ten (9.43%) patients were diagnosed with thyroid dysfunctions (80% in infertile group; 20% in control group, p [...] Read more.
A regular menstrual cycle is important to maintain a woman’s fertility. This cycle has been linked to optimal function of the thyroid gland in the production of its hormones. Disturbance of thyroid gland functions could result to female infertility due to changes in menstrual patterns. Aim of this research was to determine the correlation between thyroid gland functions and menstrual patterns amongst infertile and fertile women attending a tertiary care hospital in North-Central Nigeria. This comparative, cross-sectional study recruited 106 women who visited the hospital's Gynecology Clinic and Family Planning Clinic. 53 of the 106 patients were women with a history suggestive of either primary or secondary infertility and the remaining 53 women with no history of infertility served as the control. A well-structured questionnaire was used to obtain data on the patients’ menstrual patterns. Anthropometric data were measured and obtained. Collected blood samples were analyzed using Enzyme-Linked Immunosorbent Assay (ELISA) technique to determine the serum levels of thyroid hormones. All obtained data was analyzed, and the level of significance was set at p<0.05, at a 95% confidence interval. 33 patients had menstrual anomalies (78.8% infertile women; 21.2% fertile women who served as control, p=0.012). The incidence of menstrual anomalies in the infertile women group and control group was 7.5% versus 0.0% for amenorrhea; 20.8% versus 5.7% for menorrhagia; 9.4% versus 7.5% for oligomenorrhea; 7.5% versus 0.0% for hypomenorrhea; nil polymenorrhea for both groups; and 50.9% versus 86.8% for normal menstrual patterns. Ten (9.43%) patients were diagnosed with thyroid dysfunctions (80% in infertile group; 20% in control group, p=0.046). Six (18.2%) out of 33 women with menstrual anomalies were diagnosed with thyroid dysfunction. Five (83.3%) out of these 6 women with both menstrual anomalies and diagnosed thyroid dysfunction were infertile while only one (16.7%) was fertile. Thyroid gland dysfunction correlates strongly with abnormal menstrual patterns, which implies that it is vital to evaluate thyroid hormone levels in blood serum in the course of treating menstrual irregularities and female infertility. Early detection of thyroid dysfunction is important in achieving a positive treatment outcome for female infertility.
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Open Access October 29, 2022

Patient Perspectives on Factors Influencing Initiation of Gynecologic Care

Abstract Addressing adolescent and sexual reproductive healthcare is essential to providing young patients with the resources they need to navigate and empower themselves with. However, there is limited data about how often this occurs. Several studies have previously indicated that there is a large gap in accessing this gap in low-income neighborhoods. Our study aims to identify the establishment of [...] Read more.
Addressing adolescent and sexual reproductive healthcare is essential to providing young patients with the resources they need to navigate and empower themselves with. However, there is limited data about how often this occurs. Several studies have previously indicated that there is a large gap in accessing this gap in low-income neighborhoods. Our study aims to identify the establishment of gynecologic care among adolescent cisgender women and elucidate potential reasons for seeking or not seeking out care. We approached women in the pediatric emergency room that matched the inclusion criteria set out. Qualitative surveys were conducted until thematic saturation was reached and a cross-section study design was employed. Interviews were analyzed through modified ground theory. The study was conducted at the pediatric emergency department at University Hospital located in Newark, NJ. In 2018 estimates, the Newark population consists of 47.0% Black and 39.2% Hispanic or Latinos. Semi-structured interviews were conducted with 27 cisgendered, English-speaking females between ages 18 to 25 presenting to the pediatric emergency room who may or may not have previously established primary care with a gynecologist. Transcriptions were analyzed using modified grounded theory and themes were identified using inductive coding of patient interviews.
Article
Open Access October 28, 2022

Branch Retinal Vein Occlusion: A Case Report

Abstract To report a case of a major branch retinal vein occlusion (BRVO) in the superotemporal region with superior macular involvement and a review of its natural history. This is a retrospective case presentation of a 49-year-old African Caribbean female patient presented to Accident and Emergency with unilateral persistent acute history of reduced central vision of left eye for 10 days with no other [...] Read more.
To report a case of a major branch retinal vein occlusion (BRVO) in the superotemporal region with superior macular involvement and a review of its natural history. This is a retrospective case presentation of a 49-year-old African Caribbean female patient presented to Accident and Emergency with unilateral persistent acute history of reduced central vision of left eye for 10 days with no other associated symptoms. Treatment options included using scatter (pan-retinal) laser photocoagulation followed by intravitreal injections as the area of non-perfusion is >5-disc area. It is warranted to understand the risk factors associated with BRVO and to develop appropriate treatment and follow-up plans.
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Case Report
Open Access December 13, 2025

Clinical Characteristics of Block-Confirmed Sacroiliac Joint Arthropathy: Referral Pain Distribution, Triggering Positions, and Provocative Maneuvers

Abstract Background: The sacroiliac joint (SIJ) plays a crucial role in transmitting axial loads and maintaining pelvic stability. Sacroiliac joint arthropathy (SIJA) accounts for 10%–30% of low back pain cases but remains underrecognized due to overlapping pain referral patterns and nonspecific imaging findings. Diagnosis relies primarily on characteristic pain distribution and provocative [...] Read more.
Background: The sacroiliac joint (SIJ) plays a crucial role in transmitting axial loads and maintaining pelvic stability. Sacroiliac joint arthropathy (SIJA) accounts for 10%–30% of low back pain cases but remains underrecognized due to overlapping pain referral patterns and nonspecific imaging findings. Diagnosis relies primarily on characteristic pain distribution and provocative maneuvers, with image-guided intra-articular block serving as the diagnostic gold standard. This study aimed to characterize the clinical profile of block-confirmed SIJA, emphasizing referral pain distribution, triggering position, and provocative test responses. Methods: A cross-sectional study was conducted on 98 patients with diagnostic block–confirmed SIJA at Siloam Hospital Lippo Village, Indonesia. Demographic data, referral pain sites, sitting duration, and results of FABER, compression, and distraction tests were analyzed descriptively. Results: The mean age was 52.07 ± 14.17 years, with 72.4% females. Referral pain most frequently involved the lower back (28.6%) and thigh (28.6%), with occasional extension to the groin (8.2%) or calf (4.1%). Over half of patients (55.1%) reported sitting more than six hours daily. Pain was predominantly triggered during sit-to-stand transitions (85.7%) and while sitting (74.5%). SIJ tenderness (98.0%) and FABER positivity (75.5%) were most consistent. Conclusion: The dominant referral pain in SIJA involves the lower back and posterior thigh. Sit-to-stand transition is the most frequent triggering position, while FABER testing demonstrates the highest diagnostic yield among provocative maneuvers. These consistent patterns may serve as practical clinical indicators to improve diagnostic accuracy in suspected SIJ-related pain.
Article
Open Access November 28, 2025

Determinants of the Carotid Tortuosity Index: Evidence from Digital Subtraction Angiography

Abstract Introduction: Stroke remains one of the leading causes of death and disability worldwide, with ischemic stroke accounting for most cases. Structural vascular factors such as carotid artery tortuosity have gained attention as potential markers of vascular aging and cerebrovascular risk. The carotid tortuosity index (CTI), defined as the ratio of actual vessel length to the straight-line [...] Read more.
Introduction: Stroke remains one of the leading causes of death and disability worldwide, with ischemic stroke accounting for most cases. Structural vascular factors such as carotid artery tortuosity have gained attention as potential markers of vascular aging and cerebrovascular risk. The carotid tortuosity index (CTI), defined as the ratio of actual vessel length to the straight-line distance between two fixed points, provides a quantitative measure of arterial curvature. A CTI value of ≥1.2 indicates pathological tortuosity. Although noninvasive modalities such as CTA and MRA are frequently used, digital subtraction angiography (DSA) remains the gold standard for evaluating vessel geometry due to its higher spatial precision. This study aimed to determine the association of age, sex, and hypertension with CTI measured by DSA. Methods: A cross-sectional study was conducted from November to December 2025 at the Neurointervention Clinic, RS Pelni Jakarta, Indonesia, involving 61 adult patients who underwent carotid DSA. CTI was measured bilaterally using digital imaging software and classified as <1.2 (non-tortuous) or ≥1.2 (tortuous). Clinical data, including age, sex, and hypertension status, were collected from medical records and analyzed using bivariate tests. Results: Older age (≥65 years), female sex, and hypertension were significantly associated with higher CTI values on both carotid sides. Tortuosity was more common among hypertensive patients and elderly females, indicating the influence of vascular remodeling and chronic hemodynamic stress. Conclusion: Carotid tortuosity increases with age, hypertension, and female sex. DSA-based CTI measurement provides a reliable and precise approach for evaluating vascular changes associated with cerebrovascular risk.
Article
Open Access October 27, 2025

Electronic Cigarette Perception in Baltimore High Schools

Abstract Background: Electronic cigarette (e-cigarette) use among adolescents is a growing public health concern, particularly in low-income and Black communities. However, little is known about how social determinants of health shape e-cigarette perceptions in this population. Aims: This study examined social determinants associated with perceptions of e-cigarette safety among Baltimore high [...] Read more.
Background: Electronic cigarette (e-cigarette) use among adolescents is a growing public health concern, particularly in low-income and Black communities. However, little is known about how social determinants of health shape e-cigarette perceptions in this population. Aims: This study examined social determinants associated with perceptions of e-cigarette safety among Baltimore high school students. Methods: A cross-sectional survey (CEASE Youth: School Survey) was conducted with 604 Baltimore high school students aged 14–20. Participants completed a questionnaire assessing perceptions of e-cigarette safety, as well as parental education, race/ethnicity, parental employment, household composition, and community tobacco use. Results: Higher parental education was associated with lower perceived e-cigarette safety among students. Students in higher grades also reported lower perceived e-cigarette safety. In contrast, male students—particularly those in upper grades—were more likely to perceive e-cigarettes as safe. Race/ethnicity, household composition, parental employment, and community tobacco exposure were not associated with perceived e-cigarette safety. Conclusion: Higher parental education, female gender, and being in higher grades were associated with perceiving e-cigarettes as unsafe. These findings highlight the need for targeted interventions to address vaping perceptions among youth in urban settings.
Article
Open Access June 25, 2025

Deconstructing Soccer Footwear: An Anatomical Review with Implications for Female Athlete-Specific Design

