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Open Access September 09, 2025

Biopsy-Negative Giant Cell Arteritis Presenting as Stroke Mimic with Vision Loss and Complex Vascular Disease

Mohamed M. Khamis, Daniel Goering

Global Journal of Medical Case Reports 2025, 5(1), 29-35. DOI: 10.31586/gjmcr.2025.6177

Abstract A man in his 60s with multiple vascular comorbidities presented with sudden, painless vision loss in one eye. Although he had a high risk for atherosclerotic events, initial evaluation for stroke was negative for acute ischemia, but found to have markedly elevated inflammatory markers. Accordingly, giant cell arteritis was investigated and Ophthalmologic findings and fulfillment of the 2022 [...] Read more.

A man in his 60s with multiple vascular comorbidities presented with sudden, painless vision loss in one eye. Although he had a high risk for atherosclerotic events, initial evaluation for stroke was negative for acute ischemia, but found to have markedly elevated inflammatory markers. Accordingly, giant cell arteritis was investigated and Ophthalmologic findings and fulfillment of the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria supported the diagnosis of giant cell arteritis, despite a negative temporal artery biopsy. Management included high-dose glucocorticoids and delayed tocilizumab initiation due to the need for multiple vascular surgeries. Vision loss was irreversible, but systemic symptoms resolved and vascular interventions were successful. This case highlights the diagnostic and management complexities of biopsy-negative giant cell arteritis in patients with severe atherosclerotic vascular disease, emphasizing the importance of clinical judgment and established classification criteria when imaging and biopsy results are inconclusive.

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Case Report

Open Access April 29, 2024

Predictors of Patient Outcomes Associated with Transfer Status to Definitive Care Hospitals: A Study of Admitted Road Traffic Injured Patients in Two Major Trauma Hospitals in The Gambia

Edrisa Sanyang, Paul Bass, Bakary Ndow, Abubacarr Jagne, Erin M. Reynolds

Current Research in Public Health 2024, 4(1), 13-25. DOI: 10.31586/crph.2024.820

Abstract The Gambia uses the Primary Health Care model with no trauma response system. Trauma patients are transferred through multiple levels of health care facilities before definitive care hospitals. This study was conducted to identify predictors of injury factors associated with transfer. In this study, we examined characteristics of transferred patients compared to those directly admitted in [...] Read more.

The Gambia uses the Primary Health Care model with no trauma response system. Trauma patients are transferred through multiple levels of health care facilities before definitive care hospitals. This study was conducted to identify predictors of injury factors associated with transfer. In this study, we examined characteristics of transferred patients compared to those directly admitted in definitive care hospitals. The study was conducted in two major trauma hospitals in The Gambia. 251 road traffic injury (RTI) patients were either transferred (84%) from lower-level health centers or directly admitted (16%) to one of the study hospitals. Transferred patients were more likely to have been pedestrian/bicyclists (aOR = 1.81; 95% CI = 0.86 – 3.80). Administration of antibiotics was significantly associated with direct admit than transferred patients (aOR = 6.84; 95% CI = 2.38 – 19.68). Transferred patients were more likely to receive intravenous fluid compared to direct admits (aOR = 0.03; 95% CI = 0.01 – 0.08). The study results have implications for policies and planning in the healthcare setting in The Gambia and other LMICs with similar settings. Based on the findings of this study, it is essential that hospital management teams adapt to increasing reliance of RTI patients on lower-level healthcare facilities. The study results suggest increased burden on lower-level health care facilities. Efforts and resources should focus more on supporting lower-level facilities.

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Article

Open Access February 27, 2024

Clinical characteristics of patients with multiple respiratory viruses during the COVID-19 pandemic period

Masafumi Seki, Haruki Naruse, Yuto Suga, Sachi Tanaka, Sachie Koyama, Noriyuki Watanabe, Kotaro Mitsutake

World Journal of Medical Microbiology 2024, 3(1), 1-3. DOI: 10.31586/wjmm.2024.889

Abstract Respiratory virus co-infections have been suggested to happen frequently and exacerbate patients’ conditions, but little is known about the detailed rates and the combinations of viruses during the COVID-19 pandemic period. A total of 255 symptomatic patients who underwent multiplex PCR tests were analyzed, and it was found that 6 (6/255=2.4%) patients were infected with multiple viruses. The [...] Read more.

Respiratory virus co-infections have been suggested to happen frequently and exacerbate patients’ conditions, but little is known about the detailed rates and the combinations of viruses during the COVID-19 pandemic period. A total of 255 symptomatic patients who underwent multiplex PCR tests were analyzed, and it was found that 6 (6/255=2.4%) patients were infected with multiple viruses. The patients ranged in age from 1 to 38 years, and one female patient was pregnant. Of the 6 patients, 4 had fever, and 5 had human rhinovirus/enterovirus and another virus. These data suggested that the rate of respiratory virus co-infection was low, and the combination of SAS-CoV-2 and other viruses was rare even during the COVID-19 pandemic.

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Commentary

Open Access January 02, 2024

Constructability and Rigor of Angles Multiples of 3 in Euclidean Geometry

Alex Mwololo Kimuya

Journal of Mathematics Letters 2024, 2(1), 1-27. DOI: 10.31586/jml.2024.841

Abstract This paper investigates the constructability of angles multiples of 3 within the framework of Euclidean geometry. It makes a significant contribution by presenting the first geometric construction for all such angles, offering a rigorous solution to a longstanding geometric problem. The paper reaffirms the efficacy of Euclidean geometry in providing precise constructions and robust proofs for [...] Read more.

This paper investigates the constructability of angles multiples of 3 within the framework of Euclidean geometry. It makes a significant contribution by presenting the first geometric construction for all such angles, offering a rigorous solution to a longstanding geometric problem. The paper reaffirms the efficacy of Euclidean geometry in providing precise constructions and robust proofs for these angles, demonstrating the enduring strength of Euclidean principles from classical to modern times. The presented workflow goes beyond Euclidean geometry to examine non-Euclidean methods, particularly analytical approaches, revealing misconceptions that compromise the genetic and geometric rigor of Euclidean principles. The paper exposes incongruities when algebraic proofs related to angle constructability are applied to the Euclidean system, emphasizing the misalignment of fundamental geometric concepts. A notable result in the paper is the construction of a angle, introducing the “ angle chord” as a novel geometric property. This property challenges assumptions made by non-Euclidean methods and highlights the nuanced geometric properties crucial for rigorous constructions. The paper refutes the fallacy of relying solely on algebra for solutions to angles multiples of , emphasizing the necessity of embracing Euclidean geometry for geometric discoveries. The paper underscores the merits and resilience of Euclidean geometry, showcasing its independence and depth across historical and modern perspectives. The newly presented geometric construction not only resolves a longstanding question but also emphasizes the intrinsic strength and uniqueness of Euclidean principles in contrast to alternative methodologies.

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Article

Open Access December 13, 2023

Is a Mexico-China Competition Emerging in US Supply Chains? A Comparative Perspective

Shuo Shi, Hanzhen Ouyang

Universal Journal of Finance and Economics 2023, 3(1), 19-31. DOI: 10.31586/ujfe.2023.821

Abstract With the current sources of US supply chains being more diversified than before, China’s share in US goods imports is declining while Mexico becomes the largest exporter to the US market in 2023. However, can Mexico use this trade diversion to successfully outweigh China in US supply chains? This paper thus investigates whether the Mexico manufacturing sector is competitive enough to completely [...] Read more.

With the current sources of US supply chains being more diversified than before, China’s share in US goods imports is declining while Mexico becomes the largest exporter to the US market in 2023. However, can Mexico use this trade diversion to successfully outweigh China in US supply chains? This paper thus investigates whether the Mexico manufacturing sector is competitive enough to completely replace its Chinese counterparts and rise to a strategically vital supplier for the US economy. Based on multiple empirical evidence, we find that although US supply chain sources are shifting from China to Mexico, the major part of the value added of Mexican exports to the US market is generated in China. Moreover, our evidence shows that Mexico’s exports to the US concentrate on low-skill sectors, while China’s mainly consists of high-skill goods. Further discussion shows that the current US trade shift is highly likely due to China’s FDI inflows to Mexico’s traditionally strong export sector, motor vehicles. However, this shift is not significant enough for Mexico to become a capable substitute for China in the US supply chains. We conclude that the "trade diversion" strategy alone cannot support Mexico’s role in reducing the US supply chain dependence on China. Therefore, the US should better consider how to establish a sustainable trade framework that fosters stable cooperation with China.

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Brief Report

Open Access October 16, 2023

Clinical Characteristics and Imaging Findings of Adult COVID-19 and Influenza-related Pulmonary Complications due to Methicillin-susceptible Staphylococcus aureus

Masafumi Seki, Daishi Shimada

Global Journal of Epidemiology and Infectious Disease 2023, 3(1), 1-6. DOI: 10.31586/gjeidd.2023.798

Abstract The pulmonary characteristics of Staphylococcus aureus (S. aureus) co-infection with respiratory viruses, such as SARS-CoV-2 and influenza virus, are still unclear. Case series: Two patients with methicillin-susceptible S. aureus [...] Read more.

The pulmonary characteristics of Staphylococcus aureus (S. aureus) co-infection with respiratory viruses, such as SARS-CoV-2 and influenza virus, are still unclear. Case series: Two patients with methicillin-susceptible S. aureus (MSSA) infection in the lungs co-infected with either SARS-CoV-2 or influenza virus are reported. Case 1 was a 66-year-old woman who was admitted with SARS-CoV-2 infection. Her chest X-ray and computed tomography (CT) showed multiple cavity formations with infiltration shadows, and MSSA was detected from her sputum and blood, suggesting COVID-19-related bacterial pneumonia and pulmonary embolism. No catheters had been used, but she had skin eruptions and a history of SARS-CoV-2 vaccination. Ampicillin/sulbactam (ABPC/SBT) was administered, and she finally improved. Case 2 was an 87-year-old man with a history of atopic dermatitis who was admitted with moderate pneumonia, and influenza virus co-infection was found. He showed multiple cavitary shadows, and MSSA was isolated from both his sputum and blood. He was diagnosed with influenza-related bacterial pulmonary embolism. No catheters had been used, but he had a history of influenza vaccination. He was also treated by ABPC/SBT and finally improved. Conclusions: These cases suggest that MSSA showed affinity to the lungs when co-infected with either SARS-CoV-2 or influenza virus, and it presented as septic emboli without catheter use. We should consider MSSA infection when patients have SARS-CoV-2 or influenza virus co-infection, and multiple cavity formation and skin disorders are seen, even though they were vaccinated and no catheters were used.

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Case Series

Open Access September 19, 2023

Lonely No More: Investigating the Connection between Family Health, Social Support, and Well-being in Chinese “Empty Nest Youth”

Yan-yan Wang

Current Research in Public Health 2023, 3(2), 90-104. DOI: 10.31586/crph.2023.771

Abstract Background: The phenomenon of "empty nest youth" is becoming increasingly ubiquitous, capturing the attention of society at large. However, few studies have been conducted in recent years on this group, especially focusing on their family and mental health. As such, this study investigates the correlation between family health and well-being among "empty nest youth," as well as the function of social support and loneliness in this relationship. Methods: A cross-sectional survey was conducted from June to August 2022 across 32 provinces, municipalities, and autonomous regions in China, utilizing a multi-stage sampling technique. And we screened individuals who were unmarried, living alone, and between 22-44 years old, resulting in a valid sample size of 908 cases; multiple regression analysis, mediation effect testing, and moderation effect testing are used to examine research hypotheses. Results: The regression analysis results show that family health not only has a direct impact on well-being (β = 0.36, p < 0.001) but also indirectly affects well-being through social support [β = 0.23, 95% CI: 0.19 0.28]. Additionally, the loneliness moderates the predictive impact of not only family health on social support (β = -0.13, p < 0.001) but also social support on well-being (β = -0.06, p [...] Read more.

Background: The phenomenon of "empty nest youth" is becoming increasingly ubiquitous, capturing the attention of society at large. However, few studies have been conducted in recent years on this group, especially focusing on their family and mental health. As such, this study investigates the correlation between family health and well-being among "empty nest youth," as well as the function of social support and loneliness in this relationship. Methods: A cross-sectional survey was conducted from June to August 2022 across 32 provinces, municipalities, and autonomous regions in China, utilizing a multi-stage sampling technique. And we screened individuals who were unmarried, living alone, and between 22-44 years old, resulting in a valid sample size of 908 cases; multiple regression analysis, mediation effect testing, and moderation effect testing are used to examine research hypotheses. Results: The regression analysis results show that family health not only has a direct impact on well-being (β = 0.36, p < 0.001) but also indirectly affects well-being through social support [β = 0.23, 95% CI: 0.19 0.28]. Additionally, the loneliness moderates the predictive impact of not only family health on social support (β = -0.13, p < 0.001) but also social support on well-being (β = -0.06, p < 0.001). Conclusions: These findings underscore the significance of directing policymakers and healthcare professionals towards the "empty nest youth's" familial and social support systems. It underscores the need for the development of policies aimed at addressing their emotional and material requirements by leveraging these familial and social networks. This approach ultimately contributes to the enhancement of their overall psychological well-being, promoting a more coherent and logical pathway for intervention and support.

