This article presents a mathematical model designed to simulate the impact of targeted interventions aimed at preventing HIV transmission among female sex workers (FSWs) and their clients, while also analyzing their effects on the health of the general population. The compartmental model distinguishes between high-risk populations (FSWs and their clients) and low-risk populations (sexually active men and women in the general population), and links prevention efforts in high-risk groups to the evolution of the epidemic in the low-risk population. The fundamental properties of the model, such as the positivity of solutions and the boundedness of the system, have been verified, and the basic reproduction number R₀ has been calculated. Finally, the stability of the model was studied using Varga’s theorem and the Lyapunov method. Simulation results show that targeted prevention among FSWs and their clients reduces HIV incidence in the general population. This framework provides a valuable tool for guiding policymakers in the design of effective strategies to combat the epidemic, especially relevant in the context of suspension of USAID funding.

Opuntia ficus-indica (L.) Mill., commonly known as prickly pear, is a versatile plant widely used for food, medicinal, and cosmetic purposes in various regions of the Mediterranean and North Africa. This study provides a comparative ethnobotanical review of prickly pear uses in Algeria, Morocco, Tunisia, and Italy. In total, 74 articles were selected from ethnobotanical uses in Italy, Algeria, Morocco and Tunisia. In the Maghreb, the plant is used for fruit production and processed products, such as jams, oils, and flours, as well as for traditional medicinal purposes. In Algeria and Morocco, the fruits and cladodes are used to treat digestive disorders, diabetes, and skin diseases. In Tunisia, products derived from O. ficus-indica are also applied in the cosmetic industry and for erosion control. In Italy, particularly in Sicily and Calabria, the prickly pear is a vital resource, used for both food consumption and for medicinal purposes. The cladodes, rich in mucilage, are applied as topical remedies for skin problems, while the fruits are a key ingredient in the preparation of traditional desserts. Furthermore, O. ficus-indica has historically been used as forage and to produce natural dyes. Results indicate that the versatility of this species, combined with its ability to adapt to extreme climates, makes it a valuable resource for the development of new nutraceutical and cosmetic products. However, further scientific research is necessary to explore the bio-functional potential of this plant and to promote its broader and more sustainable use, especially in arid and semi-arid regions.

A regular menstrual cycle is important to maintain a woman’s fertility. This cycle has been linked to optimal function of the thyroid gland in the production of its hormones. Disturbance of thyroid gland functions could result to female infertility due to changes in menstrual patterns. Aim of this research was to determine the correlation between thyroid gland functions and menstrual patterns amongst infertile and fertile women attending a tertiary care hospital in North-Central Nigeria. This comparative, cross-sectional study recruited 106 women who visited the hospital's Gynecology Clinic and Family Planning Clinic. 53 of the 106 patients were women with a history suggestive of either primary or secondary infertility and the remaining 53 women with no history of infertility served as the control. A well-structured questionnaire was used to obtain data on the patients’ menstrual patterns. Anthropometric data were measured and obtained. Collected blood samples were analyzed using Enzyme-Linked Immunosorbent Assay (ELISA) technique to determine the serum levels of thyroid hormones. All obtained data was analyzed, and the level of significance was set at p<0.05, at a 95% confidence interval. 33 patients had menstrual anomalies (78.8% infertile women; 21.2% fertile women who served as control, p=0.012). The incidence of menstrual anomalies in the infertile women group and control group was 7.5% versus 0.0% for amenorrhea; 20.8% versus 5.7% for menorrhagia; 9.4% versus 7.5% for oligomenorrhea; 7.5% versus 0.0% for hypomenorrhea; nil polymenorrhea for both groups; and 50.9% versus 86.8% for normal menstrual patterns. Ten (9.43%) patients were diagnosed with thyroid dysfunctions (80% in infertile group; 20% in control group, p=0.046). Six (18.2%) out of 33 women with menstrual anomalies were diagnosed with thyroid dysfunction. Five (83.3%) out of these 6 women with both menstrual anomalies and diagnosed thyroid dysfunction were infertile while only one (16.7%) was fertile. Thyroid gland dysfunction correlates strongly with abnormal menstrual patterns, which implies that it is vital to evaluate thyroid hormone levels in blood serum in the course of treating menstrual irregularities and female infertility. Early detection of thyroid dysfunction is important in achieving a positive treatment outcome for female infertility.