Abstract This review article provides a comprehensive anatomical analysis of soccer footwear, delving into the intricate structure and functional roles of its constituent components, including the upper, heel counter, tongue, toe box, outsole/sole plate, studs, and insole. Manufacturing processes influencing these structural elements are also discussed. Current market offerings and patented innovations in [...] Read more.
This review article provides a comprehensive anatomical analysis of soccer footwear, delving into the intricate structure and functional roles of its constituent components, including the upper, heel counter, tongue, toe box, outsole/sole plate, studs, and insole. Manufacturing processes influencing these structural elements are also discussed. Current market offerings and patented innovations in soccer cleat technology are examined through a biomechanical lens, highlighting their intended functions and limitations. A critical synthesis of existing knowledge underscores the anatomical and biomechanical distinctions between male and female athletes' feet, arguing for the necessity of sex-specific footwear design. This review culminates in emphasizing the imperative for specifically engineered soccer footwear for female athletes to optimize performance, enhance comfort, and mitigate the elevated risk of lower extremity injuries prevalent in the female game, thereby identifying crucial directions for future research in sports biomechanics and footwear engineering.
Commentary
Open Access May 30, 2025

Advancing Women's Soccer: Historical Growth and Challenges Concerning Athlete Health and Diversity

Abstract This exploratory review article synthesizes existing literature on the evolution and increasing significance of women's soccer, particularly in the United States. While acknowledging the sport's progress and the achievements of the U.S. Women's National Team (USWNT), it critically examines two key challenges that impede further advancement: the alarmingly high incidence of knee injuries among [...] Read more.
This exploratory review article synthesizes existing literature on the evolution and increasing significance of women's soccer, particularly in the United States. While acknowledging the sport's progress and the achievements of the U.S. Women's National Team (USWNT), it critically examines two key challenges that impede further advancement: the alarmingly high incidence of knee injuries among female players and the persistent underrepresentation of Black women. The review highlights the biomechanical factors contributing to these issues, emphasizing the need for footwear designed to accommodate the specific anatomical and functional requirements of female athletes. Furthermore, it explores the systemic barriers that contribute to the lack of diversity within the sport, advocating for equitable opportunities and support for Black women. This review concludes by underscoring the necessity for innovative, interdisciplinary approaches to ensure the continued growth and well-being of all participants in women's soccer, and identifies critical areas for future research in kinesiology and related fields.
Review Article
Open Access March 18, 2025

ACL Tears and the Female Athlete

Abstract The anterior collateral ligament (ACL) is one of four ligaments in the knee, connecting the tibia and femur and acting as a key stabilizer. Factors influencing these injuries include playing surface, training programs, athlete strength, technique, and gender. Female athletes are at a higher risk of ACL injuries, being four to nine times more likely than males, often due to differences in [...] Read more.
The anterior collateral ligament (ACL) is one of four ligaments in the knee, connecting the tibia and femur and acting as a key stabilizer. Factors influencing these injuries include playing surface, training programs, athlete strength, technique, and gender. Female athletes are at a higher risk of ACL injuries, being four to nine times more likely than males, often due to differences in biomechanics and training patterns. It ss important that rehab focuses on both legs, as overworking the injured leg increases the risk of injuries elsewhere. Prevention training, such as proprioceptive-balance and plyometric agility training, has been shown effectiveness in minimizing ACL injuries. Despite some limitations in research, these programs highlight the importance of improved training techniques. Kinesio taping might help reduce pain but lacks strong evidence for preventing ACL tears.
Review Article
Open Access March 11, 2025

Why High Income Fails to Reduce E-Cigarette Use: The Knowledge-Attitude Paradox in the SMOKES Study

Abstract Background: Electronic cigarette (e-cigarette) use and vaping tobacco have increased rapidly worldwide, raising concerns about their health effects, social acceptability, and regulatory challenges. In many countries, e-cigarettes are more commonly used by individuals from higher socioeconomic status (SES) backgrounds, who, in theory, should have greater knowledge about e-cigarettes and [...] Read more.
Background: Electronic cigarette (e-cigarette) use and vaping tobacco have increased rapidly worldwide, raising concerns about their health effects, social acceptability, and regulatory challenges. In many countries, e-cigarettes are more commonly used by individuals from higher socioeconomic status (SES) backgrounds, who, in theory, should have greater knowledge about e-cigarettes and their associated risks. However, it remains unclear why a group with more knowledge about e-cigarette risks would also hold more positive attitudes toward vaping and exhibit higher usage rates — a phenomenon that may represent a knowledge-behavior paradox. Understanding this paradox, along with the complex relationships between e-cigarette knowledge, attitudes, and behaviors, is critical for informing effective public health interventions, campaigns, social media messaging, and regulatory policies. Objectives: This study aimed to evaluate the complex relationship between SES, e-cigarette knowledge, pro-vaping attitudes, and e-cigarette use. Methods: The SMOKES Study (Study of Measurement of Knowledge and Examination of Support for Tobacco Control Policies) used a multi-center, cross-sectional design, collecting data from 2,403 college and university students across 15 provinces in Iran (covering nearly half of the country's provinces). The survey measured family income, age, sex, ethnicity, e-cigarette use, knowledge, and attitudes. Structural Equation Modeling (SEM) was employed to examine the interrelations between SES, knowledge, attitudes, and behavior, while adjusting for age, sex, and ethnic minority status. Results: SEM analysis confirmed the hypothesized paradox. Although greater knowledge about e-cigarettes was linked to less favorable attitudes toward vaping and lower use, pro-vaping attitudes emerged as the strongest predictor of vaping behavior, while knowledge played a weaker protective role. Notably, individuals with higher SES simultaneously showed higher knowledge and, paradoxically, more pro-e-cigarette attitudes and greater usage. Female students and ethnic minority students reported higher correct knowledge and lower pro-vaping attitudes and use. Although age and higher family income were associated with more favorable attitudes, they did not directly predict vaping behavior. These results suggest that for higher SES individuals, poor knowledge is not the main driver of e-cigarette use; rather, their pro-e-cigarette attitudes, which seem to outweigh the influence of knowledge, play a key role. Conclusions: Although individuals from higher SES backgrounds report greater correct knowledge about e-cigarettes, this knowledge does not necessarily translate into reduced positive attitudes or lower usage. This study highlights the complexity of these paradoxical effects and suggests that public health strategies need to go beyond simple education and knowledge-based interventions. Targeted approaches should address industry messaging, challenge misconceptions, and strengthen regulatory efforts to reduce e-cigarette use among young adults, including those from higher SES backgrounds.
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Original Article
Open Access February 13, 2025

Psychosocial Correlates of Childhood Body Mass Index: Racial and Ethnic Differences

Abstract Objective: To examine racial/ethnic differences in the associations of family socioeconomic status (SES), neighborhood SES, and inhibitory control with body mass index (BMI) in 9-10-year-old children using data from the Adolescent Brain Cognitive Development (ABCD) study. Methods: This cross-sectional study included a diverse sample of children aged 9-10 years, representing [...] Read more.
Objective: To examine racial/ethnic differences in the associations of family socioeconomic status (SES), neighborhood SES, and inhibitory control with body mass index (BMI) in 9-10-year-old children using data from the Adolescent Brain Cognitive Development (ABCD) study. Methods: This cross-sectional study included a diverse sample of children aged 9-10 years, representing non-Latino White, Black, Latino, Asian, and Other racial/ethnic groups. BMI was the primary outcome. Key predictors were family SES, neighborhood SES, and inhibitory control. Multivariable regression models were stratified by race/ethnicity to identify group-specific associations. Results: Race/ethnic groups differed in psychosocial correlates of childhood BMI at age 9 and 10. Among non-Latino White children, higher family income (B = -0.086, p < 0.001), higher parental education (B = -0.069, p < 0.001), and living in a married household (B = -0.079, p < 0.001) were associated with lower BMI. Additionally, the presence of healthy food options in the zip code (B = -0.030, p = 0.032) was linked to lower BMI, while lack of planning (B = 0.032, p = 0.030) was associated with higher BMI. For non-Latino Black children, positive urgency (B = -0.068, p = 0.022) was negatively associated with BMI, while other factors such as family SES and neighborhood SES did not show significant associations. For Latino children, higher family income (B = -0.093, p = 0.001) and parental education (B = -0.099, p < 0.001) were associated with lower BMI. In this group, male gender (B = 0.043, p = 0.033) was associated with higher BMI. Among Asian children, higher family income (B = -0.199, p = 0.006) and parental education (B = -0.144, p = 0.037) were significantly associated with lower BMI. For children in the "Other" racial/ethnic category, higher family income (B = -0.101, p = 0.023), living in a married household (B = -0.076, p = 0.026), and higher median income in the zip code (B = -0.083, p = 0.013) were associated with lower BMI. In this group, male children had lower BMI compared to females (B = -0.089, p = 0.001). Conclusion: The findings highlight substantial racial/ethnic differences in the psychosocial and socioeconomic correlates of BMI in children. There is a need for tailored interventions that target social determinants of childhood high BMI. One size does not fit all.
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Open Access January 23, 2025

Trauma and Early Puberty May Be Stronger Predictors of Early Tobacco Initiation in Girls Compared to Boys

Abstract Objective: This study investigates the pathways linking socioeconomic status (SES), trauma, early puberty, and tobacco use, with a focus on how these relationships differ by sex. Using data from the Adolescent Brain Cognitive Development (ABCD) study, we explore how SES and race contribute to trauma exposure, which in turn may influence early puberty and tobacco use. The study also examines [...] Read more.
Objective: This study investigates the pathways linking socioeconomic status (SES), trauma, early puberty, and tobacco use, with a focus on how these relationships differ by sex. Using data from the Adolescent Brain Cognitive Development (ABCD) study, we explore how SES and race contribute to trauma exposure, which in turn may influence early puberty and tobacco use. The study also examines potential mediating effects of trauma and early puberty on the association between SES and tobacco use, while comparing these pathways for males and females. Methods: Data were drawn from the ABCD study, and structural equation modeling (SEM) was employed to test direct and indirect pathways between SES, trauma, early puberty, and tobacco use. The sample was stratified by sex to assess differences in these relationships for males and females. Key predictors included SES, race, and age, while outcomes were trauma, early puberty, and tobacco use. The model assessed mediating effects of trauma and early puberty on tobacco use. Results: Trauma was a significant predictor of early puberty for females (B = 0.032, SE = 0.015, p = 0.039) but not males. Early puberty was significantly linked to tobacco use for females (B = 0.048, SE = 0.015, p = 0.001) but not for males. Additionally, trauma had an effect on tobacco use among females (B = 0.048, SE = 0.014, p < 0.001) but not males. Lower SES was significantly associated with higher trauma exposure for both males (B = -0.109, SE = 0.014, p < 0.001) and females (B = -0.110, SE = 0.015, p < 0.001). Conclusions: The findings suggest that trauma and early puberty play more significant roles in the pathways from SES to tobacco use for females than for males. While trauma and early puberty are crucial mediators for females, these factors are less predictive for males. These results highlight the importance of sex-specific interventions targeting trauma and early puberty as pathways to early tobacco use.
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Article
Open Access November 19, 2024