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Article

Open Access April 27, 2023

Evaluation of the Critical risk factors in PPP - procured Mass Housing Projects in Abuja Nigeria - A fuzzy synthetic evaluation (FSE) approach

Arijeloye Bamidele Temitope, Oke Ayodeji Emmanuel, Aje Isaac Olaniyi

World Journal of Civil Engineering and Architecture 2023, 2(1), 58-85. DOI: 10.31586/wjcea.2023.605

Abstract The study accessed the critical risk factors in public-private partnership (PPP)-procured mass housing project (MHP) delivery in Nigeria. The research design adopts a quantitative approach, using well-structured questionnaires distributed to stakeholders involved in PPP-MHPs i.e. consultants, in-house professionals, contractors, and the organized private sector (OPS) registered with PPP [...] Read more.

The study accessed the critical risk factors in public-private partnership (PPP)-procured mass housing project (MHP) delivery in Nigeria. The research design adopts a quantitative approach, using well-structured questionnaires distributed to stakeholders involved in PPP-MHPs i.e. consultants, in-house professionals, contractors, and the organized private sector (OPS) registered with PPP departments in the Federal Capital Territory Development Authority (FCDA) Abuja, Nigeria. The instrument relates to the background information of respondents and the risk peculiar to PPP-MHP. Sixty-three (63) risk factors were submitted for the respondents to rank using Mean Item score (MIS) for risk occurrence and its severity, while risk significance index (RI) was used to determine the risk impact. Fuzzy Synthetic Evaluation (FSE) method was subsequently applied to determine the risk criticality groups and the overall risk level in the sector. The fuzzy set theory deals with ambiguous, subjective and imprecise judgments peculiar to decision making in construction project risk assessment. It aims to provide a synthetic evaluation of an object relative to a fuzzy decision environment with multiple criteria that requires qualitative linguistic terms. The findings show that thirty-one (31) risk factors were critical in the sector while financial and micro-economic risk group is contributing most significantly to the overall risk level in PPP-MHPs in Nigeria. The top 10 risk factors in the sector include availability of finance, high finance cost, the unstable value of the local currency, lack of creditworthiness, influential economic events (boom/recession), high bidding cost, poor financial market, financial attraction to project investors, interest rate volatility, inflation rate volatility, corruption and lack of respect for the law, non-involvement of the host community and poor execution of housing policies. The implication for practice is that having known the risk group contributing most significantly to the overall risk level in PPP-MHPs, adequate financial and budgetary allocation should be made available before embarking on such venture so as to sustain the scheme in the country. The study is one of the recent researches conducted on housing, since the procurement option is novel in the sector. The study is of immense value to PPP actors in providing necessary information required to formulate risk response methods in minimize the identified risk impact sector.

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Article

Open Access March 02, 2023

Traumatic Pneumothorax Secondary to Acupuncture Procedure: A Case Report

Alexander Lopez Villarreal, Pablo-Andres Peréz Giraldo, Alejandro Cardozo, Manuel-Alejandro Garcia Pareja

Global Journal of Medical Case Reports 2023, 3(1), 1-4. DOI: 10.31586/gjmcr.2023.633

Abstract Acupuncture is an alternative medicine, actually it has had a greater acceptance in our continent being use for multiple therapeutic purposes. Although it is a minimally invasive procedure it is not exempt from complications, most common minor complications such as infections or local pain have been described, as well as less frequently but potentially fatal complications such as subarachnoid [...] Read more.

Acupuncture is an alternative medicine, actually it has had a greater acceptance in our continent being use for multiple therapeutic purposes. Although it is a minimally invasive procedure it is not exempt from complications, most common minor complications such as infections or local pain have been described, as well as less frequently but potentially fatal complications such as subarachnoid hemorrhage and tension pneumothorax. We report a case of pneumothorax secondary to acupuncture in a patient who was treated for carpal tunnel syndrome.

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Case Report

Open Access December 29, 2022

Antibiotic treatment for infection with Shiga toxin producing Escherichia coli infection inducing a hemolytic uremic syndrome

Lars Lindberg

Universal Journal of Pediatrics 2023, 1(1), 11-15. DOI: 10.31586/ujp.2023.559

Abstract Background: Shiga toxin producing Escherichia coli (STEC) inducing hemolytic uremic syndrome (HUS) with multiple organ involvement is associated with significant morbidity and mortality. The treatment has mostly been focused on kidney, respiratory and cardiovascular supports and not against the bacteria that cause STEC-HUS. The use of bactericidal therapy has been shown to be antibiotic [...] Read more.

Background: Shiga toxin producing Escherichia coli (STEC) inducing hemolytic uremic syndrome (HUS) with multiple organ involvement is associated with significant morbidity and mortality. The treatment has mostly been focused on kidney, respiratory and cardiovascular supports and not against the bacteria that cause STEC-HUS. The use of bactericidal therapy has been shown to be antibiotic dependent and certain antibiotics inhibit the production and release of Shiga toxin, eradicate STEC without harmful effects, and improve outcome. Methods: A previously healthy 18-months-old girl with STEC causing severe colitis, kidney failure and multi-organ dysfunction was treated with antibiotics that were known to inhibit the release of Shiga toxin as a supplement to supportive care. Results: The antibiotic regime stopped the pathophysiological process with prompt clinical improvement in association with the disappearance of the Shiga toxins. Conclusions: The present case report fortifies and recommends appropriate antibiotic treatment during STEC-HUS, suggesting clinicians to consider the use of these in severe STEC-HUS as early as possible.

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Case Report

Open Access August 21, 2021

Global Analysis of Potential COVID 19 Transmission and Enabling Factors

Hesham Magd, Henry Karyamsetty

Global Journal of Epidemiology and Infectious Disease 2021, 1(1), 46-61. DOI: 10.31586/gjeid.2021.010103

Abstract Background: Coronavirus disease has caused global turmoil especially causing huge impact on human life all over the world. Current reports states more than 3 million people have lost life and more than 160 million people are known to be suspected with the SARS-CoV-2. Transmission and disease incidence rates are indicators to assess the seriousness of COVID-19 pandemic and studies to understand the factors that aid in this direction are very vital to curb the disease. Methods: The study intends to discover the relationship by performing statistical analysis using correlation and multiple linear regression analysis between the variable’s population density, temperature, relative humidity, and active time of virus and find out the parameters that predict the cases reported per million population in 83 countries. Results: Analysis indicates active time of virus in days is very positively associated with the COVID -19 cases in all the countries r = .604, p < .01. Active time of virus shows strong negative correlation with temperature r = -.930, p [...] Read more.

Background: Coronavirus disease has caused global turmoil especially causing huge impact on human life all over the world. Current reports states more than 3 million people have lost life and more than 160 million people are known to be suspected with the SARS-CoV-2. Transmission and disease incidence rates are indicators to assess the seriousness of COVID-19 pandemic and studies to understand the factors that aid in this direction are very vital to curb the disease. Methods: The study intends to discover the relationship by performing statistical analysis using correlation and multiple linear regression analysis between the variable’s population density, temperature, relative humidity, and active time of virus and find out the parameters that predict the cases reported per million population in 83 countries. Results: Analysis indicates active time of virus in days is very positively associated with the COVID -19 cases in all the countries r = .604, p < .01. Active time of virus shows strong negative correlation with temperature r = -.930, p < .01 revealing that rise in temperature will reduce the virus activity in the population. Together, these variables will account for 36.2% variance in the cases per million population with no significant prediction estimated from any factor. Conclusion: The study outcomes clearly state that population density alone is insufficient to estimate the extent of influence on COVID -19 cases as the number of persons living per sq. km of land is a dynamic quantity tend to fluctuate over time and space due to migration of population. In conjunction to the previous studies reported on the environmental and climatic factors influencing the cases reported, population dynamics does not show much significance on the disease spread and incidence. Contribution: The rise in confirmed cases and the high incidence rate reported in countries can be attributed to the active time of virus life expectancy as there is a positive correlation observed between the COVID-19 cases reported and the virus active time in the examined countries. Also, environment and climatic factors play a role in modulating the infection and transmission rate with less significant influence of population density on the COVID-19.

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Article

Open Access May 20, 2021

Bioconcentration Factor of Polychlorinated Biphenyls and Its Correlation with UV- and IR-Spectroscopic data: A DFT based Study

Sangeeta Sahu, Vishnu Kumar Sahu, Anil Kumar Soni

Online Journal of Chemistry 2021, 1(1), 1-10. DOI: 10.31586/ojc.2021.010101

Abstract Polychlorinated biphenyls (PCBs) are important class of persist organic pollutants that were used as a component of paints especially in printings, as plastificator of plastics and insulating materials in transformers and capacitors, heat transfer fluids, additives in hydraulic fluids in vacuum and turbine pumps. There is always a need to establish reliable procedures for predicting the [...] Read more.

Polychlorinated biphenyls (PCBs) are important class of persist organic pollutants that were used as a component of paints especially in printings, as plastificator of plastics and insulating materials in transformers and capacitors, heat transfer fluids, additives in hydraulic fluids in vacuum and turbine pumps. There is always a need to establish reliable procedures for predicting the bioconcentration potential of chemicals from the knowledge of their molecular structure, or from readily measurable properties of the substance. Hence, correlation and prediction of biococentration factors (BCFs) based on λ_max and vibration frequencies of various bonds viz υ(C-H) and υ(C=C) of biphenyl and its fifty-seven derivatives have been made. For the study, the molecular modeling and geometry optimization of the PCBs have been performed on workspace program of CAChe Pro 5.04 software of Fujitsu using DFT method. UV-visible spectra for each compound were created by electron transition between molecular orbitals as electromagnetic radiation in the visible and ultraviolet (UV-visible) region is absorbed by the molecule. The energies of excited electronic states were computed quantum mechanically. IR spectra of transitions for each compound were created by coordinated motions of the atoms as electromagnetic radiation in the infrared region is absorbed by the molecule. The force necessary to distort the molecule was computed quantum mechanically from its equilibrium geometry and thus frequency of vibrational transitions was predicted. Project Leader Program associated with CAChe has been used for multiple linear regression (MLR) analysis using above spectroscopic data as independent variables and BCFs of PCBs as dependent variables. The reliability of correlation and predicting ability of the MLR equations (models) are judged by R², R²_adj, se, q²_L10O and F values. This study reflected clearly that UV and IR spectroscopic data can be used to predict BCFs of a large number of related compounds within limited time without any difficulty.

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Editorial Article

Open Access December 28, 2025

Acute Right Ovarian Torsion with Six Twists: Successful Ovarian Preservation Following Detorsion

Noreen Atif, Ahmed Mohamed Nouman Mohamed, Hosam Mohammed Leithy Sayed

Universal Journal of Obstetrics and Gynecology 2025, 4(1), 35-38. DOI: 10.31586/ujog.2025.6246

Abstract Introduction: Ovarian torsion is a rare gynecological emergency that can result in permanent ovarian loss if not promptly recognized and managed. Cases involving multiple rotations of the ovary are highly unusual and pose a significant risk for ovarian viability. Clinical Description: A 33-year-old P2 woman presented with sudden severe lower abdominal pain. Imaging showed a complex [...] Read more.

Introduction: Ovarian torsion is a rare gynecological emergency that can result in permanent ovarian loss if not promptly recognized and managed. Cases involving multiple rotations of the ovary are highly unusual and pose a significant risk for ovarian viability. Clinical Description: A 33-year-old P2 woman presented with sudden severe lower abdominal pain. Imaging showed a complex midline adnexal mass, more towards left and mild free fluid with suspected torsion. Emergency laparotomy showed a sixfold torsion of the right ovary with a dermoid cyst. Detorsion and cystectomy were performed with preservation of the ovary. Postoperative recovery was uneventful and histopathology further confirmed a benign dermoid cyst. Discussion: Ovarian torsion with multiple rotations is extremely rare so early recognition and timely surgical intervention enable ovarian salvage even in severe cases. Moreover, Dermoid cysts are the most common predisposing factor. Conclusion: This case highlights the importance of prompt diagnosis and immediate management of ovarian torsion to prevent complications, preserve ovarian integrity and fertility.