Studies on the use of pesticides in southwest Nigeria have revealed a substantial rise in a variety of pesticide-related illnesses, including mental impairment and reproductive problems. Those who work in agriculture and are regularly exposed to pesticides are the most impacted. The World Health Organization (WHO) predicts that three million severe pesticide poisoning episodes occur globally each year, with at least 300.000 deaths and 99% of cases occurring in low- and middle-income nations. The effects of longer-term exposure to pesticides on health are not yet precisely estimated. Objectives: To this end, the objective of this study is to assess the knowledge of pesticide residues and common pesticides in grain-based food (brown and white beans, yellow and white maize, brown millet and rice) about pesticide use in selected markets of Southwest Nigeria. Methods: A total of 240 respondents were selected from four states (Ado-Ekiti, Ibadan, Osun and Ondo) with the aid of structured questionnaire and interview guide using purposive sampling technique. The markets were Oja-titun (market) Ile-Ife, Osun; Alesinloye Market Ibadan, Oyo; Oja Oba, Ado-Ekiti, Ekiti; and Oja Oba, Akure Ondo State. The identification and quantification of pesticide residues was done using a Varian 3800/4000 gas chromatograph mass spectrometer while 60 structured questionnaires were administered to respondents including food merchants, buyers/consumers as well as food vendors. Data were analysed using descriptive statistics. Results: The experiment was conducted from November 2020 to November 2021. Up to 50.4% never read instructions on pesticide application while a shared 24.8% read them always and occasionally. The number of respondents who never read the instructions were particularly high in Ekiti and Ondo, up to 52.5% of the respondents in Ekiti do not know whether or not they are exposed to pesticides during application. Also, majority of the respondents never attended any professional training on pesticide application, this amounted to 79.3%. Most people were not aware that unsafe pesticide application is harmful to human health. Similarly, a wide variety of symptoms were reported by respondents following pesticide application or consumption of grains, these included headaches and dizziness, itching and redness of the eyes, skin allergy, diarrhea, and stomach disorder, vomiting and loss of appetite, weakness of the body, asthma, permanent skin patches, shortness of breath, excessive sweating. Millet recorded the highest number of OCP residues while maize had the lowest. On the contrary, maize had the highest number of OPP and carbamate residues while millet had the lowest number of OPP residues. Meanwhile, maize, rice and beans had only one carbamate pesticide residue. Conclusions: According to the study's conclusions, farmers who can only get information from agricultural extension officials should receive urgent and immediate attention for raising awareness. Additionally, extensive IPM training programs must be created with the intention of disseminating precautions for protecting human health and a healthy agro-ecosystem. In order to find more effective pest management methods that utilize less pesticides, it is crucial to reevaluate the pesticide residues and common pesticides found in grains in the targeted markets. To reduce farmers' exposure to pesticides, it is also required to establish personal protective measures, special educational initiatives, and legislation promoting the use of safer pesticides. Significance and novelty: This study gives policymakers a comprehensive understanding of the ways that may be utilized to close the significant knowledge gap on pesticide residues in grains and provides an insight into the knowledge of pesticide residues and common pesticides in grains.

Background: Shiga toxin producing Escherichia coli (STEC) inducing hemolytic uremic syndrome (HUS) with multiple organ involvement is associated with significant morbidity and mortality. The treatment has mostly been focused on kidney, respiratory and cardiovascular supports and not against the bacteria that cause STEC-HUS. The use of bactericidal therapy has been shown to be antibiotic dependent and certain antibiotics inhibit the production and release of Shiga toxin, eradicate STEC without harmful effects, and improve outcome. Methods: A previously healthy 18-months-old girl with STEC causing severe colitis, kidney failure and multi-organ dysfunction was treated with antibiotics that were known to inhibit the release of Shiga toxin as a supplement to supportive care. Results: The antibiotic regime stopped the pathophysiological process with prompt clinical improvement in association with the disappearance of the Shiga toxins. Conclusions: The present case report fortifies and recommends appropriate antibiotic treatment during STEC-HUS, suggesting clinicians to consider the use of these in severe STEC-HUS as early as possible.

The study investigates the use of Recycled Polystyrene (RP) in the production of particleboard. Boards of 6mm thickness with dimension of 350 mm x 350 mm were produced from mixture of Cocos nucifera stem particles and RP. The boards were made at varying mixing ratio of 1:1, 2:1, and 3:1 and board densities of 1000 kg/m3 1100 kg/m3 and 1200 kg/m3. Thickness swelling (TS), Water Absorption (WA), Modulus of Rupture, and Modulus of Elasticity of the boards were evaluated in accordance to ASTM D-1037 standard. Data obtained were subjected to analysis of variance (ANOVA) at 5% probability level. TS and WA decreases as the mixing ratio increases from 1:1 to 3:1 and board density increases from 1000 kg/m3 to 1200 kg/m3. Also, MOR and MOE of boards increase as the board density was increased from 1000 kg/m3 to 1200 kg/m3. However, MOR and MOE of boards initially increase as mixing ratio increases from 1:1 to 2:1 and later decreases with further increase in mixing ratio. The strongest and most dimensionally stable board was produced at board 1200 kg/m3 and mixing ratio 2:1. This study proves that RP is a good substitute for formaldehyde based resin commonly used in particle boards industries.