Social Epidemiology of Dual Use of Electronic and Combustible Cigarettes Among U.S. Adults: Insights from the Population Assessment of Tobacco and Health (PATH) Study

Abstract Background: The dual use of e-cigarettes and combustible cigarettes poses significant public health concerns due to the compounded risks associated with the use of both products. Understanding the predictors of dual use can inform targeted interventions and tobacco control strategies aimed at reducing nicotine dependence and health risks among adults. Objective: This study [...] Read more.
Background: The dual use of e-cigarettes and combustible cigarettes poses significant public health concerns due to the compounded risks associated with the use of both products. Understanding the predictors of dual use can inform targeted interventions and tobacco control strategies aimed at reducing nicotine dependence and health risks among adults. Objective: This study aims to identify the sociodemographic predictors of dual use of e-cigarettes and combustible cigarettes among U.S. adults using baseline data from the Population Assessment of Tobacco and Health (PATH) Study. Methods: We analyzed baseline data from the PATH Study, focusing on adult participants who reported the use of both e-cigarettes and combustible cigarettes. Logistic regression models were used to identify the associations between dual use and key sociodemographic variables, including age, gender, race/ethnicity, and education level. Results: The analysis revealed that dual use of e-cigarettes and combustible cigarettes was predominantly observed among young, female, non-Latino, White, and highly educated adults. Younger adults were more likely to engage in dual use compared to older age groups. Females showed higher rates of dual use compared to males. Non-Latino White individuals were more likely to be dual users than individuals from other racial/ethnic backgrounds. Additionally, higher educational attainment was associated with increased dual use, contrary to traditional smoking patterns. Conclusion: The findings highlight specific demographic groups that are at higher risk of dual use of e-cigarettes and combustible cigarettes, particularly younger, highly educated, non-Latino White females. These insights suggest the need for tailored public health interventions that address the unique needs and behaviors of these populations. Future research should explore the underlying motivations and contextual factors contributing to dual use to enhance the effectiveness of tobacco control policies and cessation programs.
Article
Open Access October 31, 2024

The Long Shadow of Early Poverty: Poverty at Birth, Epigenetic Changes at Age 15, And Youth Outcomes at Age 22

Abstract Background: Early life socioeconomic conditions and race/ethnicity are critical determinants of long-term health and behavioral outcomes. Epigenetic changes, particularly those measured by the GrimAge biomarker, may mediate the impact of these early adversities on later life outcomes. This study investigates the relationships between race/ethnicity, poverty at birth, epigenetic aging at age [...] Read more.
Background: Early life socioeconomic conditions and race/ethnicity are critical determinants of long-term health and behavioral outcomes. Epigenetic changes, particularly those measured by the GrimAge biomarker, may mediate the impact of these early adversities on later life outcomes. This study investigates the relationships between race/ethnicity, poverty at birth, epigenetic aging at age 15, and subsequent self-rated health, school discipline, depression, and school dropout at age 22. We explored sex differences in these paths. Methods: Data were drawn from the Fragile Families and Child Wellbeing Study (FFCWS), which included 733 youth with comprehensive follow-up data up to age 22. Structural Equation Modeling (SEM) was employed to assess the pathways from race/ethnicity and poverty at birth to epigenetic aging (GrimAge) at age 15, and subsequently to self-rated health and school discipline at age 22. The model controlled for potential confounders including sex, family structure, and parental education. Results: Race/ethnicity and poverty at birth were significantly associated with higher GrimAge scores at age 15 (p < 0.05). Higher GrimAge scores were predictive of poorer self-rated health (β = -0.08, p < 0.05) and increased instances of school discipline (β = 0.13, p < 0.01) at age 22. The indirect effects of race/ethnicity and poverty at birth on self-rated health and school discipline through GrimAge were also significant (p < 0.05), suggesting that epigenetic aging partially mediates these relationships. Sex differences were also observed. Poverty at birth predicted faster epigenetic aging at age 15 for males not females. We also observed that faster epigenetic aging at age 15 was predictive of school discipline of male not female participants at age 22. In contrast, faster epigenetic aging at age 15 was predictive of self-rated health (SRH) of female not male participants at age 22. Conclusions: This study provides evidence that with some sex differences, race/ethnicity and poverty at birth contribute to accelerated epigenetic aging (GrimAge) by age 15, which in turn predicts poorer self-rated health and increased school discipline issues by age 22. These findings emphasize the importance of early interventions targeting social determinants to mitigate long-term health and behavioral disparities. Addressing these early life conditions is crucial for improving health equity and outcomes in young adulthood.
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Open Access October 12, 2024

Case Report: Unmasking Meigs’ Syndrome and the resolution of persistent Ascites after Oophorectomy in an 18-year-old Female at Cleveland Specialized Clinic Wampewo

Abstract Introduction: Meigs’ Syndrome, characterized by a benign ovarian tumor that leads to ascites and occasionally pleural effusion, is a rare condition that often presents significant diagnostic challenges, particularly in young female patients. This case report highlights an 18-year-old-female with persistent gross ascites and pleural effusion unresponsive to diuretics, paracentesis, and [...] Read more.
Introduction: Meigs’ Syndrome, characterized by a benign ovarian tumor that leads to ascites and occasionally pleural effusion, is a rare condition that often presents significant diagnostic challenges, particularly in young female patients. This case report highlights an 18-year-old-female with persistent gross ascites and pleural effusion unresponsive to diuretics, paracentesis, and thoracentesis. Despite extensive diagnostics evaluations including negative results from several tumor makers, histology and pathology reports, Liver and renal function tests, abdominal CT scans, ECHO, Ecg, Chest X-rays and HBV screening PCR test, the underlying causes of the ascites and pleural effusion remained elusive. The diagnosis was only made following an exploratory laparotomy, which revealed the presence of bilateral benign ovarian tumors. Subsequent bilateral Oophorectomy and Salpingectomy resulted in the complete resolution of the ascites. This case underscores not only the importance of considering ovarian pathology in young females with unexplained ascites but also highlights the critical role of exploratory laparotomy when non-invasive diagnostics fails to provide answers. Conclusion: This case emphasizes the need for a high index of suspicious for Meigs’ Syndrome in young females presenting with persistent ascites and pleural effusion, even when standard diagnostic tests yield negative results. It highlights the potential necessity of surgical intervention when other diagnostic approaches fail to identify the underlying causes. Clinicians should be aware of this condition and consider it in their differential diagnosis to ensure appropriate and effective management
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Case Report
Open Access October 05, 2024

Symbolic Splendour: Integrating Adinkra Symbols in Ghana’s Most Beautiful Set Design

Abstract This study explores the integration of Adinkra symbols into the set design of Ghana’s Most Beautiful (GMB), a popular beauty pageant and reality TV show that has aired on TV3; a private television station in Ghana. GMB showcases beauty, intelligence, cultural knowledge, and traditional values, celebrating Ghana's rich cultural heritage through female contestants representing the country's diverse [...] Read more.
This study explores the integration of Adinkra symbols into the set design of Ghana’s Most Beautiful (GMB), a popular beauty pageant and reality TV show that has aired on TV3; a private television station in Ghana. GMB showcases beauty, intelligence, cultural knowledge, and traditional values, celebrating Ghana's rich cultural heritage through female contestants representing the country's diverse ethnic groups. In response to the lack of coherent Ghanaian artistic elements in previous set designs, this study employed an artistic methodology to incorporate four Adinkra symbols, Okɔdeɛ Mmɔwerɛ, Duafe, Dweninimmɛn, and Mate Masie, into the set design for the show’s eighth season. These symbols, signifying beauty, strength, wisdom, and unity respectively, were creatively integrated into a crown-like set design for the grand finale, harmonizing aesthetic trends with cultural significance. The design process was informed by rigorous research and stakeholder interviews, ensuring that the selected symbols conveyed the intended cultural messages. The results highlight the potential of traditional symbols to enhance both the cultural relevance and visual appeal of television productions. The project enriches the cultural depth of GMB production and offers a blueprint for incorporating indigenous symbols into contemporary set design. The study recommends that future productions continue exploring traditional symbols to deepen the appreciation of Ghanaian heritage and strengthen cultural identity through visual arts.
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Open Access September 22, 2024

An Appraisal of Paragraph Unity and Coherence in Writing

Abstract Good academic writing requires a good combination of cohesive ties and coherent features in the text. This study aimed to assess whether paragraph unity and coherence in writing were achieved among students of the Komenda College of Education concerning gender. Lakoff’s Theory underpinned the study. The quantitative approach and a descriptive research design were used in the study. The sample size [...] Read more.
Good academic writing requires a good combination of cohesive ties and coherent features in the text. This study aimed to assess whether paragraph unity and coherence in writing were achieved among students of the Komenda College of Education concerning gender. Lakoff’s Theory underpinned the study. The quantitative approach and a descriptive research design were used in the study. The sample size was 60 (40 males and 20 females). Level 200 students from the Komenda College of Education Department of English were selected using census techniques. The instruments used for data collection were text items and questionnaires. Paragraphs written by the students were analysed using narratives, and quantitative data was analysed using mean, standard deviation and the independent samples t-test. The study revealed that male students have a higher mean score than female students. The study also concluded that there was no significant difference between male and female students regarding achieving paragraph unity and coherence in writing. In other words, gender does not influence how paragraph unity and coherence are achieved in writing – males and females are statistically the same. It is recommended that the principals of the various colleges of education in Ghana encourage the college tutors and the Student Representative Council (SRC) leadership to introduce a programme which engages college students in competitive writing without gender barriers. This programme will ensure that students compete by writing academic papers, demonstrating their knowledge of achieving unity and coherence in writing. This programme can be done every academic year, and an equal number of males and females are presented yearly.
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Open Access July 25, 2024