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Case Report

Open Access November 12, 2025

Effect of Sleep Deprivation on Executive Functioning Among Young Adults: Meta-Analysis

Misra Rajeev, Singh Divyanshi, Shukla Jahanvi, Mishra Akanksha, Reddy Rajgopal

Open Journal of Psychology 2025, 5(1), 79-87. DOI: 10.31586/ojp.2025.6215

Abstract Background: Sleep deprivation is increasingly prevalent among young adults due to academic, occupational, and social demands, making them susceptible to circadian disruption. Executive functioning—encompassing working memory, inhibitory control, and cognitive flexibility is essential for academic and professional success. This meta-analysis quantifies the effect of sleep deprivation on [...] Read more.

Background: Sleep deprivation is increasingly prevalent among young adults due to academic, occupational, and social demands, making them susceptible to circadian disruption. Executive functioning—encompassing working memory, inhibitory control, and cognitive flexibility is essential for academic and professional success. This meta-analysis quantifies the effect of sleep deprivation on executive functioning in healthy young adults. Practical Implications: These findings highlight the need for evidence-based interventions such as university-level sleep education programs, flexible academic scheduling, and workplace policies promoting adequate sleep to optimize cognitive performance and productivity among young adults. Methods: Following PRISMA 2020 guidelines, PubMed, Scopus, PsycINFO, and Web of Science were searched (January 2000–March 2024) for studies assessing acute (<6 hours sleep or ≥24 hours total deprivation) or chronic (<6 hours/night over multiple days) sleep deprivation in young adults. Outcomes included validated executive function tests (e.g., Stroop, N-Back). Random-effects meta-analysis (Hedges’ g) was conducted using R (version 4.3.2) with metafor/meta packages. Heterogeneity (I², Q-test), sensitivity (leave-one-out), and publication bias (funnel plot, Egger’s test) were evaluated. Results: Out of 2,478 screened studies, 39 met inclusion criteria (n=4,578). Sleep deprivation had a moderate-to-large detrimental effect on executive functioning (Hedges’ g = -0.62, 95% CI [-0.78, -0.45], p<0.001). Subdomain analysis revealed greatest impairment in working memory (g = -0.71), followed by inhibitory control (g = -0.59) and cognitive flexibility (g = -0.49) (all p<0.001). Moderate heterogeneity was present (I² = 58%), with results robust to sensitivity analysis. Egger’s test indicated no significant publication bias (p=0.22). Interpretation: Sleep deprivation significantly impairs executive functioning in young adults, especially working memory. Interventions improve sleep may enhance cognitive performance and should be integrated into public health strategies and educational policies. Future research should assess chronic restriction and individual vulnerability factors.

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Meta-Analysis

Open Access November 06, 2025

Ventral Attention Network Resting State Functional Connectivity: Psychosocial Correlates among US Adolescents

Shervin Assari, Alexandra Donovan, Babak Najand, Golnoush Akhlaghipour, Mario F Mendez

Journal of Biomedical and Life Sciences 2025, 5(2), 122-138. DOI: 10.31586/jbls.2025.6208

Abstract Background: Resting-state functional MRI (rsfMRI) provides insights into large-scale brain network organization associated with cognitive control, emotion regulation, and attentional processes. The ventral attention network (VAN) is a key salience-driven network that supports attentional re-orienting to behaviorally relevant stimuli. However, little is known about how VAN [...] Read more.

Background: Resting-state functional MRI (rsfMRI) provides insights into large-scale brain network organization associated with cognitive control, emotion regulation, and attentional processes. The ventral attention network (VAN) is a key salience-driven network that supports attentional re-orienting to behaviorally relevant stimuli. However, little is known about how VAN resting state functional connectivity varies by demographic, socioeconomic, psychosocial, and behavioral factors during early adolescence. Objective: To examine associations between VAN rsfMRI connectivity and multiple demographic, socioeconomic, psychosocial, and behavioral characteristics. Methods: Data came from the baseline and early follow-up waves of the Adolescent Brain Cognitive Development (ABCD) Study. The analytic sample included youth with high-quality baseline rsfMRI data and complete socioeconomic and psychosocial measures. The primary outcome was mean resting-state functional connectivity within the VAN across subcortical and cortical regions of interest (ROIs). Bivariate correlations were computed between VAN connectivity and demographic (age, sex, puberty, race/ethnicity), socioeconomic (income, parental education, marital status, neighborhood income), psychosocial (trauma, discrimination, financial difficulty), trait (impulsivity), and behavioral variables (body mass index, depression, suicide, prodromal symptoms, and substance use). Unadjusted bivariate correlations and adjusted logistic regressions were used for data analysis. Results: VAN connectivity showed small but significant correlations with multiple contextual factors. Higher household income, parental education, and neighborhood affluence were associated with greater connectivity, whereas Black race and Hispanic ethnicity were related to lower connectivity. Youth reporting higher discrimination and financial difficulty exhibited weaker VAN connectivity. Greater VAN connectivity was negatively associated with impulsive reward-driven trait (drive), prodromal symptoms, BMI, and marijuana and alcohol use. Associations between VAN connectivity and suicide, depression, marijuana use, and alcohol use remained significant in age and sex adjusted models. Conclusions: VAN connectivity reflects subtle neural correlates of socioeconomic and psychosocial context in early adolescence. Our results underscore the importance of integrating structural and contextual factors in interpreting brain-behavior associations across diverse populations. These findings are suggestive of stable socioeconomic and psychosocial correlates of network efficiency.

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Article

Open Access May 05, 2025

Educated Yet Unhealthy? Diminished Returns of Education for Immigrants in the USA

Shervin Assari, Babak Najand, Hossein Zare

Journal of Biomedical and Life Sciences 2025, 5(1), 84-97. DOI: 10.31586/jbls.2025.1106

Abstract Background: Minorities’ Diminished Returns (MDRs) theory posits that the health benefits of socioeconomic resources, such as education, are smaller for marginalized and minoritized populations, including immigrants. While MDRs have been extensively documented for racial and ethnic minorities, less is known about whether these diminished returns extend to immigrant populations. This study [...] Read more.

Background: Minorities’ Diminished Returns (MDRs) theory posits that the health benefits of socioeconomic resources, such as education, are smaller for marginalized and minoritized populations, including immigrants. While MDRs have been extensively documented for racial and ethnic minorities, less is known about whether these diminished returns extend to immigrant populations. This study tested MDRs of education on various health and cognitive outcomes, including self-rated health (SRH), cognitive function, numeracy, number of chronic medical conditions, and limitations in activities of daily living (ADLs) among immigrants compared to non-immigrants in the United States. Objective. To examine whether educational attainment confers weaker protective effects on SRH, cognitive function, numeracy, chronic medical conditions, and ADLs in immigrants compared to non-immigrants, confirming the presence of MDRs across these domains. Methods: We used data from the Understanding America Study (UAS), a nationally representative survey of U.S. adults. We tested the association between educational attainment and five outcomes—SRH, cognitive function, numeracy, number of chronic medical conditions, and limitations in ADLs—across immigrant and non-immigrant groups. Multivariate regression models were employed, adjusting for key sociodemographic covariates. Results: The protective effects of education on a range of health outcomes were significantly weaker for immigrants compared to non-immigrants. Education level showed weaker associations with SRH, cognitive function, numeracy, number of chronic conditions, and ADLs among immigrants. These findings suggest that even at higher levels of educational attainment, immigrants experience poorer health and cognitive functioning than their U.S.-born counterparts. Conclusion: This study offers strong evidence for the MDRs of education on multiple health outcomes among U.S. immigrants. One possible explanation is that, despite achieving higher levels of education, immigrants often face structural barriers—such as discrimination, limited access to resources, and economic inequities—that constrain the health-related benefits typically associated with educational attainment. Additionally, a portion of immigrant education may be acquired outside the United States, where credentials may not be fully recognized or rewarded within the U.S. labor market. These findings highlight the importance of policies aimed at addressing systemic inequities and improving access to healthcare, employment opportunities, and social support for immigrant communities. Future research should further explore the mechanisms underlying these diminished returns and identify policy solutions to reduce their impact. Keywords: Educational Attainment, Immigrants, Nativity, Self-Rated Health, Chronic Disease, Activities of Daily Living (ADL), Cognitive Function

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Open Access April 03, 2025

Depression, Subjective Health, Obesity, and Multimorbidity are Associated with Epigenetic Age Acceleration

Shervin Assari, John Ashley Pallera

Journal of Biomedical and Life Sciences 2025, 5(1), 42-57. DOI: 10.31586/jbls.2025.6041

Abstract Background: Epigenetic aging, measured through various DNA methylation-based clocks, may have implications for predicting disease risk. However, the sensitivity of different epigenetic clocks that have emerged as biomarkers for biological aging and in predicting physical and mental health outcomes remains uncertain. This study examines the age and sex-adjusted associations between [...] Read more.

Background: Epigenetic aging, measured through various DNA methylation-based clocks, may have implications for predicting disease risk. However, the sensitivity of different epigenetic clocks that have emerged as biomarkers for biological aging and in predicting physical and mental health outcomes remains uncertain. This study examines the age and sex-adjusted associations between multiple epigenetic age acceleration measures and three key health indicators, including self-rated health, depressive symptoms, and body mass index (BMI), in a nationally representative sample of U.S. middle-aged and older adults. Methods: We analyzed data from 4,018 adults in the 2016 wave of the Health and Retirement Study (HRS), which included several epigenetic age acceleration measures: HORVATH, HANNUM, LEVINE, HORVATHSKIN, LIN, WEIDNER, VIDALBRALO, YANG, ZHANG, BOCKLANDT, GARAGNANI, and GRIMAGE. Linear regression models were used to assess the associations between epigenetic age acceleration and self-rated health (poor health), depressive symptoms, and BMI, adjusting for age and sex. Results: We found significant positive associations between epigenetic age acceleration and worse self-rated health, higher depressive symptoms, and increased BMI. However, these associations varied across different epigenetic clocks, with some measures potentially having more consistent utility for specific health outcomes than others. Conclusion: Epigenetic age acceleration is linked to poorer self-rated health, greater depressive symptoms, and higher BMI, but choosing which epigenetic clock(s) to use is also important. These findings underscore the need to consider multiple epigenetic aging markers when assessing health risks and highlight the potential for particular clocks to serve as more sensitive indicators of physical and mental health outcomes.

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Open Access February 24, 2025

Socioeconomic Status, Trauma, Cognitive Function, Impulsivity, Reward Salience, and Future Substance Use: Role of Left Caudate Connectivity with the Cingulo-Opercular Network

Shervin Assari, Hossein Zare, Golnoush Akhlaghipour, Mario F Mendez

Journal of Cellular Neuroscience 2025, 1(1), 46-61. DOI: 10.31586/jcn.2025.1264

Abstract Background: While understanding how corticostriatal connectivity is associated with socioeconomic status (SES), trauma exposure, cognitive function, reward salience, impulsivity, and future substance use is essential to identifying neurobiological pathways that contribute to health disparities and behavioral outcomes, very few studies have tested the role of left caudate resting-state [...] Read more.

Background: While understanding how corticostriatal connectivity is associated with socioeconomic status (SES), trauma exposure, cognitive function, reward salience, impulsivity, and future substance use is essential to identifying neurobiological pathways that contribute to health disparities and behavioral outcomes, very few studies have tested the role of left caudate resting-state functional connectivity (rsFC) with the cingulo-opercular network as a proxy of corticostriatal connectivity in social, cognitive, and behavioral processes. Objective: This study investigates the associations between left caudate-cingulo-opercular connectivity and multiple biopsychosocial domains, including low SES, high trauma exposure (financial and life events), cognitive function, reward salience, impulsivity, depression, and future substance use (tobacco and marijuana use). Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were analyzed to assess connectivity between the left caudate and the cingulo-opercular network. Data on socioeconomic status, trauma exposure, cognitive performance, and mental health were collected from participants. Future substance use behaviors were evaluated through longitudinal follow-ups. Correlation and regression analyses were conducted to examine relationships between corticostriatal connectivity and the targeted domains. Results: Corticostriatal hypoconnectivity was associated with lower SES, higher trauma exposure, poorer cognitive function, heightened reward salience, higher impulsivity, and history of depression. Additionally, corticostriatal hypoconnectivity at baseline predicted future tobacco and marijuana use during follow-up years. Conclusion: Corticostriatal hypoconnectivity, particularly the rsFC between the left caudate and the cingulo-opercular network, may represent a potential mechanism linking a wide range of social, emotional, and behavioral problems in youth. These findings suggest that corticostriatal hypoconnectivity could serve as a neurobiological marker for identifying individuals at risk for depression, low cognitive function, high reward salience, impulsivity, and substance use, emphasizing the interplay between socioeconomic and neurocognitive factors in shaping behavioral health trajectories.