In order to evaluate the effect of Azospirillum brasilense and mycorrhizal fungi in the soil on the nutrition of the yacon crop (Smallanthus sonchifolius [(Poeppig & Endlicher) H. Robinson]), determinations of agronomic parameters and the health status of the plants were carried out, under greenhouse conditions. The tests were carried out at the time of the implantation of the culture: the propagules were inoculated with A. brasilense and with native mycorrhizal fungi, generating four treatments, including the control and the co-inoculation of the consortium of the microorganisms under study (T0: control or control without inoculation; T1: inoculation with native A. brasilense; T2: inoculation with native mycorrhizal fungi and T3: joint inoculation with A. brasilense and native mycorrhizal fungi. The results indicate that co-inoculation with A. brasilense and native mycorrhizal fungi increased plant growth in height, leaf area, biomass, dry matter and yields significantly in greenhouse production. It was determined that the application of the selected microorganisms has a plant growth promoting effect, increasing growth and productivity, greenhouse grown yacón.

Any history of science has its own geography as well. Geographers of science have tried to put science in its place. They study the socio-spatial settings in which scientific knowledge was generated, displayed and legitimated. For them, science is socially constructed in spatialities and temporalities. The main question should to be “how” spatialities are constructing scientific knowledge via its “causalities”. Geography of science is not just about special places, locations, and regions in which scientific knowledge is unequally produced/consumed and circulated or how the use of scientific knowledge can lead to the production and reproduction of unique places and spaces. Geography of science is also about a variety set of spatial causalities through which scientific knowledge can be formed and transformed. This also means that the innovative knowledge or ideas development takes place not only in the spatial contexts but because of the spatial causalities which rise from the myriad interlinkages and interdependencies among places. These imperatives of spatial significance operate across many spatial scales from the body to the global. Hence, in our increasingly glocalized world, we must seek knowledge in spatial encounters and betweenness of places, not merely within spaces and places.

This study addresses the critical challenge of material scarcity within Ghana’s creative industries by pioneering the synthesis of professional-grade stage blood from indigenous, locally-sourced materials. In the context of Ghanaian theatre and film, practitioners face significant barriers due to the high cost and limited availability of imported special effects products, often resulting in the use of inadequate substitutes that compromise aesthetic realism, safety, and narrative authenticity. This paper responds by exploring the potential of cassava starch, tapioca, kenkey dough, and fufu wax. Grounded in Schumacher’s theory of Appropriate Technology, the paper reframes indigenous resources not as inferior alternatives but as technologically and contextually appropriate solutions that align with Ghana’s economic, environmental, and social realities. The study provides detailed, reproducible recipes for both flowing and clotted blood variants, validated through practical application in simulated special effects such as gunshot wounds and deep-tissue scars. These formulations meet key performance criteria: visual fidelity under theatrical and cinematic conditions, controlled viscosity, ease of application and removal, and performer safety. Beyond technical innovation, this research contributes to shifting academic and professional discourse from dependency and scarcity toward resourcefulness, sustainability, and artistic self-reliance. It offers a practical framework for reducing production costs, enhancing the quality of visual storytelling, and fostering local value chains within Ghana’s growing creative economy.

Mathematical modeling plays a central role in infectious disease epidemiology, shaping outbreak response strategies and informing public health policy. The COVID-19 pandemic demonstrated the value of these models but also exposed persistent limitations related to data fragility, lack of transparency, limited stakeholder engagement, and insufficient consideration of social and political contexts. Rather than critiquing modeling as a discipline, this perspective argues for a reorientation of infectious disease modeling toward a more responsive, equity-centered, and participatory paradigm. We propose a conceptual framework built on three interrelated principles: adaptability through real-time data integration, transparency via open-source and reproducible practices, and relevance through interdisciplinary and co-produced model design. Drawing on illustrative examples from COVID-19 and dengue control efforts, we highlight how integrating behavioral dynamics, local knowledge, and policy feedback can improve model usefulness and public trust. Reconceptualizing models as dynamic systems of inquiry rather than static forecasting tools can enhance decision-making and promote more equitable and effective responses to future public health emergencies.