Leadership Styles of Female Leaders in Management of Senior High Schools in the Central Region of Ghana

Abstract The role and contribution of women in modern organisations have been phenomenal. However, societal norms and other patriarchal values continue to stifle the progress of women leaders. The study's overall purpose was to examine the leadership styles of female leaders in managing senior high schools in the Central Region of Ghana. The study adopted non-numerical data and used a purely qualitative [...] Read more.
The role and contribution of women in modern organisations have been phenomenal. However, societal norms and other patriarchal values continue to stifle the progress of women leaders. The study's overall purpose was to examine the leadership styles of female leaders in managing senior high schools in the Central Region of Ghana. The study adopted non-numerical data and used a purely qualitative research approach. A phenomenological design supported the study framework, and the required data was collected through interviews. The target population for the study were female headmistresses and assistant headmistresses in the various Senior High Schools in the Metropolis. The study involved all six female headmistresses and eight assistant headmistresses in the Metropolis. The participants were sampled using the census to meet the study objectives. The data were analysed thematically. The study revealed that married couples use the participatory leadership style, but those who are single use the assertive style. The study also concluded that women leaders who are single and are farther from 60 years old are more likely to have problems in the discharge of their duties as leaders since men, per societal influence, will always try to resist the control of women leaders. The Ghana education service should package special incentives for women who aspire to achieve the utmost leadership role of becoming heads of senior high schools. It will motivate the young women generation. It is also recommended that women in leadership positions in the Ghana Education Service are advised to learn by updating their skills and competencies to grow in confidence and share ideas with colleagues in the same field to adopt and adapt leadership styles that have worked in other institutions to handle institutional challenges.
Review Article
Open Access July 16, 2024

Poverty Status at Birth Predicts Epigenetic Changes at Age 15

Abstract We used 15 years of follow up of 854 racially and ethnically diverse birth cohort who were followed from birth to age 15. Structural equation modeling (SEM) was used to examine the effects of race/ethnicity, maternal education, and family structure on poverty at birth, as well as the effects of poverty at birth on epigenetic changes at age 15. We also explored variations by sex. Results: [...] Read more.
We used 15 years of follow up of 854 racially and ethnically diverse birth cohort who were followed from birth to age 15. Structural equation modeling (SEM) was used to examine the effects of race/ethnicity, maternal education, and family structure on poverty at birth, as well as the effects of poverty at birth on epigenetic changes at age 15. We also explored variations by sex. Results: Our findings indicate that Black and Latino families had lower maternal education and married family structure which in turn predicted poverty at birth. Poverty at birth then was predictive of epigenetic changes 15 years later when the index child was 15. This suggested that poverty at birth partially mediates the effects of race/ethnicity, maternal education, and family structure on epigenetic changes of youth at age 15. There was an effect of poverty status at birth on DNA methylation of male but not female youth at age 15. Thus, poverty at birth may have a more salient effect on long term epigenetic changes of male than female youth. Conclusions: Further studies are needed to understand the mechanisms underlying the observed sex differences in the effects of poverty as a mechanism that connects race/ethnicity, maternal education, and family structure to epigenetic changes later in life.
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Open Access July 12, 2024

Race, Poverty Status at Birth, and DNA Methylation of Youth at Age 15

Abstract Epigenetic studies, which can reflect biological aging, have shown that measuring DNA methylation (DNAm) levels provides new insights into the biological effects of social environment and socioeconomic position (SEP). This study explores how race, family structure, and SEP (income to poverty ratio) at birth influence youth epigenetic aging at age 15. Data were obtained from the Future [...] Read more.
Epigenetic studies, which can reflect biological aging, have shown that measuring DNA methylation (DNAm) levels provides new insights into the biological effects of social environment and socioeconomic position (SEP). This study explores how race, family structure, and SEP (income to poverty ratio) at birth influence youth epigenetic aging at age 15. Data were obtained from the Future of Families and Child Wellbeing Study (FFCWS) cohort, with GrimAge used as a measure of DNAm levels and epigenetic aging. Our analysis included 854 racially and ethnically diverse participants followed from birth to age 15. Structural equation modeling (SEM) examined the relationships among race, SEP at birth, and epigenetic aging at age 15, controlling for sex, ethnicity, and family structure at birth. Findings indicate that race was associated with lower SEP at birth and faster epigenetic aging. Specifically, income to poverty ratio at birth partially mediated the effects of race on accelerated aging by age 15. The effect of income to poverty ratio at birth on DNAm was observed in male but not female youth at age 15. Thus, SEP partially mediated the effect of race on epigenetic aging in male but not female youth. These results suggest that income to poverty ratio at birth partially mediates the effects of race on biological aging into adolescence. These findings highlight the long-term biological impact of early-life poverty in explaining racial disparities in epigenetic aging and underscore the importance of addressing economic inequalities to mitigate these disparities. Policymakers should focus on poverty prevention in Black communities to prevent accelerated biological aging and associated health risks later in life. Interventions aimed at eliminating poverty and addressing racial inequities could have significant long-term benefits for public health. Future research should explore additional factors contributing to epigenetic aging and investigate potential interventions to slow down the aging process. Further studies are needed to understand the mechanisms underlying these associations and to identify effective strategies for mitigating the impact of SEP and racial disparities on biological aging.
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Open Access May 28, 2024

Mutational Analysis of Driver and Non-driver Mutations of Philadelphia Chromosome-negative Myeloproliferative Neoplasms; Diagnosis and Recent Advances in Treatment

Abstract Myeloproliferative neoplasms (MPNs) are hematological disorders affecting myeloid stem cells. They are classified as Philadelphia (Ph) chromosome positive-chronic myeloid leukemia, and Ph-negative polycythemia vera, essential thrombocythemia, primary myelofibrosis, chronic neutrophilic leukemia, chronic eosinophilic leukemia, juvenile myelomonocytic leukemia, and MPN unclassifiable. This review is mainly focused on the Ph-negative MPNs namely, PV, ET, and PMF. These affect both males and females with a slight male predominance, with patients mainly presenting in the seventh decade. Patients often present with thrombotic events resulting in complications that lower survival rates. The major driver mutations that have been identified in MPNs are JAK2 Exon 14, JAK2 Exon 12, MPL Exon 10, and CALR Exon 9. The importance of these driver mutations gives due recognition to their inclusion into the 2022 diagnostic criteria of the MPN WHO Classification. However, other non-driver mutations have also been reported, especially in triple-negative cases. These mutations lead to downstream constitutive activation of the JAK/STAT signaling pathway, as well as the MAPK, and PI3K/Akt pathways. Insights into the molecular pathogenesis of MPN and its association with JAK2, CALR, and MPL [...] Read more.
Myeloproliferative neoplasms (MPNs) are hematological disorders affecting myeloid stem cells. They are classified as Philadelphia (Ph) chromosome positive-chronic myeloid leukemia, and Ph-negative polycythemia vera, essential thrombocythemia, primary myelofibrosis, chronic neutrophilic leukemia, chronic eosinophilic leukemia, juvenile myelomonocytic leukemia, and MPN unclassifiable. This review is mainly focused on the Ph-negative MPNs namely, PV, ET, and PMF. These affect both males and females with a slight male predominance, with patients mainly presenting in the seventh decade. Patients often present with thrombotic events resulting in complications that lower survival rates. The major driver mutations that have been identified in MPNs are JAK2 Exon 14, JAK2 Exon 12, MPL Exon 10, and CALR Exon 9. The importance of these driver mutations gives due recognition to their inclusion into the 2022 diagnostic criteria of the MPN WHO Classification. However, other non-driver mutations have also been reported, especially in triple-negative cases. These mutations lead to downstream constitutive activation of the JAK/STAT signaling pathway, as well as the MAPK, and PI3K/Akt pathways. Insights into the molecular pathogenesis of MPN and its association with JAK2, CALR, and MPL mutations have identified JAK2 as a rational therapeutic target. Thus, as an approach to MPN therapy, JAK2 inhibitors, such as ruxolitinib, have been shown to effectively inhibit JAK2, and are currently in clinical trials in combination with other drug classes. This review comprehensively examines the molecular markers of the main Ph-negative MPNs, as well as diagnosis and treatment options.
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Review Article
Open Access February 12, 2024

An Appraisal of PROCESS and REACH Model on Forgiveness, Anger and Depression among Adolescents in Junior High Schools in Nanumba North Municipality, Ghana

Abstract The purpose of the study was to examine the effect of REACH and Process Models on forgiveness, anger and depression among 11- to 19-year-old adolescents in junior high schools in Bimbilla in the Northern Region of Ghana. The study employed a mixed-method design. The population for the study comprised all junior high school students totalling 3632. Of this number, 1,888 (55%) of the students were [...] Read more.
The purpose of the study was to examine the effect of REACH and Process Models on forgiveness, anger and depression among 11- to 19-year-old adolescents in junior high schools in Bimbilla in the Northern Region of Ghana. The study employed a mixed-method design. The population for the study comprised all junior high school students totalling 3632. Of this number, 1,888 (55%) of the students were males, while 1744(45%) were females. The accessible population was 1,636 from eight (8) JHSs with 952(55%) of them being boys and the remaining 684(45%) being girls. The participants were selected based on their low levels of forgiveness and high levels of anger and depression determined by the Depression Mode Scale and Anger Self-Report. Purposive and simple random sampling techniques were used to select 60 participants for the study, with each group having 20 participants. The main instruments used for the study are questionnaires (Enright Forgiveness Inventory (EFI). Anger self-report questionnaire (ASR), and Depressed Mood Scale (DMS) and semi-structured interview guide. One-way Analysis of Covariance (ANCOVA) was used to test the hypotheses. The study indicates that both the REACH model and PROCESS model have the efficacy in enhancing forgiveness among adolescents. The study also revealed that the REACH model and Process model have efficacy in reducing levels of depression among adolescent students. It is recommended that Counselling Centres should be set up by District Education Offices and the District Assemblies in the community so that students can visit the centre anytime they feel hurt. Regular seminars, lectures and symposia should be organized regularly by Counsellors and Psychologists using the efficacy of forgiveness therapies (Process and REACH Therapies) for students to be sensitized on the need to patronise forgiveness interventions. It is also recommended that the Government should provide adequate funds and support to encourage the conduct of research in forgiveness counselling since it is a new concept in Africa and Ghana in particular.
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Open Access December 28, 2023