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Open Access February 14, 2025

Trauma Erodes Financial Returns of Educational Attainment

Shervin Assari, Alexandra Donovan

Open Journal of Educational Research 2025, 5(1), 40-53. DOI: 10.31586/ojer.2025.1199

Abstract Background: Educational attainment is often regarded as a pathway to economic stability and social mobility. However, the Minorities’ Diminished Returns (MDRs) framework has demonstrated that the effects of educational attainment on various economic, behavioral, and health outcomes are weaker for marginalized populations, including racial/ethnic minorities, immigrants, LGBTQ+ individuals, [...] Read more.

Background: Educational attainment is often regarded as a pathway to economic stability and social mobility. However, the Minorities’ Diminished Returns (MDRs) framework has demonstrated that the effects of educational attainment on various economic, behavioral, and health outcomes are weaker for marginalized populations, including racial/ethnic minorities, immigrants, LGBTQ+ individuals, and those living in disadvantaged areas. While MDRs have been documented for various marginalized demographic groups, the role of trauma in moderating socioeconomic outcomes remains underexplored. Objective: This study examines whether lifetime trauma exposure diminishes the positive association between educational attainment and poverty-to-income ratio (PIR), a key indicator of economic well-being. Methods: Using data from the National Survey of American Life (NSAL), we analyzed a nationally representative sample of 6,008 adults, including Black, White, Latino, and Other racial/ethnic groups. We employed linear regression models to evaluate the association between the independent variable educational attainment and the outcome PIR. We then tested lifetime trauma as a moderator of this association. Models controlled for age, gender, employment, and race/ethnicity. Results: Educational attainment was positively associated with PIR across all groups, but the strength of this association was significantly attenuated for individuals with a history of lifetime trauma. These effects were independent of covariates. Conclusions: These findings extend the MDRs framework by highlighting trauma as a potential contributor to diminished returns of education on socioeconomic wellbeing. Structural inequities that increase trauma exposure in minoritized populations may also limit the economic benefits of education, particularly for groups with multiple trauma exposures. Policies aimed at addressing economic inequality must integrate social policies that reduce trauma and stress.

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Open Access January 10, 2025

Extreme Heat Exposure is Associated with Lower Learning, General Cognitive Ability, and Memory among US Children

Shervin Assari, Hossein Zare

Open Journal of Neuroscience 2025, 3(1), 10-22. DOI: 10.31586/ojn.2025.1277

Abstract Background: The increasing frequency and intensity of extreme heat exposure is a significant consequence of climate change, with broad public health implications. While many health risks associated with heat exposure are well-documented, less research has focused on its impact on children’s cognitive function. Objectives: This study examines the [...] Read more.

Background: The increasing frequency and intensity of extreme heat exposure is a significant consequence of climate change, with broad public health implications. While many health risks associated with heat exposure are well-documented, less research has focused on its impact on children’s cognitive function. Objectives: This study examines the relationship between extreme heat exposure and various domains of cognitive function in children. Methods: Data were drawn from the Adolescent Brain Cognitive Development (ABCD) study. Key variables included race/ethnicity, age, gender, family socioeconomic status (SES), heatwave exposure, and multiple cognitive domains: total composite score, fluid composite score, crystallized intelligence, reading ability, picture vocabulary, pattern recognition, card sorting, and list recall. Structural equation modeling (SEM) was used for data analysis. Results: A total of 11,878 children were included in the analysis. Findings revealed significant associations between extreme heat exposure and lower cognitive performance across multiple domains. The strongest adjusted effects were observed in pattern recognition (B = −0.064, p < 0.001) and reading ability (B = −0.050, p < 0.001), both within the learning domain, as well as total composite cognitive ability (B = −0.067, p < 0.001), fluid composite (B = −0.053, p < 0.001), and crystallized intelligence (B = −0.061, p < 0.001), all within general cognitive ability. Weaker but still significant associations were found for list recall (B = −0.025, p = 0.006) and card sorting (B = −0.043, p < 0.001) within the memory domain, as well as picture vocabulary (B = −0.025, p = 0.008) within general cognitive ability. These associations remained significant after controlling for demographic factors, race/ethnicity, family SES, and neighborhood SES. Conclusions: This study underscores the impact of climate change on cognitive function disparities, particularly in learning and general cognitive ability among children exposed to extreme heat. Findings highlight the need for targeted interventions to mitigate the cognitive risks associated with heat exposure in vulnerable populations.

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Open Access January 24, 2025

High Socioeconomic Status Black Adolescents Attend Worse Schools than Whites

Shervin Assari, Hossein Zare

Open Journal of Educational Research 2025, 5(1), 1-12. DOI: 10.31586/ojer.2025.1160

Abstract Background: School characteristics — including poverty levels, teacher experience, graduation rates, and college enrollment — are essential determinants of students’ academic outcomes and long-term success. Families often use their socioeconomic resources, such as parental education and household income, to secure access to high-quality schools with favorable attributes. However, [...] Read more.

Background: School characteristics — including poverty levels, teacher experience, graduation rates, and college enrollment — are essential determinants of students’ academic outcomes and long-term success. Families often use their socioeconomic resources, such as parental education and household income, to secure access to high-quality schools with favorable attributes. However, Minorities’ Diminished Returns (MDRs) theory suggests that Black families may not experience the same benefits of high family SES due to structural barriers. This study examines the association between family SES and school characteristics, focusing on racial disparities in access to high-quality educational environments. Objective: To investigate the relationship between family SES (parental education and household income) and multiple school characteristics (poverty, teacher experience, graduation rates, and college enrollment), and to assess racial differences in these associations. Methods: Data from the Adolescent Brain Cognitive Development (ABCD) study, a national sample of US adolescents, was analyzed. We used multivariate regression models to examine associations between family SES and school characteristics and to test for interactions by race, specifically comparing Black and White adolescents. Results: Higher family SES was associated with positive school characteristics overall, including lower school poverty, greater teacher experience, and increased graduation and college enrollment rates. However, these positive effects of high family SES on school characteristics were significantly weaker for Black adolescents than for White adolescents. Black adolescents from high-income families were more likely than White adolescents from similar backgrounds to attend schools with higher poverty rates, less experienced teachers, and reduced graduation and college enrollment rates. Conclusion: Our findings highlight persistent racial inequities in access to educational opportunities, even among families with comparable socioeconomic resources. The diminished returns of family SES for Black adolescents underscore the role of structural barriers in limiting access to high-quality schools. These findings emphasize the need for policy interventions to address systemic inequalities that hinder Black families from fully leveraging their SES to access favorable educational environments.

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Article

Open Access October 30, 2024

Smokers with Multiple Chronic Disease Are More Likely to Quit Cigarette

Shervin Assari, Payam Sheikhattari

Global Journal of Epidemiology and Infectious Disease 2024, 4(1), 60-68. DOI: 10.31586/gjeid.2024.1068

Abstract Objective: This study aims to investigate the relationship between the presence of chronic medical conditions and cessation among U.S. adults who use combustible tobacco. We hypothesized that having chronic medical conditions would be associated with a higher likelihood of successfully quitting combustible tobacco. Methods: We utilized longitudinal data from the Population [...] Read more.

Objective: This study aims to investigate the relationship between the presence of chronic medical conditions and cessation among U.S. adults who use combustible tobacco. We hypothesized that having chronic medical conditions would be associated with a higher likelihood of successfully quitting combustible tobacco. Methods: We utilized longitudinal data from the Population Assessment of Tobacco and Health (PATH) Study, using data from Waves 1 to 6. Only current daily smokers were included in our analysis. The independent variable was the number of chronic medical conditions, defined as zero, one, or two or more. The outcome was becoming a former smoker (quitting smoking). Using multivariate regression analyses, we assessed the association between the number of chronic conditions and tobacco cessation over the six waves. We controlled for potential confounding variables, including demographic factors and socioeconomic status. Results: Our analysis revealed a significant association between the number of chronic medical conditions and the likelihood of quitting smoking. Specifically, individuals with two or more chronic conditions exhibited a greater probability of quitting smoking compared to those with no chronic conditions. The results remained significant after adjusting for potential confounders. Conclusions: Multiple chronic medical conditions may act as a catalyst for smoking cessation among U.S. adults. This suggests that the presence of multimorbidity, defined as multiple chronic disease diagnoses, may serve as “teachable moments,” prompting significant health behavior changes. These findings highlight the potential for leveraging chronic disease management and healthcare interventions to promote tobacco cessation, particularly among individuals with multiple chronic conditions.

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Open Access October 21, 2024

Sexual Harassment in Ghanaian Tertiary Institutions: Reality or Perception

Wahab Sualihu, Mohammed Zakaria, Victor Owusu

Universal Journal of Social Sciences and Humanities 2024, 4(2), 74-88. DOI: 10.31586/ujssh.2024.1085

Abstract This article assesses the realities of sexual harassment (SH) in selected tertiary educational institutions in Ghana. Using multiple data collection techniques, three areas that are related to SH were assessed. These are knowledge of what constitutes SH, the nature and incidence of SH, and strategies/procedures for handling issues of SH in tertiary educational institutions. The findings from the [...] Read more.

This article assesses the realities of sexual harassment (SH) in selected tertiary educational institutions in Ghana. Using multiple data collection techniques, three areas that are related to SH were assessed. These are knowledge of what constitutes SH, the nature and incidence of SH, and strategies/procedures for handling issues of SH in tertiary educational institutions. The findings from the perspective of teaching and non-teaching staff strongly suggest that knowledge of SH was high among teaching staff but low among non-teaching staff. Staff could not relate very well to the reporting systems and procedures of SH in their institutions. Issues of SH were left in the hands of only a few staff while newly recruited staff showed little understanding of the reporting systems and procedures. From the perspective of students, knowledge of what constitutes SH was high. Students were able to indicate the various SH reporting systems/procedures in the tertiary educational institutions and further indicated that the institutions have provided a safe environment and appointed designated people to handle sexual harassment complaints. Surprisingly, the incidence of sexual harassment was low, and this affected sexual harassment reporting.

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Open Access October 19, 2024

Quantitative Intersectionality Scoring System (QISS): Opportunities for Enhancing Predictive Modeling, Comparative Analysis, Health Needs Assessment, and Policy Evaluation

Shervin Assari, Hossein Zare

Journal of Social Mathematical & Human Engineering Sciences 2024, 3(1), 49-61. DOI: 10.31586/jsmhes.2024.1066

Abstract Intersectionality has significantly enhanced our understanding of how overlapping social identities—such as race, ethnicity, gender, sex, class, and sexual orientation—interact to shape individual experiences. However, despite its theoretical importance, much of the existing literature has relied on qualitative approaches to define and study intersectionality, limiting its application in [...] Read more.

Intersectionality has significantly enhanced our understanding of how overlapping social identities—such as race, ethnicity, gender, sex, class, and sexual orientation—interact to shape individual experiences. However, despite its theoretical importance, much of the existing literature has relied on qualitative approaches to define and study intersectionality, limiting its application in predictive modeling, comparative analysis, and policy development. This paper introduces the concept of Quantitative Intersectionality Scoring System (QISS), a novel approach that assigns numerical scores to intersecting identities, thereby enabling a more systematic and data-driven analysis of intersectional effects. We argue that QISS can substantially enhance the utility and predictive validity of quantitative models by capturing the complexities of multiple, overlapping social determinants. By presenting concrete examples, such as the varying impacts of socioeconomic mobility on life expectancy among different intersectional groups, we demonstrate how QISS can yield more precise and reliable forecasts. Such a shift would allow policymakers and service providers to dynamically assess economic and health needs, as well as the uncertainties around them, as individuals move through different social and economic contexts. QISS-based models could be more responsive to the complexities of intersecting identities, allowing for a more quantified and nuanced evaluation of policy interventions. We conclude by discussing the challenges of implementing QISS and emphasizing the need for further research to validate these quantifications using robust quantitative methods. Ultimately, adopting QISS has the potential to improve the accuracy of predictive models and the effectiveness of policies aimed at promoting social justice and health equity.

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Open Access August 29, 2024

Adversities Mediate Social Determinants of Youth Tobacco Use Initiation

Shervin Assari, Payam Sheikhattari, Hossein Zare

Journal of Biomedical and Life Sciences 2024, 4(1), 15-26. DOI: 10.31586/jbls.2024.1039

Abstract Background: Social determinants of health (SDOH) significantly influence health behaviors, including tobacco use among youth. Adversities such as perceived discrimination, perceived neighborhood stress, life trauma, and financial strain are stressors that may mediate the relationship between various SDOH and youth tobacco use. This study aims to investigate whether multidimensional adversities [...] Read more.