The pharmaceutical industry is undergoing a profound transformation driven by advancements in Information Technology (IT), with Enterprise Resource Planning (ERP) systems playing a pivotal role in reshaping operations. These systems offer integrated solutions that streamline key business processes, such as production, inventory management, supply chain optimization, regulatory compliance, and data integration, contributing significantly to operational efficiency and organizational agility. This paper explores the evolution and impact of ERP systems within the pharmaceutical sector, highlighting their contributions to overcoming the industry’s inherent challenges, including complex regulatory requirements, the need for accurate and real-time data, and the demand for supply chain resilience. The integration of cloud-based ERP solutions, the incorporation of emerging technologies like Artificial Intelligence (AI), Machine Learning (ML), and the Internet of Things (IoT), and enhanced data analytics capabilities have revolutionized pharmaceutical IT. These advancements not only reduce operational costs, improve forecasting accuracy, and enhance collaboration but also ensure compliance with stringent global regulations, such as Good Manufacturing Practices (GMP) and FDA guidelines. Moreover, ERP systems have been instrumental in managing the pharmaceutical supply chain, ensuring product traceability, and improving inventory control and order fulfillment processes. This manuscript examines how ERP systems enable pharmaceutical companies to maintain high standards of product quality, improve decision-making, and ensure the safety and efficacy of drugs through robust tracking and auditing mechanisms. A case study of a pharmaceutical company that implemented an ERP system demonstrates the tangible benefits, including increased operational efficiency, improved compliance rates, and enhanced customer satisfaction. However, despite the clear advantages, challenges such as customization complexities, data integration issues, and resistance to change remain. As the pharmaceutical industry continues to evolve, ERP systems will remain a cornerstone of digital transformation, facilitating smarter decision-making, better resource management, and enhanced collaboration across global operations. This paper also identifies future trends, including the potential of AI and blockchain technologies in further strengthening ERP systems and transforming the pharmaceutical landscape.

The synthesis and optimization of Active Pharmaceutical Ingredients (APIs) is fundamental to pharmaceutical drug development, directly influencing drug efficacy, safety, and cost-effectiveness. Over recent years, significant advancements in synthetic methodologies and manufacturing technologies have transformed API production. This manuscript provides an overview of the latest innovations in API synthesis, focusing on key techniques such as green chemistry, continuous flow chemistry, biocatalysis, and automation. Green chemistry principles, including solvent substitution and catalytic reactions, have enhanced sustainability by reducing waste and energy consumption. Continuous flow chemistry offers improved reaction control, scalability, and safety, while biocatalysis provides an eco-friendly alternative for synthesizing complex and chiral APIs. Additionally, the integration of automation and advanced process control using machine learning and real-time monitoring has optimized production efficiency and consistency. The manuscript also discusses the challenges associated with regulatory compliance and quality assurance, highlighting the role of advanced analytical techniques such as HPLC, NMR, and mass spectrometry in ensuring API purity. Looking ahead, personalized medicine and smart manufacturing technologies, including blockchain for traceability, are expected to drive further innovation in API production. This review concludes by emphasizing the need for continued advancements in sustainability, efficiency, and scalability to meet the evolving demands of the pharmaceutical industry, ultimately enabling the development of safer, more effective, and environmentally responsible medicines.

Bead jewellery is common in all Ghanaian communities. Bead jewellers are well-known for their important bead jewellery production and have advanced to the Master craft level. The industry can be utilized if the industry's difficulties are discovered and remedied. The study area for the research includes Ghana's Eastern, Ashanti, and Greater Accra Regions. The study's population included bead jewellers, bead jewellery firms, bead dealers, bead aficionados, clients, and bead makers. With a sample size of 30, data was gathered mostly through direct observations, interviews, and document reviews. The study went over the procedure for securing land for a bead jewellery workshop. According to a survey conducted by the Ghanaian Chamber of Commerce and Industry (GCCII), Ghanaian bead jewellers should use qualified designers. Cost pooling in legal services, accounting, and consulting is likely to save money.