Perspectives of Married Men and Women on Access and Use of Contraceptives in Obuasi-East District in Ghana

Abstract Family planning and the use of contraceptives have been introduced in Ghana to control the fertility rate and ensure the prevention of unplanned pregnancies. The study examined the perceptions of married men and women on the use of contraceptives, their access to information and the effects of mass media on the use of contraceptives in the Obuasi-East District. The research adopted a qualitative [...] Read more.
Family planning and the use of contraceptives have been introduced in Ghana to control the fertility rate and ensure the prevention of unplanned pregnancies. The study examined the perceptions of married men and women on the use of contraceptives, their access to information and the effects of mass media on the use of contraceptives in the Obuasi-East District. The research adopted a qualitative approach using the phenomenological case study design. Purposive and convenience sampling techniques were used to sample 15 married men and women for the study. The data was collected using interviews and presented through thematic analysis. The study revealed that participants had in-depth knowledge of contraceptives and male and female participants held different perceptions. Married men have knowledge of the types of contraceptives peculiar to both sexes. The women were familiar with condoms used by men and various types of contraceptives used by women. The most common contraceptive known and used by married men is a condom because of its effectiveness, ease of use and accessibility. The married women preferred injectables. The frequency of information from the mass media has reduced significantly compared to previous years. The study concluded that mass media has an effect on the use of contraceptives among married men and women and recommends that mass media frequently educate the general public on the use of contraceptives. Besides, information on contraceptives and their use should be diversified by media houses in the form of drama, poems, books and music to attract married couples.
Article
Open Access November 02, 2023

Oncological Disease in Metastatic Breast Neoplasia and Palliative Care: A Review

Abstract Cancer is the second cause of death worldwide, affecting one in six people, with breast cancer being the most prevalent in females. Adapting to an oncological disease entails many physical and psychological changes that affect the patient and their families. This work aims to present existing scientific research on adaptation to oncological disease and the end of life of women with metastatic [...] Read more.
Cancer is the second cause of death worldwide, affecting one in six people, with breast cancer being the most prevalent in females. Adapting to an oncological disease entails many physical and psychological changes that affect the patient and their families. This work aims to present existing scientific research on adaptation to oncological disease and the end of life of women with metastatic cancer aged between 45 and 65, framing with Acceptance and Commitment Therapy. (TAC). Fifty documents with publication dates between 2002 and 2022 were included in this study. It was found that there is much information on the topic in question, as it is a problem that affects not only women but also all the systems they are in. When faced with a terminal diagnosis, a woman faces many doubts and uncertainties, in addition to all the physical effects of the disease. Therefore, she should be accompanied by a team specialized in Palliative Care, which can provide her and her family with all the support needed in this challenging phase.
Review Article
Open Access July 23, 2023

Assessing Observing Skills of Biology Students in Selected Senior High Schools

Abstract The purpose of the study was to design and develop performance-based tasks to assess laboratory observing skills of biology students in senior high schools. The target population was all students in the nine schools within Sekondi-Takoradi Metropolis reading biology as an elective subject. The accessible population was 753 SHS 2 biology students in six schools. 261 students were randomly selected [...] Read more.
The purpose of the study was to design and develop performance-based tasks to assess laboratory observing skills of biology students in senior high schools. The target population was all students in the nine schools within Sekondi-Takoradi Metropolis reading biology as an elective subject. The accessible population was 753 SHS 2 biology students in six schools. 261 students were randomly selected from each of the six schools. These schools were of three different types, single-sex males, single-sex females, and mixed. Mean, standard deviations, frequencies, and percentages were calculated while independent sample t-tests were performed. No significant difference was noticed in levels of proficiency shown for males and females in the various schools surveyed. It is recommended that students from all types of schools and both sexes must be given an opportunity to engage in more activities at the SHS level to sharpen their observing skills.
Article
Open Access July 21, 2023

Covid-19-Associated Myopericardial Injury: A Macro and Microscopic Description

Abstract Authors describe autoptic findings of two cases whose COVID-19 diagnosis was supported by laboratory data. Both patients were Caucasian individuals of middle age (one male, 47 years old; the other a female aging 36 years) that were considered as previously healthy. Clinically they died from cardiorespiratory insufficiency while being treated in intensive care units. None of them was intubated and [...] Read more.
Authors describe autoptic findings of two cases whose COVID-19 diagnosis was supported by laboratory data. Both patients were Caucasian individuals of middle age (one male, 47 years old; the other a female aging 36 years) that were considered as previously healthy. Clinically they died from cardiorespiratory insufficiency while being treated in intensive care units. None of them was intubated and blood oxygen levels (SpO2) decreased below 90% only during the agonal phase. Myopericardial changes were visible from a macroscopic point of view, with hemorrhagic and necrotic areas involving pericardium. Fresh hemorrhage and severe hyperemia were both signs of vascular damage and extravasation leading to acute myocardial injuries. Lymphocytic presence was disparate and not constant.
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Open Access December 09, 2022

Socio-Economic and Cultural Barriers that Affect Women’s Participation in Local Level Governance in the Central Region of Ghana

Abstract The study sought to examine the socio-economic and cultural factors that affect women’s participation in local level governance in selected districts in the Central Region of Ghana. The qualitative approach was employed for this study, and an interview guide was used to gather data from 11 women assembly members and two of their husbands, making a total of 13 participants. The participants were [...] Read more.
The study sought to examine the socio-economic and cultural factors that affect women’s participation in local level governance in selected districts in the Central Region of Ghana. The qualitative approach was employed for this study, and an interview guide was used to gather data from 11 women assembly members and two of their husbands, making a total of 13 participants. The participants were sampled using purposive, snowball and convenient sampling techniques. The data was analysed thematically. The study identified lack of self-confidence, limited funds, unsupportive family, abuse and harassment, political affiliations in the Assembly and unsupportive religious organizations as the socio-economic and cultural barriers to women participation in local level governance in Agona West, Gomoa West and Gomoa Central Districts in the Central Region of Ghana. The findings showed that despite the barriers, some of the women were able to surmount such challenges and became successful in the District Assembly elections. The study recommended that special fund should be set up by the government to support Assembly women to perform their roles and responsibilities within their communities regularly. Such funds may help them fulfil their campaign promises, which may encourage them to seek re-election in the District Assemblies. Also, female politicians should mentor potential female politicians. The mentors may support them to build the confidence required to engage in local level politics and to aspire higher positions in political office.
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Open Access November 29, 2022

An Evaluation of Gender Mainstreaming Efforts in a Public University in Ghana: A Case Study of University of Education, Winneba (UEW)

Abstract This paper brings to light efforts of male institutional leaders in the University of Education, Winneba in promoting the gender equality agenda and effects of their efforts in bridging the gender gaps in staff and students’ levels. It sheds further light on involving men in the gender mainstreaming efforts. Both primary and secondary data on gender equality and equity measures were used in this [...] Read more.
This paper brings to light efforts of male institutional leaders in the University of Education, Winneba in promoting the gender equality agenda and effects of their efforts in bridging the gender gaps in staff and students’ levels. It sheds further light on involving men in the gender mainstreaming efforts. Both primary and secondary data on gender equality and equity measures were used in this study. The study found that male Vice-Chancellors have over the years been devoted to promoting gender equality agenda in the University. The effects of their efforts are largely seen in the increase in the number of females that have benefited from the institutional mentorship and scholarship programmes, which has impacted positively on addressing the gender gaps in the University. It is recommended that new strategies be adopted in promoting gender equality agenda. These strategies include revision in gender policies to involve men as agents of change in gender mainstreaming activities; gender training for male staff and students of all levels and categories for effective gender work, offering specific trainings and interactive discussions on gender issues for men as volunteers for gender mainstreaming. The study further suggests among other things, the need to engage the university community in entertaining activities like cycling for the equality agenda to be made more real to men and court their interest to promote men’s involvement in gender work.
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Open Access November 04, 2022

Long Term Outcomes and Survivorship of Bilateral Lower Limb Arthroplasties in Patients with Multiple Epiphyseal Dysplasia

Abstract Background: Multiple epiphyseal dysplasia (MED) a rare form of skeletal dysplasia with early-onset osteoarthritis affecting the hip and knee joints. There is paucity of evidence regarding the long term outcomes of arthroplasty in this patient cohort. This is the first study to describe the outcomes of bilateral arthroplasty of the hip and knee in patients with MED. Methods: A prospective study of patients with MED who underwent bilateral staged total hip arthroplasty (THA) and bilateral simultaneous total knee arthroplasty (TKA) between July 2013 to April 2014. Preoperative and postoperative clinical and radiographic assessment including functional outcomes namely Merle d’aubigne score, Harris hip score (HHS), Knee society score (KSS) and numeric rating scale (NRS) for pain were recorded in prospective database and evaluated. Results: 3 patients (female - 1 / male - 2) with MED who underwent bilateral lower limb arthroplasty of the hip and knee were reviewed periodically with an average followup of 7.31 years. Mean preoperative Merle d'Aubigné score (6.33 ± 0.58), HHS (31.83 ± 5.31) and KSS (28.67 ± 7.97) increased following bilateral lower limb arthroplasty with mean postoperative Merle d'Aubigné score (16.33 ± 0.58), HHS (84.33 ± 5.99) and KSS (86.33 ± 7.09) (P<0.001). Mean NRS decreased from 7.33 ± 0.58 in the preoperative period to 0.67 ± 0.58 at the most recent followup (P [...] Read more.
Background: Multiple epiphyseal dysplasia (MED) a rare form of skeletal dysplasia with early-onset osteoarthritis affecting the hip and knee joints. There is paucity of evidence regarding the long term outcomes of arthroplasty in this patient cohort. This is the first study to describe the outcomes of bilateral arthroplasty of the hip and knee in patients with MED. Methods: A prospective study of patients with MED who underwent bilateral staged total hip arthroplasty (THA) and bilateral simultaneous total knee arthroplasty (TKA) between July 2013 to April 2014. Preoperative and postoperative clinical and radiographic assessment including functional outcomes namely Merle d’aubigne score, Harris hip score (HHS), Knee society score (KSS) and numeric rating scale (NRS) for pain were recorded in prospective database and evaluated. Results: 3 patients (female - 1 / male - 2) with MED who underwent bilateral lower limb arthroplasty of the hip and knee were reviewed periodically with an average followup of 7.31 years. Mean preoperative Merle d'Aubigné score (6.33 ± 0.58), HHS (31.83 ± 5.31) and KSS (28.67 ± 7.97) increased following bilateral lower limb arthroplasty with mean postoperative Merle d'Aubigné score (16.33 ± 0.58), HHS (84.33 ± 5.99) and KSS (86.33 ± 7.09) (P<0.001). Mean NRS decreased from 7.33 ± 0.58 in the preoperative period to 0.67 ± 0.58 at the most recent followup (P<0.001). One patient had heterotrophic ossification following THA. There were no revisions. Conclusions: Bilateral lower limb arthroplasty of the hip and knee is a good treatment option to restore function and mobility in MED patients with advanced degenerative arthritis. Careful preoperative planning, meticulous surgical techniques, patient focussed postoperative rehabilitation with multidisciplinary team approach are vital to ensure good functional outcomes and implant survivorship.
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Case Series
Open Access November 03, 2022