Background: Social determinants of health (SDOH) significantly influence health behaviors, including tobacco use among youth. Adversities such as perceived discrimination, perceived neighborhood stress, life trauma, and financial strain are stressors that may mediate the relationship between various SDOH and youth tobacco use. This study aims to investigate whether multidimensional adversities mediate the effects of SDOH on tobacco use among youth. Methods: Data from the Adolescent Brain Cognitive Development (ABCD) study were used to test our hypotheses. The sample included a diverse cohort of youth aged 9-10 years old followed until they were 15-16 years old. We examined the effects of baseline parental education, household income, neighborhood income, and family structure on subsequent youth tobacco use. Structural equation models were used to test if adversities (perceived discrimination, life trauma, financial strain) operate as potential mediators. Results: All ABCD participants were eligible for our analysis, regardless of race, ethnicity, or SDOHs (n = 11,878). The findings indicated that the effects of parental education, household income, neighborhood income, and family structure on youth tobacco use were partially mediated by adversities. Higher levels of parental education and household income were associated with lower tobacco use, and this relationship was weakened when accounting for adversities. Similarly, stable family structures and higher neighborhood income were linked to reduced tobacco use, with adversities playing a mediating role. Conclusions: Multidimensional adversities partially mediate the relationship between SDOH at baseline and subsequent youth tobacco use. Interventions aimed at reducing youth tobacco use should address both the social determinants and multiple adversities experienced by adolescents. Policies to improve the educational and economic situations of families, enhance neighborhood environments, and support stable family structures all reduce youth tobacco use, with lower exposure to adversities explaining this effect.

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Open Access January 23, 2024

Ethical assessment of the culture clash as a universal occurrence

Gentian Vyshka

Journal of Art and Design 2024, 4(1), 1-5. DOI: 10.31586/jad.2024.862

Abstract The debate on culture clash necessitates a theoretical framework, and three perspectives that merit attention are homogenization, polarization, and hybridization theories. These intersecting paths lead to the hypothesis that all civilizations could assimilate into the Western model as it is currently conceived. Culture clash is approached from multiple angles due to the widely held belief that [...] Read more.

The debate on culture clash necessitates a theoretical framework, and three perspectives that merit attention are homogenization, polarization, and hybridization theories. These intersecting paths lead to the hypothesis that all civilizations could assimilate into the Western model as it is currently conceived. Culture clash is approached from multiple angles due to the widely held belief that rejecting culturally novel concepts is unethical. However, imposing new rules and customs will inevitably encounter innate resistance, as evidenced by numerous examples. The exchange of behavioral models does exist, with one of globalization's main tenets being the universality of values – including the uprooting of what we refer to as primitive manners. Nevertheless, anthropology and cultural research have witnessed intergenerational and long-term survival of elements that contemporary civilization believed it had overcome or at least suppressed deep within the subconscious mind. This article will offer an essayistic approach to certain forms of culture clash.

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Open Access October 20, 2023

Factors Influencing Fertility Control among Highly-Educated Urban Women in the Cape Coast Metropolis of Ghana

Joseph Boateng, Liyab John Tachin

Universal Journal of Social Sciences and Humanities 2023, 3(2), 80-90. DOI: 10.31586/ujssh.2023.799

Abstract Fertility control is crucial to achieving improved health and socio-economic status of women. The main objective of the study was to explore fertility control behaviours among educated urban women in the Cape Coast Metropolis. The study adopted the interpretivist (qualitative) philosophy in social research. The population for the study comprised women who have at least secondary-level education, are married or in a stable union and are between the ages of 18 and 49 years. A snowball sampling technique was used to select thirty-two (32) respondents for the study. The respondents constituted the number that provided the required information at saturation. The main instrument for data collection was a semi-structured interview guide. Data was collected from educated women within the Cape Coast Metropolis. Five items open-ended questions under the heading Factors influencing fertility control among highly-educated urban women in the Cape Coast Metropolis [...] Read more.

Fertility control is crucial to achieving improved health and socio-economic status of women. The main objective of the study was to explore fertility control behaviours among educated urban women in the Cape Coast Metropolis. The study adopted the interpretivist (qualitative) philosophy in social research. The population for the study comprised women who have at least secondary-level education, are married or in a stable union and are between the ages of 18 and 49 years. A snowball sampling technique was used to select thirty-two (32) respondents for the study. The respondents constituted the number that provided the required information at saturation. The main instrument for data collection was a semi-structured interview guide. Data was collected from educated women within the Cape Coast Metropolis. Five items open-ended questions under the heading Factors influencing fertility control among highly-educated urban women in the Cape Coast Metropolis. All transcribed data were then imported into NVivo 11, a computer-aided qualitative data analysis package with each transcript coded sentence by sentence. The codes were determined and constructed based on the content of the data. After the coding process, each code was described and memos attached as ideas about the themes emerged from social-cultural, economic to educational factors. The study underscores the adequate involvement of male partners in women’s fertility control practices, especially women’s contraceptive preferences. This demonstrates the authority of men over women in the domain of the family. Recognising that men have enormous powers regarding fertility issues tend to appreciate the need to promote and advance family needs and welfare. Also, the results indicate that other close associates or relatives are involved in women’s contraceptive lives. These close relations are what describes as a social network in Bronfenbrenner social-ecological framework. Besides, there are multiple socio-cultural and economic obstacles that could work against achieving desired fertility levels. It is recommended that family planning programmes should not focus on only women, but include male partners to enhance a change in behaviour and norms regarding power and gender roles that do not make them supportive partners. There is a need for a high-level promotion through civil society to encourage men to get involved in family planning matters. This will help women or couples to freely adopt their desired fertility control methods without hindrance.

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Open Access June 28, 2023

At the center of it all: How personality amplifies centrality’s effects on physics ability

Hans Muehsler

Open Journal of Educational Research 2023, 3(2), 122-134. DOI: 10.31586/ojer.2023.661

Abstract The social aspect of education is an important part of the learning process. In this study two research questions were asked to explore this idea. Social network analysis provided multiple measures of AP Physics 1 students’ network centrality. These measures were used to predict physics achievement. Further, survey results measuring extroversion (EPI, alpha=.84-.94), motivation (PGOS, [...] Read more.

The social aspect of education is an important part of the learning process. In this study two research questions were asked to explore this idea. Social network analysis provided multiple measures of AP Physics 1 students’ network centrality. These measures were used to predict physics achievement. Further, survey results measuring extroversion (EPI, alpha=.84-.94), motivation (PGOS, alpha=.64-.83), and self-efficacy (SOSESC, alpha=.94) were used to determine students’ personality characteristics. These personality results were used as moderators for the moderation analysis. The sample consisted of 106 students from a large, Midwestern, suburban high school taking AP Physics 1. Numerous centrality measures significantly correlated with physics achievement. Extroversion and self-efficacy increased the effect of centrality in most cases, whereas motivation did not change the centrality-achievement relationship. In most cases, having many, high quality connections was beneficial to learning physics, but personality characteristics must also be included in pedagogical decisions. Based on the results, teachers are strongly advised to account for personality and student connections when forming groups.

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Open Access June 27, 2023

Teachers’ Knowledge Base in Community Resources Used in Assessing Social Studies Concepts

Emmanuel Brew

Open Journal of Educational Research 2023, 3(2), 105-121. DOI: 10.31586/ojer.2023.711

Abstract The purpose of this study was to examine teachers’ knowledge base in community resources used in assessing Social Studies concepts in the University of Education Practice Junior High School (JHS), Winneba. The case study design was employed as the study's qualitative methodology. The population comprised two Social Studies teachers in the University Practice JHS, Winneba. Purposive and convenient [...] Read more.

The purpose of this study was to examine teachers’ knowledge base in community resources used in assessing Social Studies concepts in the University of Education Practice Junior High School (JHS), Winneba. The case study design was employed as the study's qualitative methodology. The population comprised two Social Studies teachers in the University Practice JHS, Winneba. Purposive and convenient sampling techniques were used to select the teachers and school for the study. The main instrument for data collection was the interview guide. The two teachers were interviewed because they were in a position to give all the relevant information required for the research. They were also readily available at the time of the research. The study revealed that even though the Social Studies teachers were aware of community resources, they did not involve them often in their lesson delivery. However, in the only case where a teacher took the learners round the school compound to look at the various types of rocks, the learners were excited and willing to learn. The assessment results also showed that almost all learners, both low and high achievers had high scores. Evidence from the inquiry also shows that teachers used only traditional forms of assessment in Social Studies. Teachers give multiple choice and essay type of assessment items to learners. Teachers did not involve community resources in the assessment of Social Studies concepts because of challenges like inadequate time allocated for the teaching of the subject, financial constraints, bureaucratic processes involved in obtaining permission and the need to meet the requirements of external examinations. It is recommended that the Ghana Education Service (GES) should design appropriate policies to ensure that provision is made in the school academic calendar for field trips and community resource engagement for Social Studies education. Social Studies teachers should also be trained on the full range of assessment techniques suggested in the 2012 syllabus. Emphasis should be laid on authentic/alternate assessment practices. At the school level, heads of Social Studies department should organise periodic in-service training for the teachers to ensure that the curriculum, instruction and assessment practices are aligned to ensure that the subject attains its intended goals and outcomes.

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Open Access December 17, 2022

A Descriptive Phenomenology of Nature and Characteristics of Chieftaincy Succession Conflict: A Case of Akuapem Traditional Area, Ghana

Shirley Dankwa, Ernest Kumi, Isaac Eshun

Universal Journal of Social Sciences and Humanities 2022, 2(4), 291-309. DOI: 10.31586/ujssh.2022.572

Abstract The study focused on the nature and characteristics of the chieftaincy succession conflict in the Akuapem Traditional Area of Ghana. This study was anchored on an interpretivist philosophical viewpoint. Methodologically, the study employed a qualitative approach with a descriptive phenomenology research design. Thirty-four (34) adults who have lived in the area for the past five years [...] Read more.

The study focused on the nature and characteristics of the chieftaincy succession conflict in the Akuapem Traditional Area of Ghana. This study was anchored on an interpretivist philosophical viewpoint. Methodologically, the study employed a qualitative approach with a descriptive phenomenology research design. Thirty-four (34) adults who have lived in the area for the past five years participated in the study. They included members of the traditional council, the Akuapem North Municipal Assembly, the royal gates to the paramountcy and others within the community. Participants were selected using extreme case, critical case and convenience sampling techniques. Data were collected with the use of interview guide, focus-group discussion and observation protocols. The data collected were analysed thematically in line with the research questions and emerged patterns from the dataset. The study found out that the dynamics of the conflict revolved around the nature and frames. The findings showed multiple causes that resulted in the exacerbation of the conflict. A major conclusion drawn from the study was that the chieftaincy institution in Akuapem is hurled with conflict which has complex dynamics and thus, has had multiple implications on the stability and development of the society. It is therefore recommended that all stakeholders to the installation are duly left to perform their duties without any intrusion from external parties or outsiders. Moreover, the grievances of these stakeholders should be addressed to ensure smooth running of the processes. This can be ensured by the traditional council of the area.

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Open Access November 04, 2022

Long Term Outcomes and Survivorship of Bilateral Lower Limb Arthroplasties in Patients with Multiple Epiphyseal Dysplasia

Darshan S Angadi, Ravi Kumar Mukartihal, Jacob Eapen, Preetam Raj Chandran, Bhavin Agrawal, Sharan S Patil

Global Journal of Orthopedics 2022, 1(1), 11-23. DOI: 10.31586/gjo.2022.430

Abstract Background: Multiple epiphyseal dysplasia (MED) a rare form of skeletal dysplasia with early-onset osteoarthritis affecting the hip and knee joints. There is paucity of evidence regarding the long term outcomes of arthroplasty in this patient cohort. This is the first study to describe the outcomes of bilateral arthroplasty of the hip and knee in patients with MED. Methods: A prospective study of patients with MED who underwent bilateral staged total hip arthroplasty (THA) and bilateral simultaneous total knee arthroplasty (TKA) between July 2013 to April 2014. Preoperative and postoperative clinical and radiographic assessment including functional outcomes namely Merle d’aubigne score, Harris hip score (HHS), Knee society score (KSS) and numeric rating scale (NRS) for pain were recorded in prospective database and evaluated. Results: 3 patients (female - 1 / male - 2) with MED who underwent bilateral lower limb arthroplasty of the hip and knee were reviewed periodically with an average followup of 7.31 years. Mean preoperative Merle d'Aubigné score (6.33 ± 0.58), HHS (31.83 ± 5.31) and KSS (28.67 ± 7.97) increased following bilateral lower limb arthroplasty with mean postoperative Merle d'Aubigné score (16.33 ± 0.58), HHS (84.33 ± 5.99) and KSS (86.33 ± 7.09) (P<0.001). Mean NRS decreased from 7.33 ± 0.58 in the preoperative period to 0.67 ± 0.58 at the most recent followup (P [...] Read more.