Assessment of Free Sanitary Pad Intervention Programme for Girls’ Education and School Retention in Tolon District in the Northern Region of Ghana

Abstract The purpose of this study was to examine the Free Sanitary Pad Intervention Programme for Girls’ Education and School Retention in Tolon District in the Northern Region of Ghana. Quantitatively, a descriptive cross-sectional research design was adopted for the study. The study population consist of female menstruating school adolescent girls from these five St, Monica’s R/C, Nyankpala D/A, Nizamia [...] Read more.
The purpose of this study was to examine the Free Sanitary Pad Intervention Programme for Girls’ Education and School Retention in Tolon District in the Northern Region of Ghana. Quantitatively, a descriptive cross-sectional research design was adopted for the study. The study population consist of female menstruating school adolescent girls from these five St, Monica’s R/C, Nyankpala D/A, Nizamia E/A, Islamia E/A and Nawaria E/A junior high schools between the ages of 10 to 22 years who were beneficiaries of CAMFED intervention programmes in the Tolon district. A homogeneous purposive sampling technique was used to select the five junior high schools and the one-hundred and fifty (150) adolescent girls in their menstrual cycle stage. The main instrument for data collection was a semi-structured questionnaire. The data entry and analysis were done by using the SPSS version 20 software package. The data was edited, coded and analysed into frequencies, percentages with interpretations. The study concluded that, there were frequent distribution of free sanitary pads among the beneficiaries’ schools. The study also indicated that the education given to the respondents during the distribution of the free sanitary pads led to improved menstrual hygiene management practices. It is recommended that, schools within the Tolon district should put in place the necessary and adequate toiletry and disposal systems to ensure menstrual hygiene among students especially, girls, during that time of the month. It is also recommended that, Government should make it a priority to provide every school with some sanitary products and drugs to cater for the female student taken by surprise with her monthly flow or the pain associated with mensuration not interfering with her academic work.
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Open Access October 05, 2022

An Assessment into Parental Factors that Motivate Female Students to Complete Formal Education

Abstract Qualitatively the study adopted a case study research design to examine the parental factors that motivate female students to complete formal education in Tolon District. The population for this study comprised of all females in the Tolon District who have successfully completed formal education. A purposive sampling technique was used to select ten (10) females who have successfully completed [...] Read more.
Qualitatively the study adopted a case study research design to examine the parental factors that motivate female students to complete formal education in Tolon District. The population for this study comprised of all females in the Tolon District who have successfully completed formal education. A purposive sampling technique was used to select ten (10) females who have successfully completed formal education and are now working in the Tolon District. The main instrument used for data collection was interview. Data were analysed by the use of the Interpretive Method based on the themes arrived at during the data collection. The themes were related to the research question and interpreted on the number of issues raised by respondents. The study revealed that, financial support of parents was vital to enrolment, sustenance and ultimate completion of the education of females. The study also indicated that parents give support in the form of guidance and counseling as well as moral support through encouragement of the Girl-Child played a key role to their successful education. It is recommended that, parents still need more advocacies on the importance of educating the girl child in order to enhance their interest in sending or motivating the girl child in school. It is also recommended that parents should discouraged early marriages to help girls to fully complete their formal education.
Article
Open Access September 08, 2022

Case Fatality Rate and Prognosis of Stroke Hospitalized Patients: A retrospective hospital-based study at the Korle Bu Teaching Hospital

Abstract Introduction: Stroke is associated with high mortality. It is the main neurological cause of mortality and the most important cause of disability worldwide. In the year 2007, Stroke was the third cause of admission at the Korle-Bu Teaching Hospital, and the number one cause of death. Objective: To determine the probability of survival (case-fatality rates) of stroke patients admitted [...] Read more.
Introduction: Stroke is associated with high mortality. It is the main neurological cause of mortality and the most important cause of disability worldwide. In the year 2007, Stroke was the third cause of admission at the Korle-Bu Teaching Hospital, and the number one cause of death. Objective: To determine the probability of survival (case-fatality rates) of stroke patients admitted at the Korle- Bu Teaching Hospital during the period 2007. Method: A Retrospective descriptive study of Surgical/Medical Emergency, SME and the Medical wards admissions and discharges from 1st January 2007 to 31st December, 2007. Results: A total of 250 hospitalized stroke patients were identified, of which 68(27%) were from the SME and 182(72%) from the medical wards. The mean age (SD) was 57.6(14.7) and 52% were males. Case fatality rate was 52% at the SME versus 35% at the Medical wards) whilst the risk of death in males expressed as risk ratio (RR) was 2.1, (95% CI 0.70-5.6) vs. RR=1.3, (95% CI 0.73-2.5) in females and the median survival time was 2days (95% CI 1.5-2.4) versus 7 days (95% CI 6.3-7.6) at the SME and Medical respectively. The type of admission and stroke outcome was significant P=0.01 (95%CI 0.02-0.14). Conclusion: Stroke was associated with high mortality. The risk of dying from stroke was higher at the SME Findings were independent of stroke subtype, stroke onset and any associated co-morbidities.
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Open Access July 13, 2022

Practical Teaching Model in Double Indicator Titration: Influences on Academic Achievement of Chemistry Students

Abstract The purpose of this study was to evaluate a practical model in teaching double indicator titration in chemistry in the senior high schools in Ghana Research design for the study was Action research. The population was made up of chemistry teachers and students. in four senior high schools with two schools located in the Kwaebibirim District and two senior high schools located in the Denkyembuo [...] Read more.
The purpose of this study was to evaluate a practical model in teaching double indicator titration in chemistry in the senior high schools in Ghana Research design for the study was Action research. The population was made up of chemistry teachers and students. in four senior high schools with two schools located in the Kwaebibirim District and two senior high schools located in the Denkyembuo District of the Eastern Region of Ghana. Purposive and simple random sampling techniques were used to select the respondents for the study. The sample comprised of twenty-five (25) chemistry teachers and one hundred and fifty (150) students in the four Senior High schools. The study indicated that Chemistry teachers would improve upon the academic performance of chemistry students in double indicator titration when they use the developed practical teaching model (DEPTEM) more. The main instruments used in this study were classroom observational checklists and questionnaires. Descriptive statistics (frequency, percentage, mean and standard deviation) were used to analyze the data gathered. Coding schemes were developed using Statistical Package for Social Sciences (SPSS) (version 21) to organize the data into meaningful and manageable categories. The study also revealed that the outcome of the post-test indicated that, the DEPTEM impact differently on the academic performance of SHS male and female chemistry students in the Kwaebibirim and Denkyembuo Districts of the Eastern Region. It is recommended that the government and non-governmental organizations should collaborate with the Ministry of Education to sponsor in production of more of the developed practical model (DEPTEM) for teaching chemistry lessons. This in a way would help improve the academic performance of chemistry students in the Kwaebibirim and Denkyembuo Districts of the Eastern Region and the nation at large. It is also recommended that chemistry teachers should consider teaching methods that would equally cater to both male and female chemistry students during chemistry lessons.
Article
Open Access June 28, 2022

A Case Report of Sagittal Sinus Thrombosis and Pulmonary Embolism in an Asymptomatic SARS-CoV-2 Infection

Abstract Background: Vascular thrombotic events such as pulmonary embolisms have been frequently reported in the course of SARS-Cov-2 infection. However, sagittal sinus thrombus is extremely rare, and patients may lack other appealing Covid-19 infection symptoms. Case report: 46-year-old female with past medical history of Hyperlipidemia, Hypertension presented to [...] Read more.
Background: Vascular thrombotic events such as pulmonary embolisms have been frequently reported in the course of SARS-Cov-2 infection. However, sagittal sinus thrombus is extremely rare, and patients may lack other appealing Covid-19 infection symptoms. Case report: 46-year-old female with past medical history of Hyperlipidemia, Hypertension presented to Emergency room with headache, chest pain, vomiting. SARS-CoV-2 IgG Antibodies were reactive. Except for elevated PTT-Lupus Anticoagulant at 50 Sec, Hypercoagulable workup was negative. The MRI venogram findings were consistent with the Dural thrombus of superior sagittal sinus. Patient subsequently developed chest pain, and Computed tomography angiography found pulmonary emboli within segmental branches of the right lower lobe pulmonary artery. Patient was managed in the ICU with Heparin and switched to Coumadin for discharged. Conclusion: The incidence of Cerebral Venous Sinus thrombus (CVST) among Covid-19 patients is inferior to 0.02%. And most of the patients lack typical Covid-19 presentations such as pneumonia. The lack of symptoms may promote the insidious course of pre-thrombotic events that lead to CVST. However more Retrospective studies are necessary to established consistent odd ratios. Due to the higher mortality associated with CVST and the ongoing of Covid-19 pandemic, we recommend a higher level of clinical suspicion.
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Case Report
Open Access June 05, 2022