Background: Multiple epiphyseal dysplasia (MED) a rare form of skeletal dysplasia with early-onset osteoarthritis affecting the hip and knee joints. There is paucity of evidence regarding the long term outcomes of arthroplasty in this patient cohort. This is the first study to describe the outcomes of bilateral arthroplasty of the hip and knee in patients with MED. Methods: A prospective study of patients with MED who underwent bilateral staged total hip arthroplasty (THA) and bilateral simultaneous total knee arthroplasty (TKA) between July 2013 to April 2014. Preoperative and postoperative clinical and radiographic assessment including functional outcomes namely Merle d’aubigne score, Harris hip score (HHS), Knee society score (KSS) and numeric rating scale (NRS) for pain were recorded in prospective database and evaluated. Results: 3 patients (female - 1 / male - 2) with MED who underwent bilateral lower limb arthroplasty of the hip and knee were reviewed periodically with an average followup of 7.31 years. Mean preoperative Merle d'Aubigné score (6.33 ± 0.58), HHS (31.83 ± 5.31) and KSS (28.67 ± 7.97) increased following bilateral lower limb arthroplasty with mean postoperative Merle d'Aubigné score (16.33 ± 0.58), HHS (84.33 ± 5.99) and KSS (86.33 ± 7.09) (P<0.001). Mean NRS decreased from 7.33 ± 0.58 in the preoperative period to 0.67 ± 0.58 at the most recent followup (P<0.001). One patient had heterotrophic ossification following THA. There were no revisions. Conclusions: Bilateral lower limb arthroplasty of the hip and knee is a good treatment option to restore function and mobility in MED patients with advanced degenerative arthritis. Careful preoperative planning, meticulous surgical techniques, patient focussed postoperative rehabilitation with multidisciplinary team approach are vital to ensure good functional outcomes and implant survivorship.

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Case Series

Open Access October 24, 2022

Probiotics and Intestinal Microbiome: A Review of Literature

Hadeer Abdel-Aleem Hassan Mohamed Tawfik, Mohamed Nazmy Farris, Rasha Samir, Mohamed Nabil Badawy Al Ashram, Mina Mikhail Nessim, Mohamed Farouk Allam

World Journal of Medical Microbiology 2022, 1(1), 25-29. DOI: 10.31586/wjmm.2022.479

Abstract Probiotics, prebiotics, and synbiotics modify various aspects of local and systemic immune function in multiple experimental models. However, their impact and mechanisms of action are not known across all products or noticed in every population studied, and impacts on in vitro, ex vivo, or other measures of immune function do not necessarily result in an impact on infection and illness in vivo [...] Read more.

Probiotics, prebiotics, and synbiotics modify various aspects of local and systemic immune function in multiple experimental models. However, their impact and mechanisms of action are not known across all products or noticed in every population studied, and impacts on in vitro, ex vivo, or other measures of immune function do not necessarily result in an impact on infection and illness in vivo. Studies have discussed that intestinal microbiota has an essential role in enhancing the immune system against viruses. The regulatory impact of the intestinal microbiota on viral infection is connected with local and systemic immune responses and plays a part in congenital and adaptive immune responses. The microbiota composition critically modulates the production of virus-specific CD4 and CD8 T cells and antibody responses following influenza virus infection. The intestinal microbiota has an important role in the stabilizing of immune homeostasis by augmenting the integrity of the barrier functions of the gut mucosa, which is a crucial aspect of systemic immunity. In conclusion, the intestinal microbiota can influence organismal immunity locally and systemically, proximally, and distally. Studying the possible mechanism by which the intestinal microbiota maintains host immunity can provide a clearer understanding of the occurrence and development of diseases.

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Essay

Open Access October 05, 2022

Blockchain Technology - A Algorithm for Drug Serialization

Madalsa Kumar

Universal Journal of Pharmacy and Pharmacology 2022, 1(1), 61-67. DOI: 10.31586/ujpp.2022.452

Abstract The Blockchain technology uses different type of database that transact data in blocks and then chained each data blocks. When data fills one block, it is chained the same data onto previous block therefore, all the data blocks are stored in chronological order. The blockchain technology can help to ensure that data in supply chain is reliable, accurate and can be shared with all stakeholders [...] Read more.

The Blockchain technology uses different type of database that transact data in blocks and then chained each data blocks. When data fills one block, it is chained the same data onto previous block therefore, all the data blocks are stored in chronological order. The blockchain technology can help to ensure that data in supply chain is reliable, accurate and can be shared with all stakeholders without any manipulation. It makes supply chain more transparent and end-to-end digital visibility of data source. Blockchain is stringent technology which fill the gap between stakeholders by providing transparent unmanipulated and truthful data in supply chain. There are many initiatives has been taken by multiple regulatory bodies with partnering with supply chain stakeholders including pharmaceutical manufacturer, distributors and dispensers. In USA, Food and Drug Administration’s regulatory body Drug Supply Chain Security Act (DSCSA) initi-ated pilot program in 2019 with the partnership of leading pharmaceuticals distributors to au-thenticating saleable returns to distributor from supply chain partners. DSCSA used MediLedger blockchain interoperable technology for process evaluation and it robustness for mitigating risk of drug counterfeiting possibilities in supply chain. The DSCSA found that pilot project was suc-cessful and results were astonishing. Later it was declared that blockchain technology can also be used for meeting DSCSA’s 2023 Act for unit level traceability.

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Review Article

Open Access September 28, 2022

5-Fluorouracil Ameliorates the Hematotoxicity Induced by Cyclophosphamide in Male Albino Rats

Rabia A M Yahya, Azab Elsayed Azab, Ahmed M. Attia, Mona A. Yehia, Karema El.M.Shkal

Universal Journal of Pharmacy and Pharmacology 2022, 1(1), 50-60. DOI: 10.31586/ujpp.2022.453

Abstract Background: Cyclophosphamide (CPA) is a drug with a wide spectrum of clinical uses. Its effectiveness in the treatment of cancer (acute and chronic leukemias, lymphoma, and multiple myeloma) and non-malignant diseases such as rheumatoid arthritis and vasculitis has been well established. Objectives: The present investigation aimed to study the effect of a sub-lethal dose of the [...] Read more.

Background: Cyclophosphamide (CPA) is a drug with a wide spectrum of clinical uses. Its effectiveness in the treatment of cancer (acute and chronic leukemias, lymphoma, and multiple myeloma) and non-malignant diseases such as rheumatoid arthritis and vasculitis has been well established. Objectives: The present investigation aimed to study the effect of a sub-lethal dose of the cyclophosphamide, 5-FU combination of 5-FU, and CPA on haematological parameters in the albino rats. Materials and Methods: Twenty-eight male adults were grouped randomly into four groups (n=5 in each group). Group I (control): Rats were injected with saline intraperitoneally at a dose of 1.0 ml/kg b.w. for 14 days. Group II cyclophosphamide (CPA): Cyclophosphamide at a dose of 10 mg/kg day by day through i.p. to rats for 14 days. Group III Fluorouracil (5-FU): 5-Fluorouracil at a dose of 10 mg/kg day by day in saline was given through i.p. to rats for 14 days. Group IV (CPA+5-FU): Rats were given CPA followed by 5-FU at a dose of 10 mg/kg per day (day by day) through i.p. to rats for 14 days. At the end of the experimental period, rats were anesthetized using light ether. Blood samples were taken for hematological evaluation. Results: White blood cells, hemoglobin content and red blood cell counts were significantly decline in rats treated with individual treatment with CPA and 5-FU in comparison to the control group, while the Combination antagonize the changes produced by CPA in hemoglobin and red blood cell counts. Intraperitoneal individual treatment with CPA and 5-FU in rats caused a significant reduction in the hematocrit and platelet. The reductions in these measured hematological parameters were also significantly and slightly ameliorated when the animals were given a combination of CPA and 5-FU. Cyclophosphamide and 5-FU individually reduced lymphocytes, neutrophils, eosinophils, and monocytes; while the combination of CPA and 5-FU antagonized these changes compared to CPA treated group. Conclusion: It could be concluded that the treatment of mammals with chemotherapy is associated with the production of free radicals that lead to hazardous alterations in hematological parameters. However, 5-FU and CPA combination could produce a significant amelioration in most cases for these changes. Future work should consider combined chemotherapy regimens, as two or more mechanisms of action of chemotherapeutic drugs could be more powerful than one mechanism. Using cyclophosphamide and 5-fluorouracil in combination may reduce cyclophosphamide’s side effects when given individually.

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Article

Open Access August 25, 2022

Gastrointestinal Injuries Following the Acute and Chronic Alcohol Abuse: An Update

Mentor Karemani, Entela Basha, Gentian Vyshka

World Journal of Clinical Medicine Research 2022, 1(1), 14-17. DOI: 10.31586/wjcmr.2022.373

Abstract The deleterious health effects of ethanol abuse are widely known and a diversity of medical conditions appear with excessive consumption. Acute and chronic abuse have different clinical characteristics, although severe intoxications are rare among alcoholics of a long career, where the systemic complications will dominate the symptomatology. While the medical focus acutely will mostly stay on the [...] Read more.

The deleterious health effects of ethanol abuse are widely known and a diversity of medical conditions appear with excessive consumption. Acute and chronic abuse have different clinical characteristics, although severe intoxications are rare among alcoholics of a long career, where the systemic complications will dominate the symptomatology. While the medical focus acutely will mostly stay on the nervous and circulatory effects, gastrointestinal complications that will come up chronically (liver, pancreas, bowel dysfunction) need proper consideration. Ethanol will affect gastrointestinal functionality through a triple action, directly on the epithelial cell and the secretory activity, by altering the motility and in the long-term scope, through promoting carcinogenesis. Medical teams dealing with acute and chronic ethanol intoxication or abuse must be aware of the multiple effects it shows, and perform a prompt diagnosis as well as appropriate intervention.

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Communication

Open Access August 01, 2022

Impact of Stress and Burnout on Quality of Life of Pastors

Stephen Doh Fia, Charles Fosu-Ayarkwah, Bismarck Kusi

Universal Journal of Social Sciences and Humanities 2022, 2(3), 160-175. DOI: 10.31586/ujssh.2022.388

Abstract The purpose of the study was to investigate the impact of stress and burnout on the quality of life of pastors in Assemblies of God Church in the Ashanti Region, Ghana. A descriptive survey design was adopted for the study. A sample of 254 out of a population of 744 was used for the study using stratified and simple random sampling procedures. Data were collected using a questionnaire and analysed [...] Read more.

The purpose of the study was to investigate the impact of stress and burnout on the quality of life of pastors in Assemblies of God Church in the Ashanti Region, Ghana. A descriptive survey design was adopted for the study. A sample of 254 out of a population of 744 was used for the study using stratified and simple random sampling procedures. Data were collected using a questionnaire and analysed using means and standard deviations, linear multiple regression, independent samples t-test, and one-way Analysis of Variance. Results showed that the pastors often experienced stress and frustrations due to a lack of resources such as money and infrastructure, different roles competing for their attention (ministry and family), delays in reaching their ministry goals, and carrying out a lot of activities the same time. The study also found that the pastors felt emotionally drained by their work and felt burned out. The study revealed that the relationship between stress level and quality of life was statistically significant. Similarly, the relationship between burnout level and quality of life was statistically significant. It was recommended that the leadership of Assemblies of God Church, Ghana should organise intermittent workshops for their pastors in all their branches on how to cope with the emotional drains of pastoring.