The Feminine State of Ethnicity: Changing Ethnic Representations in Doctor Who

Abstract This study aims to consider how science fiction television series Doctor Who (Sydney Newman, 1963-1989, 2005) has undergone changes in representations of ethnicity since 2005. The Doctor, who is a representation of immigrants from the very beginning, was embodied in white, heterosexual men until the 11th season. Last season is the first season since 1963 when a woman is the Doctor. In addition, this season, the Doctor's three companions are Ryan who is a black man, Yaz who is a Pakistani-British woman and Graham who is a middle-aged white man mourning his wife Grace who was black. In this study, it is aimed to analyze the features that make this season different from the others in terms of representations of ethnicity by using visual data analysis techniques and Smith's national identity theory. In this study, it has been proposed that the previous episodes of the Doctor Who [...] Read more.
This study aims to consider how science fiction television series Doctor Who (Sydney Newman, 1963-1989, 2005) has undergone changes in representations of ethnicity since 2005. The Doctor, who is a representation of immigrants from the very beginning, was embodied in white, heterosexual men until the 11th season. Last season is the first season since 1963 when a woman is the Doctor. In addition, this season, the Doctor's three companions are Ryan who is a black man, Yaz who is a Pakistani-British woman and Graham who is a middle-aged white man mourning his wife Grace who was black. In this study, it is aimed to analyze the features that make this season different from the others in terms of representations of ethnicity by using visual data analysis techniques and Smith's national identity theory. In this study, it has been proposed that the previous episodes of the Doctor Who television series were problematic in case of representations of ethnicity, and the ongoing representations of ethnicity are changing under the leadership of the female Doctor and his ethnically diverse companions during the era of Chris Chibnall and the episodes are examined using this framework.
Article
Open Access May 26, 2022

Women and Places; Female Street Vendors, Territorial Identity and Placemaking

Abstract Street vending is a vital part of global urban life and not a local phenomenon. It can be found in various countries and forms; stationary and mobile. In Egypt, street vendors’ activities are considered illegal, an image of backwardness, blocking investors and tourism. This study aims at monitoring and investigates the female street vendors' role in placemaking in Heliopolis, Cairo. Challenging [...] Read more.
Street vending is a vital part of global urban life and not a local phenomenon. It can be found in various countries and forms; stationary and mobile. In Egypt, street vendors’ activities are considered illegal, an image of backwardness, blocking investors and tourism. This study aims at monitoring and investigates the female street vendors' role in placemaking in Heliopolis, Cairo. Challenging the authoritarian illegality aspect, literature review, observational walks, and spontaneous interviews are adopted in obtaining data and evaluating the female street vendors’ role in constructing a sense of place and identity. Female street vendors' expression, displaying arrangement, socio-cultural identities and chancy events create livable public places, territorial identities and a sense of place.
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Open Access May 22, 2022

Prevalence and predictors of physical activity among female high school students in The Gambia: an institutional-based cross-sectional study

Abstract Background: Everyone, irrespective of age, sex, colour, ethnicity, or present overall fitness level, can benefit from regular exercise. To improve one's health, one must engage in regular physical activity. People with underlying illnesses like long-term impairment can benefit from regular physical activity at the individual level, especially young women. Thus, the current study aimed to [...] Read more.
Background: Everyone, irrespective of age, sex, colour, ethnicity, or present overall fitness level, can benefit from regular exercise. To improve one's health, one must engage in regular physical activity. People with underlying illnesses like long-term impairment can benefit from regular physical activity at the individual level, especially young women. Thus, the current study aimed to assess the prevalence and determinants of physical activity among female school-aged adolescents in the West Coast Region of The Gambia. Methods: The present study used an institutional-based cross-sectional analytical study to collect quantitative data from 384 female high school students in The Gambia. The study used a content-validated, pretested structured questionnaire that consisted of both open and closed-ended questions on physical activity. The data were processed and analyzed using IBM SPSS version 26.0. Descriptive statistics and Chi-square and/or Fisher exact test were used with a p-value <0.15 for inclusion in the logistic regression model. Adjusted odds ratios (aORs) and 95% confidence intervals were calculated, while p-value <0.05 was considered for statistical significance. Results: The proportion of female students involved in physical activity was 37.5%. The mean age of students was 18.8 years with a standard deviation of 1.7 years. Factors such as female students between 17 – 20 years (aOR:3.05, 95% C.I. (1.807 – 5.138)), father never been to school (aOR: 2.82, 95% C.I. (1.495 – 5.334)), primary education (aOR: 2.15, 95% C.I. (1.027 – 4.493)), upper basic school (aOR: 2.31, 95% C.I. (1.055 – 5.074)) and science major students (aOR: 2.21, 95% C.I. (1.203 – 4.047)) had increased odds of involving in PA. Furthermore, students who knew that exercise would strengthen bones (aOR: 2.62, 95% C.I (1.444 – 4.739)), do a planned brisk walking (aOR: 19.16, 95% C.I. (6.698 – 54.811)), basketball/football (aOR: 29.76, 95% C.I. (10.004 – 88.512)) and skipping with rope (aOR: 29.15, 95% C.I. (9.726 – 87.333)) had increased odds to involved in PA after controlling for confounders. Other factors such as students whose mother never been to school (aOR: 0.31, 95% C.I. (0.140 – 0.674)), primary level (aOR: 0.25, 95% C.I. (0.123 – 0.518)), senior secondary level (aOR: 0.42, 95% C.I. (0.189 – 0.935)), nuclear family (aOR: 0.23, 95% C.I. (0.119 – 0.458)) and extended family (aOR: 0.45, 95% C.I. (0.225 – 0.915)) had reduced odds of involving in PA. Conclusion: There is low physical activity among female adolescents in schools. For this, it is imperative that suitable interventions be implemented to raise the level of physical activity among secondary school students. A future intervention for school-aged adolescents could benefit from these findings.
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Open Access April 23, 2022

Variables Associated with Low Female Participation in College of Education Sports in Central, Western and Western North Regions of Ghana

Abstract The purpose of the study was to examine factors associated with low female participation in colleges of education sports. The population of the study was made up of female colleges of education athletes from Central, Western and Western North Regions of Ghana. Purposive and simple random techniques were used to the colleges of education and the respondents for the study. All the all the six [...] Read more.
The purpose of the study was to examine factors associated with low female participation in colleges of education sports. The population of the study was made up of female colleges of education athletes from Central, Western and Western North Regions of Ghana. Purposive and simple random techniques were used to the colleges of education and the respondents for the study. All the all the six colleges of education were purposively sampled and sampling technique was used to select the one hundred and eighty (180) participants who participate in the College of Education Sports Association (CoESA) games and in the Central, Western and Western North Regions of Ghana were used for the study. The main instrument for the study was a self-structured questionnaire (r= 0.92) containing items based on a five-point Likert scale was used for data collection. The data was analyzed using frequencies, percentages and Chi-square test to determine the relationship among the factors. The study revealed that there is the need for college authorities and female coaches in the colleges of education to take care of female athletes and make adequate provision for more modern sports facilities and equipment to sustain their interest in sports participation. The study recommended that, that the coaches should be mindful of their approach to prospective sportswomen. It is also recommended that, various colleges of education should make a concerted effort to organize programmes and seminars regularly to educate females in the colleges on the career benefits of sports participation and iron out their misconceptions.
Article
Open Access April 18, 2022

Factors that Influence the Academic Motivation of Female Students

Abstract The study used qualitative research approach and a case study research design to explore the factors that motivate females to complete formal education in Tolon District. The population for this study comprised all females in the Tolon District who have successfully completed formal education. A purposive sampling technique was to select ten (10) females who have successfully completed formal [...] Read more.
The study used qualitative research approach and a case study research design to explore the factors that motivate females to complete formal education in Tolon District. The population for this study comprised all females in the Tolon District who have successfully completed formal education. A purposive sampling technique was to select ten (10) females who have successfully completed formal education and are now working in the Tolon District. The main instrument used for data collection was interview guide. Data were analysed by the use of the Interpretive Method based on the themes arrived at in the data collection. The themes were related to the research questions and interpreted on the number of issues raised by participants. The study concluded that the Girl–Child requires a conducive learning environment free from limitations to successfully acquire formal education. The presence of an impressive teacher-student relationship in schools contributes immensely to the academic accomplishment of the academic goals of the female student. The study also concluded that the female students need self determination to rise above the socio-cultural limitations encountered in formal education. They obviously have to work hard and persevere enough to achieve their desired academic accomplishment. It is recommended that teachers should be encouraged as part of their teaching responsibility to give equal opportunity to both boys and girls, in answering their questions during classes. Thus, the Girl–Child deserves extra attention to ensure their participation and fair inclusion in curricular and other extra-curricular activities whiles in school. It is also recommended that teachers should sensitize and advise the female students to eschew the habit of associating with men, during the early stage of their life.
Article
Open Access February 22, 2022

Attitude towards the Teaching Profession: The Secondary School Teachers’ Outlook

Abstract Investigated in this study is the attitude of secondary school teachers towards the teaching profession. Survey design was adopted for the study and three research questions guided the study. The sample of the study comprises of all the 55 secondary school teachers of Senior Secondary 2 (SS2) in urban and rural schools, in Awka South Local Government Area, Anambra State. The instrument for data [...] Read more.
Investigated in this study is the attitude of secondary school teachers towards the teaching profession. Survey design was adopted for the study and three research questions guided the study. The sample of the study comprises of all the 55 secondary school teachers of Senior Secondary 2 (SS2) in urban and rural schools, in Awka South Local Government Area, Anambra State. The instrument for data collection was a 20 item questionnaire developed by the researchers. The data collected was analyzed by computing mean and standard deviation. The findings of the study revealed that the majority of the secondary school teachers possessed positive attitude towards the teaching profession. It was also found that the female secondary school teachers had more positive attitude towards the profession than the male secondary school teachers. Furthermore, the secondary school teachers in urban areas had higher positive attitude than the secondary school teachers in rural areas. Based on the findings of the study, it was recommended that both the government and teacher organization should see to the training, retraining and motivation of secondary school teachers. If they are well-trained and motivated, they will be more committed and learning will be enhanced.
Article
Open Access December 13, 2021

Idiopathic Retroperitoneal Fibrosis: A Case of Women 75-years Old Without Ureteral Involvement