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Article

Open Access July 22, 2022

DFT-Based Prediction of Anti-Leishmanial Activity of Carboxylates and Their Antimony(III) Complexes Against Five Leishmanial Strains

Vishnu Kumar Sahu, Neetu Chandra, Pratibha Singh

Online Journal of Microbiological Research 2022, 1(1), 17-24. DOI: 10.31586/ojmr.2022.360

Abstract Carboxylates and their antimony(III) complexes experimentally scanned earlier for anti-leishmanial activity (IC₅₀) against five leishmanial strains viz., L. major, L. major (Pak), L. tropica, L. mex mex, and L. donovani. These activities have been theoretically predicted by DFT method along with quantitative structure-activity relationship (QSAR) study. Molecular modeling and geometry optimization of the all the eight compounds have been performed on workspace program of CAChe Pro software of Fujitsu by opting B88-PW91 (Becke '88; Perdew & Wang '91) GGA (generalized-gradient approximation) energy functional with DZVP (double-zeta valence polarized ) basis set in DFT (Density Functional Theory). For QSAR, multiple linear regression (MLR) analysis has been performed on Project Leader Program associated with CAChe. The reliability of correlation between experimental activities and predicted activities are r²= 0.826, r²_CV= 0.426 (L. major); r²= 0.905, r²_CV= 0.507 (L. major (Pak)); r²= 0.980, r²_CV= 0.932 (L. tropica); r²= 0.781, r²_CV= 0.580 (L. mex mex) and r²= 0.634, r²_CV= 0.376 (L. donovani [...] Read more.

Carboxylates and their antimony(III) complexes experimentally scanned earlier for anti-leishmanial activity (IC₅₀) against five leishmanial strains viz., L. major, L. major (Pak), L. tropica, L. mex mex, and L. donovani. These activities have been theoretically predicted by DFT method along with quantitative structure-activity relationship (QSAR) study. Molecular modeling and geometry optimization of the all the eight compounds have been performed on workspace program of CAChe Pro software of Fujitsu by opting B88-PW91 (Becke '88; Perdew & Wang '91) GGA (generalized-gradient approximation) energy functional with DZVP (double-zeta valence polarized ) basis set in DFT (Density Functional Theory). For QSAR, multiple linear regression (MLR) analysis has been performed on Project Leader Program associated with CAChe. The reliability of correlation between experimental activities and predicted activities are r²= 0.826, r²_CV= 0.426 (L. major); r²= 0.905, r²_CV= 0.507 (L. major (Pak)); r²= 0.980, r²_CV= 0.932 (L. tropica); r²= 0.781, r²_CV= 0.580 (L. mex mex) and r²= 0.634, r²_CV= 0.376 (L. donovani), and a comparison of the experimental values and the values obtained by theoretical calculations has been presented pictorially that shows close resemblance.

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Article

Open Access June 13, 2022

Studies on System Identification of Multiple Input Multiple Output (MIMO) Water Tank

Kirubanandan Shanmugam

International Journal of Mathematical, Engineering, Biological and Applied Computing 2022, 1(1), 30-39. DOI: 10.31586/ijmebac.2022.323

Abstract In this study, the system identification of a multiple input multiple-output (MIMO) water tank has been investigated. The given experimental system is a first-order system. Its transfer function was evaluated and the time constant was predicted. Once the parameters of the transfer functions (delay, gain, and time constant) were determined for each step input. This model each of the step responses [...] Read more.

In this study, the system identification of a multiple input multiple-output (MIMO) water tank has been investigated. The given experimental system is a first-order system. Its transfer function was evaluated and the time constant was predicted. Once the parameters of the transfer functions (delay, gain, and time constant) were determined for each step input. This model each of the step responses using MatLab’s Simulink. These simulated responses were then compared to the observed experimental responses.

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Technical Note

Open Access April 17, 2022

Dominant Parenting Style of Parents in Aowin Municipality in the Western North Region of Ghana

Joseph Mfum Appiah

Open Journal of Educational Research 2022, 2(2), 70-81. DOI: 10.31586/ojer.2022.239

Abstract The aim of the research was to examine the influence of parenting styles on academic performance of students in Aowin Municipality in the Western North Region of Ghana. Descriptive survey design was employed to collect quantitative data from the respondents. The study targeted all final year public junior high school students in the Aowin Municipality. A multi-stage sampling technique which [...] Read more.

The aim of the research was to examine the influence of parenting styles on academic performance of students in Aowin Municipality in the Western North Region of Ghana. Descriptive survey design was employed to collect quantitative data from the respondents. The study targeted all final year public junior high school students in the Aowin Municipality. A multi-stage sampling technique which involved the use of probability sampling techniques was employed to select 252 respondents with 142 boys and 110 girls. The main data collection instrument was questionnaire with 46 items. Document analysis was also performed on the pupils’ end of term examination results. Means, standard deviation, multiple regression, Pearson’s Product Moment Correlation and Chi-square were employed to analyse the data. The results revealed that authoritative parenting style dominates in parents of the JHS students in the municipality. The study concluded that, Authoritative parenting style predominates in JHS students in the Aowin municipality. There was a correlation between the parenting style of parents and the academic performance of JHS students. It was seen that, student coming from the authoritative parenting style had high performance than those coming from the authoritarian, permissive and neglectful parenting style. Students from neglectful parenting homes demonstrated low performance in school. It is recommended that policies should be developed by Ministry of Education to encourage parents to adopt appropriate parenting styles like the authoritative parenting style which has been revealed by this study as related to good academic performance. Management of various schools should collaborate with Parent-Teacher Association to organize seminars and workshops to educate parents on the influences of the various parenting styles on their children academic performance. This will enlighten parents on employing effective parenting style like authoritative parenting style that has been revealed by this study to correlates with high academic performance.

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Article

Open Access March 21, 2022

Ancient and modern grains, effects on human health: A first short review

Enrico V. Perrino

Research Journal of Ecology and Environmental Sciences 2022, 2(1), 21-25. DOI: 10.31586/rjees.2022.225

Abstract A short review concerning the distinction between ancient and modern grains or ancient and modern varieties of wheat, cereals and pseudocereals, along with their quality related mainly to human health and that of the environment is provided. Modern plant breeding, especially that started before the Green Revolution, based mainly on gross selection and very few crosses among local varieties/populations may be considered ancient grains, while those obtained after the Green revolution, based on intensive and multiple crosses among local and foreign varieties, including those obtained by induced mutation, may be considered modern grains. According to recent researches, it seems that ancient grains are healthier than the modern ones. The former would also have a lower environmental and agricultural impact than the latter. Since the picture on this topic is not yet clear I was asked to throw on it more light. In fact, most of researchers in the field do not understand difference among ancient and modern varieties. Thus, the objective of this short paper was to clarify and stimulate more research, possibly with a multidisciplinary approach. In Italy, for instance, there are ad hoc [...] Read more.

A short review concerning the distinction between ancient and modern grains or ancient and modern varieties of wheat, cereals and pseudocereals, along with their quality related mainly to human health and that of the environment is provided. Modern plant breeding, especially that started before the Green Revolution, based mainly on gross selection and very few crosses among local varieties/populations may be considered ancient grains, while those obtained after the Green revolution, based on intensive and multiple crosses among local and foreign varieties, including those obtained by induced mutation, may be considered modern grains. According to recent researches, it seems that ancient grains are healthier than the modern ones. The former would also have a lower environmental and agricultural impact than the latter. Since the picture on this topic is not yet clear I was asked to throw on it more light. In fact, most of researchers in the field do not understand difference among ancient and modern varieties. Thus, the objective of this short paper was to clarify and stimulate more research, possibly with a multidisciplinary approach. In Italy, for instance, there are ad hoc research projects that should be more adequately financed and supported, during their development. To make it easy, I have mentioned and listed more than thirty references.

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Review Article

Open Access February 22, 2022

Narcissism and Self-Esteem as Correlates of Secondary School Students’ Mathematics Academic Achievement in Anambra State

Adeline N. Anyanwu, Ngozi E. Ezenwosu, Kingsley E. Emesi, Lydia I. Eleje

Open Journal of Educational Research 2022, 2(1), 13-22. DOI: 10.31586/ojer.2022.200

Abstract The impact of narcissism and self-esteem on academic achievement has long been an important issue in developmental research. The study aimed to explore the students’ narcissism and self-esteem as correlates of academic achievement in Mathematics in Anambra State. Five research questions and five null hypotheses guided the study. The study adopted a correlational approach. The population of the [...] Read more.

The impact of narcissism and self-esteem on academic achievement has long been an important issue in developmental research. The study aimed to explore the students’ narcissism and self-esteem as correlates of academic achievement in Mathematics in Anambra State. Five research questions and five null hypotheses guided the study. The study adopted a correlational approach. The population of the study comprised of 21204 SS2 students from which a sample of 630 was drawn. Multi-stage procedure was used to select the sample. Two standardized research instruments namely; Narcissistic Personality Inventory (NPI), and Self-esteem Questionnaire (SQ), as well as score from students’ promotional examination were used for data collection. Cronbach’s alpha was used to determine the reliability of the items in the instruments. The overall reliability coefficient was 0.75 which shows that the instrument was reliable and good for the study. The Pearson Product Moment Correlation was used to answer research questions 1 to 4 and to test hypotheses 1 to 4, while the research question 5 and hypothesis 5 were answered and tested with multiple correlations. The findings showed that students’ power narcissism recorded a very low positive relationship with academic achievement in mathematics. Findings also revealed that the multiple correlation of these variables is positively non significant with academic achievement in mathematics. Based on these findings, it was recommended that as narcissistic individuals believe strongly that they are better than others, teachers and counsellors should develop a strategy to enhance the confidence and ability in the students as these will help them to become life long learning individuals thereafter.

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Article

Open Access December 16, 2021

Role of Colchicine in Management of COVID-19?

Kholoud Mohamed Elawady Elhefnawy Elshiwy, Ghada Essam El-Din Amin, Mohamed Nazmy, Rasha Samir, Mohamed Farouk Allam

Global Journal of Epidemiology and Infectious Disease 2022, 2(1), 1-3. DOI: 10.31586/gjeid.2022.177

Abstract CoV-2 disease 2019 (COVID-19) pandemic has exerted a great burden on the health and economic systems worldwide. One of the most important factors that affect the severity and prognosis of COVID-19 is the occurrence of hyperstimulation of the immune system resulting in “cytokine storm”. Similar to SARS-CoV, an intracellular complex called nod like receptor family pyrin domain containing 3 (NLRP3) [...] Read more.

CoV-2 disease 2019 (COVID-19) pandemic has exerted a great burden on the health and economic systems worldwide. One of the most important factors that affect the severity and prognosis of COVID-19 is the occurrence of hyperstimulation of the immune system resulting in “cytokine storm”. Similar to SARS-CoV, an intracellular complex called nod like receptor family pyrin domain containing 3 (NLRP3) inflammasome was found to be activated by SARS-CoV-2, then in turn stimulates several interleukins and initiates the inflammatory cascade. In addition, other inflammatory mediators such as interferons e.g., IFN-α, and IFN-γ, interleukins e.g., IL-1β, IL-12, IL-18, tumor necrosis factor-α (TNF- α), and chemokines e.g., CCL2, CXCL10 have been reported in severely ill patients. These mediators represent the corner stone in developing cytokine storm that results in uncontrolled systemic inflammatory reaction with subsequent acute respiratory distress syndrome (ARDS), multiple organ failure and eventually death. Based on its anti-inflammatory effects, colchicine has also gained attention to be utilized in the management of COVID-19 patient. Colchicine exerts its anti-inflammatory effect through inhibition of formation of microtubules which is considered an essential step in several cellular processes such as division, signalling, and migration. Also, colchicine affects the cytokine cascade by inhibiting IL-1β leading to reduction in neutrophils recruitment, free radicles production and inflammasome stimulation. This raises the concerns about the effectiveness of colchicine in COVID-19 treatment and the possibility of providing an improvement of the clinical course of the disease.

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Mini Review

Open Access November 02, 2023

Revealing Complexity: Confronting Challenges in the Pharmaceutical API Supply Chain

Manas Gorani

Universal Journal of Pharmacy and Pharmacology 2023, 2(1), 54-59. DOI: 10.31586/ujpp.2023.1193

Abstract The pharmaceutical industry relies extensively on Active Pharmaceutical Ingredients (APIs) as essential components in the production of drugs. The supply chain supporting these APIs is complex, encompassing multiple stages from raw material sourcing to distribution to pharmaceutical manufacturers worldwide. This manuscript explores the intricate challenges encountered within the pharmaceutical API [...] Read more.