Abstract A 75-year-old female is referred for evaluation of a progressive leg swelling. Angiological and MRI evaluation show the presence of inflammatory tissue surrounding the aorta and the left iliac vessels, causing significant stenosis. Upon suspicion of retroperitoneal fibrosis, we actively seek for secondary causes such as malignancies, autoimmune diseases and infections, as well as IgG4-related [...] Read more.
A 75-year-old female is referred for evaluation of a progressive leg swelling. Angiological and MRI evaluation show the presence of inflammatory tissue surrounding the aorta and the left iliac vessels, causing significant stenosis. Upon suspicion of retroperitoneal fibrosis, we actively seek for secondary causes such as malignancies, autoimmune diseases and infections, as well as IgG4-related disease. All investigations result negative and we make the diagnosis of idiopathic retroperitoneal fibrosis. Steroid therapy was started and we observed a rapid amelioration of symptoms and radiological disappearance of the inflammatory tissue around the aorta.
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Open Access November 29, 2021

Mucormycosis and Candida Infections in Patients of COVID-19 Pneumonia: A Systematic Review

Abstract Introduction: The city of Wuhan in China reported the first case of coronavirus, termed as SARS-CoV-2, in December 2019. To date, 187,827,660 cases have been reported to the WHO (3). With current research focusing on potential therapeutic agents for the coronavirus disease and vaccines, there remain major gaps in our understanding of the pathophysiology and clinical course of this viral [...] Read more.
Introduction: The city of Wuhan in China reported the first case of coronavirus, termed as SARS-CoV-2, in December 2019. To date, 187,827,660 cases have been reported to the WHO (3). With current research focusing on potential therapeutic agents for the coronavirus disease and vaccines, there remain major gaps in our understanding of the pathophysiology and clinical course of this viral pneumonia. Secondary infections are one of them. In this systematic review, we analyze the outcomes of two fungal infections in patients of COVID-19, viz. Mucormycosis and candida. Methodology: A systematic review has been done on secondary infections with mucor and candida fungi in patients of COVID-19. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used. Twenty-three studies were included in the final analysis. Our review included studies from various countries across the globe. The risk of bias was analyzed using the NIH Quality Assessment Tool for Case Series Studies. This study did not require ethical approval as data was obtained from already available databases, and patients were not directly involved. Results: A total of 23 articles were included in the final review and the total number of patients included was 79 Male: female ratio was calculated to be 1.6 and the average age of patients was 52 years (ranging from 24-86 years). Various types of comorbidities were seen in the included patients, the most common being diabetes mellitus. Among the 18 patients in the cohort of mucormycosis, 7 patients died and four studies did not report patient outcomes. Among the 61 patients, 13 patients died and one patient was still ventilated at the time of publication. Conclusion: Secondary infections after COVID-19 are a cause of major concerns. Further studies and case reports are needed to better understand the various other types of secondary infections and also to formulate strategies to prevent these.
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Systematic Review
Open Access November 22, 2021

COVID-19 and Legionella Co-Infection

Abstract Introduction: Concurrent infections or co-infections in patients diagnosed with Coronavirus Disease-19 (COVID-19) are not uncommon and predict a pejorative prognosis. A co-infection accounts for 1 out of every 5 cases of COVID-19 and increases the likelihood of adverse health outcomes such as mechanical ventilations, ICU admissions, and death. Specifically, Legionella spp. [...] Read more.
Introduction: Concurrent infections or co-infections in patients diagnosed with Coronavirus Disease-19 (COVID-19) are not uncommon and predict a pejorative prognosis. A co-infection accounts for 1 out of every 5 cases of COVID-19 and increases the likelihood of adverse health outcomes such as mechanical ventilations, ICU admissions, and death. Specifically, Legionella spp. co-infection presents additional challenges in COVID-19 patients because of its rarity, similar clinical presentation to SARS-CoV-2, and poorer outcomes without prompt treatment. Cases Presentation: Case 1. A 62-year-old female presented with a 3-day history of subjective fever and worsening shortness of breath. Room air saturation (saO2) was 70% and improved to 100% on noninvasive positive- pressure ventilation (NIPPV). Lung auscultation revealed rales BL. Chest X –Ray (CXR) showed patchy airspace opacities bilaterally (BL), SARS-CoV-2 PCR and urine legionella antigen tests were positive. The diagnosis of hypoxic respiratory failure secondary to COVID-19 and Legionella pneumonia was made. Patient was admitted to intensive care unit (ICU) and managed with decadron, remdesivir, one unit of convalescent plasma for COVID-19 and Azithromycin for Legionella. Patient subsequently developed acute respiratory distress syndrome (ARDS). ARDS protocol was initiated. 13 days after, the patient was compassionately extubated. Case 2. A 41-year-old male presented with 5-day history of fever, worsening shortness of breath, cough and diarrhea. Patient admitted history of ethanol abuse. SaO2 was 88% and improved on oxygen canula. Lung auscultation revealed rhonchi BL. CXR showed extensive left lung consolidation. Urine test for legionella antigen was positive. COVID-19 PCR was negative, but SARS-CoV-2 IgG was reactive. The diagnosis of Legionnaire disease was made. Despite initial treatment with Azithromycin, patient's hypoxia continued to worsen requiring NIPPV, and subsequently mechanical ventilation in the ICU. The adjunction of empiric treatment for COVID-19 with convalescent plasma, remdesivir and steroids improved both clinicals and laboratory findings. Discussion: The cases illustrated the practical challenges of managing COVID-19 and legionella co- infection. Legionella spp and SARS-CoV-2 overlapping incubation periods and similar clinical presentations and complications. In the absence of diagnosis and treatment, legionella pneumonia has an intrinsic mortality rate of up to 80%. As some COVID-19 mitigation strategies, such as the closure of businesses, have enhanced the conditions for Legionella spp proliferation, the incidence of Co-infection with COVID-19 may increase. We recommend clinicians to have high-indexed suspicion of COVID-19 and Legionella co-infection in order to obtain complete work up at patient’s initial presentation.
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Open Access August 14, 2021

Genes of Gall 200C and Nematode 200C May Develop Biomedical Vaccines Against Plants and COVID-19 Diseases: Advanced Medical Science Technology Agriculture Health Issues

Abstract The outbreaks and quick spread of severe-acute-respiratory-syndrome-coronavirus 2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), have badly affected the whole world due to continuous emergence-and-transmission of the latest-new viral-genomes forming new-variants revealing patterns of the SARS-CoV-2 outbreak-and-global-pandemic with badly affecting advanced-medical-science-technology-communication-agriculture-agronomy-plant-breeding-horticulture, health-environment-socio-economy, and different-issues. India's emphasis on okra, the ‘Nature's-Gift to Human-Disease-Free-Healthy-Life’ and the most ‘Economically-Important-Number-One-Consumption Vegetable-Crops’ is destroyed by various-diseases causing pathogens like the root-knot (RK)-diseases caused by the nematodes, Meloidogyne incognita [...] Read more.
The outbreaks and quick spread of severe-acute-respiratory-syndrome-coronavirus 2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), have badly affected the whole world due to continuous emergence-and-transmission of the latest-new viral-genomes forming new-variants revealing patterns of the SARS-CoV-2 outbreak-and-global-pandemic with badly affecting advanced-medical-science-technology-communication-agriculture-agronomy-plant-breeding-horticulture, health-environment-socio-economy, and different-issues. India's emphasis on okra, the ‘Nature's-Gift to Human-Disease-Free-Healthy-Life’ and the most ‘Economically-Important-Number-One-Consumption Vegetable-Crops’ is destroyed by various-diseases causing pathogens like the root-knot (RK)-diseases caused by the nematodes, Meloidogyne incognita (Kofoid & White) Chitwood, and easily checked by many chemical-pesticides. But it causes different carcinogenic effects on the environment and our life. So it is an urgent need to develop potential biomedicines. The pretreatments with ultra-high-diluted-biomedicines (UHDBMs) Gall 200C and Nematode 200C, prepared from okra-root-galls (ORG) and nematode-females (NF) respectively, applied by foliar spray@ 20 ml/plant, are highly effective against the root-knot-disease of okra, Abelmoschus esculentus (L.) Moench Cv. Ankur-40, with the increasing growth of plants and fruits-production. The UHDBMs-Gall 200C is more effective than the Nematode 200C. Both the pretreatments-UHDBMs are responsible for induce-systemic-acquired-defense-response of the pretreated-plants through the expression of pathogenesis-related (PR)-proteins-genes (22-14 numbers), which are more or less similar-molecular-range (295kD-11kD) of many coronavirus, which will be responsible for preventing-RK and COVID-19 like virus-diseases by inducing-defense-resistance or increasing innate-immunity respectively, and advanced in medical-science, technology, communication, agriculture, agronomy, plant breeding, horticulture, health, environment, socio-economy, and different application-issues with pollution-free globe, developing new-preventive typical-biomedical vaccines or treatments methods or drug development and research against the ‘21st-Century Global Pandemic COVID-19 like Any Viral Diseases’ which lead to optimal contributions to the field of policymaking drug and vaccine development emphasizing new or important aspects of the study, and synthetic production of UHDBMs will be more practical implications, and social implications in the future research. And the farmers and the world would be benefitted most; by collecting and uprooting gall-roots after harvesting for cost-effective bio-controlling plant-diseases, and profit from shelling-and-buying of whole plants, fruits, and gall-roots also, and helps for the benefit of global health by developing the most cost-effective, personalized, non-toxic, easily-preparable, easily-maintainable, easily-available and suppliable, vaccines or treatments methods from their own product.
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Open Access July 27, 2021

An Adolescent Case of Influenza-Related Pulmonary Atelectasis

Abstract A 16-year-old female patient had influenza and was treated by inhalation of an anti-influenza agent. However, two days later, she showed slight dyspnea, and massive atelectasis of the left lung with hypoxia was found. She was admitted to our hospital (Day 0) and started on antibiotics and steroids, but the atelectasis was worsend on Day 3. Therefore, bronchoscopy was performed on Day 5. After the [...] Read more.
A 16-year-old female patient had influenza and was treated by inhalation of an anti-influenza agent. However, two days later, she showed slight dyspnea, and massive atelectasis of the left lung with hypoxia was found. She was admitted to our hospital (Day 0) and started on antibiotics and steroids, but the atelectasis was worsend on Day 3. Therefore, bronchoscopy was performed on Day 5. After the pus in the left bronchus was removed, the atelectasis was significantly improved. Atelectasis after influenza may be a rare, but critical complication, and bronchoscopy should be considered to release the obstructive lesions.
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