The pharmaceutical industry relies extensively on Active Pharmaceutical Ingredients (APIs) as essential components in the production of drugs. The supply chain supporting these APIs is complex, encompassing multiple stages from raw material sourcing to distribution to pharmaceutical manufacturers worldwide. This manuscript explores the intricate challenges encountered within the pharmaceutical API supply chain, focusing on regulatory compliance, quality control, supply chain disruptions, and global dependencies. Regulatory compliance poses a significant hurdle, with varying standards across regions necessitating meticulous adherence to ensure market access and product safety. Quality control and assurance are paramount to maintaining consistency and purity in APIs, yet they present ongoing challenges such as batch variability and contamination risks. Supply chain disruptions, ranging from natural disasters to geopolitical tensions, highlight vulnerabilities in global sourcing strategies, underscoring the need for resilient supply chain management practices. Global dependencies on a limited number of suppliers or regions expose the industry to supply shortages and pricing pressures, exacerbated by geopolitical events and trade policies. These dependencies necessitate strategic diversification and risk mitigation efforts to ensure continuity in API availability and affordability. By addressing these challenges collaboratively, stakeholders can enhance the resilience and reliability of the pharmaceutical API supply chain, thereby ensuring uninterrupted access to essential medications and improving global healthcare outcomes.

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Review Article

Open Access December 27, 2023

Ensuring High Availability and Resiliency in Global Deployments: Leveraging Multi-Region Architectures, Auto Scaling, and Traffic Management in Azure and AWS

Manogna Dolu Surabhi

Journal of Artificial Intelligence and Big Data 2023, 3(1), 46-55. DOI: 10.31586/jaibd.2023.1208

Abstract Modern organizations leverage highly distributed, global deployments to provide high availability and resiliency for cloud-first applications. By hosting these applications across multiple geographic locations and relying on highly available services, organizations can prevent disruption to their business and reduce complexity by employing the scale of infrastructure offered by major cloud [...] Read more.

Modern organizations leverage highly distributed, global deployments to provide high availability and resiliency for cloud-first applications. By hosting these applications across multiple geographic locations and relying on highly available services, organizations can prevent disruption to their business and reduce complexity by employing the scale of infrastructure offered by major cloud providers. Global deployments in the cloud are built on well-known models such as failover, load balancing, and scalability. However, traditional methods used to recover from regional failure—while effective—can be complex. Typical multi-region recovery and high availability system architectures have latency and cost risks that should be considered when facing other limitations such as deployment models in the cloud. This document describes the different traffic management techniques that can be applied to multi-region strategies, focusing on trade-offs and costs. The introduction of new traffic management techniques being applied to the traditional global architectures now allows organizations to adopt cloud services more efficiently. Traffic management is much more straightforward in some environments, while others have started to leverage their traffic management platform via routing. In multi-region deployments, active-active and active-passive are the most common architectural models, allowing organizations to seamlessly handle failover, scalability, and global distribution based on business goals and requirements. However, traffic management for these infrastructures is critical to ensure just data distribution and efficiency, maintaining costs under control and workloads rerouted when necessary. Using the new traffic management techniques will allow organizations to evolve system architectures easily based on business requirements, taking advantage of cost benefits from multiple infrastructures. In these scenarios, traffic management becomes a crucial backbone of success to ensure that traffic is being efficiently and intelligently distributed [1].

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Review Article

Open Access January 10, 2022

Composable Infrastructure: Towards Dynamic Resource Allocation in Multi-Cloud Environments

Ravi Kumar Vankayalapati, Andrew Edward, Zakera Yasmeen

Universal Journal of Computer Sciences and Communications 2022, 1(1), 1-15. DOI: 10.31586/ujcsc.2022.1222

Abstract To ensure maximum flexibility, service providers offer a variety of computing options with regard to CPU, memory capacity, and network bandwidth. At the same time, the efficient operation of current cloud applications requires an infrastructure that can adjust its configuration continuously across multiple dimensions, which are generally not statically predefined. Our research shows that these [...] Read more.

To ensure maximum flexibility, service providers offer a variety of computing options with regard to CPU, memory capacity, and network bandwidth. At the same time, the efficient operation of current cloud applications requires an infrastructure that can adjust its configuration continuously across multiple dimensions, which are generally not statically predefined. Our research shows that these requirements are hardly met with today's typical public cloud and management approaches. To provide such a highly dynamic and flexible execution environment, we propose the application-driven autonomic management of data center resources as the core vision for the development of a future cloud infrastructure. As part of this vision and the required gradual progress toward it, we present the concept of composable infrastructure and its impact on resource allocation for multi-cloud environments. We introduce relevant techniques for optimizing resource allocation strategies and indicate future research opportunities [1]. Many cloud service providers offer computing instances that can be configured with arbitrary capacity, depending on the availability of certain hardware resources. This level of configurability provides customers with the desired flexibility for executing their applications. Because of the large number of such prerequisite instances with often varying characteristics, service consumers must invest considerable effort to set up or reconfigure elaborate resource provisioning systems. Most importantly, they must differentiate the loads to be distributed between jobs that need to be executed versus placeholder jobs, i.e., jobs that trigger the automatic elasticity functionality responsible for resource allocator reconfiguration. Operations research reveals that the optimization of resource allocator reconfiguration strategies is a fundamentally difficult problem due to its NP-hardness. Despite these challenges, dynamic resource allocation in multi-clouds is becoming increasingly important since modern Internet-based service settings are dispersed across multiple providers [2].

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Review Article

Open Access December 27, 2019

The Role of Neural Networks in Advancing Wearable Healthcare Technology Analytics

Zakera Yasmeen

Journal of Artificial Intelligence and Big Data 2019, 1(1), 1-12. DOI: 10.31586/jaibd.2019.1251

Abstract Neural networks are bringing a transformation in wearable healthcare technology analytics. These networks are able to analyze a vast amount of data to help in making decisions concerning patient care. Advancements in deep learning have brought neural networks to the forefront, making data analytics a straightforward process. This study will help in unveiling the use of ICT and AI in medical [...] Read more.

Neural networks are bringing a transformation in wearable healthcare technology analytics. These networks are able to analyze a vast amount of data to help in making decisions concerning patient care. Advancements in deep learning have brought neural networks to the forefront, making data analytics a straightforward process. This study will help in unveiling the use of ICT and AI in medical healthcare technology, crawling through some industry giants. Wearable Healthcare Technologies are becoming more popular every day. These technologies facilitate collecting, monitoring, and sharing every vital aspect of the human body necessary for diagnosing and treating an ailment. At the advent of global digitization, health data storage and systematic analysis are taking shape to ensure better diagnostics, preventive, and predictive healthcare. Healthcare analytics powered by neural networks can significantly improve health outcomes, maximizing individuals' potential and quality of life. The breadth and possibilities of connected devices are getting wider. From personal activity monitoring to quantifying every bit of health statistics, connected devices are making an impact in measurement, management, and manipulation. In healthcare, early diagnosis could be a lifesaver. Data analytics can help in a big way to make moves and predictions to save lives. We are in another phase of the digitization era, "Neural Network and Wearable Healthcare Technology Analytics." A neural network could be conceived as an adaptive system made up of a large number of neurons connected in multiple layers. A neural network processes data in a similar way as the human brain does. Using a collection of algorithms, for many neural networks, objects are composed of 'input' and 'output' layers along with the layers of the neural network.

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Review Article

Open Access December 27, 2019

Revolutionizing Patient Care and Digital Infrastructure: Integrating Cloud Computing and Advanced Data Engineering for Industry Innovation

Tulasi Naga Subhash Polineni, Venkata Krishna Azith Teja Ganti

World Journal of Clinical Medicine Research 2019, 1(1), 1-16. DOI: 10.31586/wjcmr.2019.1252

Abstract This work details how the integration of cloud computing and advanced data engineering can innovate and reshape patient care and digital infrastructure. In the healthcare sector, cloud services offer the necessary support to generate digitally-oriented services and service kits. These services can contain high levels of availability, low levels of latency, and on-demand scaling capabilities, while [...] Read more.

This work details how the integration of cloud computing and advanced data engineering can innovate and reshape patient care and digital infrastructure. In the healthcare sector, cloud services offer the necessary support to generate digitally-oriented services and service kits. These services can contain high levels of availability, low levels of latency, and on-demand scaling capabilities, while following the strictest data protection laws and regulations. On the other hand, these services can be combined with data engineering techniques to construct an ecosystem that enhances and adds an optimized data layer on any cloud environment. This ecosystem includes technologies to acquire, process, and manage healthcare data while respecting all regulatory obligations and institutions and can be part of a comprehensive digitalization strategy. The objective is to augment the healthcare services that the industry offers by leveraging healthcare data and AI technologies. Designed services, processes, and technologies can be described either as industry-agnostic services or healthcare-specific services that process and manage electronic healthcare records (EHR). Industry-agnostic services offer a set of tools and methodologies to conduct optimized data experiments. The goal is to exploit any variety, velocity, volume, and veracity of medical data. Healthcare-specific services offer a set of tools and methodologies to connect to any common EHR vendor in a privacy-preserving manner. Participating companies are thus able to hold, share, and make use of healthcare data in real-time. The proposed architecture can be transformative for the healthcare industry, opening up and facilitating experimentation on new and scalable service models. The transition to a more digital health approach would help overcome the limits encountered in traditional settings. Limitations in the availability of healthcare facilities and healthcare professionals have underpinned the increasing share of telemedicine in the care process. However, the record-keeping of the patients that undergo care outside of traditional healthcare facilities is often missing and can severely influence the continuity of treatment. Identifying new methods to implement disease prevention and early intervention processes is crucial to avoid more extensive treatment and to support those on multiple line therapies. For chronic patients, having a service available that monitors the state of health and intervenes when parameters go off the wanted range is crucial. However, the same patients are the most under the influence of the decision of care providers; a second opinion might be given remotely which the patient can access at any time on-demand. To address these different kinds of services, an ecosystem composed of a dictionary's worth data layer is outlined, able to live and operate seamlessly in any cloud environment. This future work's envisioned outcome is the rapid evolution and re-definition of the European healthcare landscape.

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Review Article

Open Access December 26, 2021

Architectural Frameworks for Large-Scale Electronic Health Record Data Platforms

Sasi Kumar Kolla

Current Research in Public Health 2021, 1(1), 1-19. DOI: 10.31586/crph.2021.1372

Abstract Architectural frameworks for large-scale Electronic Health Record (EHR) data platforms are described. Existing EHR data platform architectures often leverage multiple cloud-based solutions blended with institutional infrastructures to manage and analyze clinical data at scale. Key design principles governing the scale of existing EHR data architecture include model design, governance structure, [...] Read more.

Architectural frameworks for large-scale Electronic Health Record (EHR) data platforms are described. Existing EHR data platform architectures often leverage multiple cloud-based solutions blended with institutional infrastructures to manage and analyze clinical data at scale. Key design principles governing the scale of existing EHR data architecture include model design, governance structure, data access management, data security/policy/protection, data-information-language-based standardization, and analytics tool alignment, among others. The rapidly evolving technology landscape and the unprecedented volume of incident and retrospective clinical data being collected and generated within healthcare organizations have led to the emergent need for a dedicated architectural framework to support large-scale computing in the health informatics domain. The application areas of large-scale computing in health informatics include real-time predictive analytics, risk stratification, patient cohort analytics, development of predictive models for specific institutions or population groups, and many more. The use of EHR data for a multitude of decision-making processes in both clinical and non-clinical settings has prompted the establishment of policies prescribing the conditions of access and use of EHR data for non-employed individuals in the organization. Consequently, the demand for accessing, using, and managing EHR data at scale has impacted the over.

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Review Article

Open Access June 28, 2016

Scalable Task Scheduling in Cloud Computing Environments Using Swarm Intelligence-Based Optimization Algorithms

Srinivas Chippagiri, Savan Kumar, Sumit Kumar

Journal of Artificial Intelligence and Big Data 2021, 1(1), 1-10. DOI: 10.31586/jaibd.2016.1291

Abstract Effective task scheduling in cloud computing is crucial for optimizing system performance and resource utilization. Traditional scheduling methods often struggle to adapt to the dynamic and complex nature of cloud environments, where workloads, resource availability, and task requirements constantly change. Swarm intelligence-based optimization algorithms, such as Particle Swarm Optimization [...] Read more.

Effective task scheduling in cloud computing is crucial for optimizing system performance and resource utilization. Traditional scheduling methods often struggle to adapt to the dynamic and complex nature of cloud environments, where workloads, resource availability, and task requirements constantly change. Swarm intelligence-based optimization algorithms, such as Particle Swarm Optimization (PSO), Ant Colony Optimization (ACO), and Artificial Bee Colony (ABC), offer a promising solution by mimicking natural processes to explore large search spaces efficiently. These algorithms are effective in balancing multiple objectives, including minimizing execution time, reducing energy consumption, and ensuring fairness in resource allocation. They also enhance system scalability, which is vital for modern cloud infrastructures. However, challenges remain, including slow convergence speeds, complex parameter tuning, and integration with existing cloud frameworks. Addressing these issues will be essential for the practical implementation of swarm intelligence in cloud task scheduling, helping to improve resource management and overall system performance.

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