Pharmaceutical supply chains are critical to ensuring the availability of safe and effective medications, yet they face numerous challenges that can jeopardize public health. This article provides a comprehensive analysis of the key issues impacting pharmaceutical supply chains, including regulatory compliance, demand forecasting, supply chain visibility, quality assurance, and geopolitical risks. Regulatory compliance remains a significant concern due to the stringent guidelines imposed by authorities such as the FDA and EMA, which can lead to increased operational costs and time delays. Additionally, traditional demand forecasting methods often fail to accurately predict fluctuations in drug demand, resulting in stockouts or excess inventory. Limited supply chain visibility further complicates these challenges, hindering timely decision-making and operational efficiency. Quality assurance is paramount, as maintaining the integrity of pharmaceutical products throughout the supply chain is crucial to preventing costly recalls and ensuring patient safety. Moreover, the globalization of supply chains introduces vulnerabilities to geopolitical risks, trade disputes, and natural disasters. In response to these issues, this article outlines strategic recommendations for optimizing pharmaceutical supply chains. These include leveraging advanced analytics and IoT technologies to enhance demand forecasting and visibility, strengthening compliance through automated systems and training, fostering collaboration among stakeholders, implementing robust risk management frameworks, and investing in quality management systems. By adopting these strategies, pharmaceutical companies can enhance the efficiency and resilience of their supply chains, ultimately ensuring the continuous availability of essential medications for patients worldwide. This analysis serves as a critical resource for industry professionals seeking to navigate the complexities of pharmaceutical supply chains in an increasingly dynamic global environment.

Active Pharmaceutical Ingredients (APIs) serve as the cornerstone of pharmaceutical development, driving therapeutic efficacy and safety in drug formulations. This article provides a comprehensive overview of the lifecycle of APIs, starting from their discovery and development, through to manufacturing processes and regulatory oversight. The development of APIs begins with intensive research and discovery efforts, where medicinal chemists and pharmacologists identify and optimize potential compounds through computational modelling, high-throughput screening, and structure-activity relationship studies. Promising candidates undergo rigorous preclinical testing to assess pharmacological properties, safety profiles, and potential adverse effects in animal models. Upon successful preclinical outcomes, APIs progress to clinical trials, involving phases of testing in human subjects to evaluate efficacy, dosage regimens, and safety profiles under controlled conditions. Clinical trial data are meticulously analyzed to support regulatory submissions, demonstrating the API's therapeutic benefits and safety for eventual patient use. Manufacturing APIs involves complex chemical synthesis or biotechnological methods, ensuring precise control over reaction conditions, purity, and yield. The scale-up from laboratory synthesis to industrial production demands adherence to Good Manufacturing Practices (GMP), where stringent quality control measures verify consistency, potency, and stability throughout production batches. Regulatory oversight by authorities such as the Food and Drug Administration (FDA) in the United States and the European Medicines Agency (EMA) in Europe ensures that APIs meet stringent standards of safety, efficacy, and quality before market approval. Manufacturers must submit comprehensive Chemistry, Manufacturing, and Controls (CMC) data, detailing manufacturing processes, analytical methods, and stability studies to support regulatory filings.

Drug shortages represent a significant and growing challenge within the pharmaceutical supply chain, with profound implications for patient care, public health, and healthcare costs. This manuscript provides a comprehensive examination of the causes and impacts of drug shortages, highlighting the multifaceted nature of this issue. Key factors contributing to shortages include manufacturing complications, limited availability of active pharmaceutical ingredients (APIs), market dynamics that discourage the production of less profitable medications, and regulatory challenges that slow down the approval process for new manufacturing capacities. The consequences of these shortages are far-reaching. Patients often face treatment delays, which can lead to adverse health outcomes, increased hospitalization rates, and even mortality. Healthcare providers experience heightened operational costs as they seek alternative therapies and manage complications resulting from inadequate treatment. Furthermore, the frequent occurrence of drug shortages erodes public trust in both the healthcare system and the pharmaceutical industry, leading to decreased patient adherence to prescribed therapies. To mitigate the impacts of drug shortages, this manuscript proposes several strategic solutions, including enhanced communication among stakeholders, diversification of supply sources, increased regulatory flexibility, and collaborative approaches between public and private sectors. Additionally, raising awareness among healthcare providers and patients regarding the causes and potential alternatives can empower stakeholders to navigate shortages effectively. Ultimately, addressing drug shortages necessitates a proactive and coordinated effort from all participants in the pharmaceutical supply chain. By implementing these strategies, stakeholders can enhance the resilience of the supply chain, ensuring that essential medications remain accessible and that patient care is not compromised. The findings of this manuscript underscore the urgent need for ongoing vigilance and collaborative action to tackle the challenges posed by drug shortages, safeguarding public health and improving healthcare outcomes globally.

This study explores the integration of Adinkra symbols into the set design of Ghana’s Most Beautiful (GMB), a popular beauty pageant and reality TV show that has aired on TV3; a private television station in Ghana. GMB showcases beauty, intelligence, cultural knowledge, and traditional values, celebrating Ghana's rich cultural heritage through female contestants representing the country's diverse ethnic groups. In response to the lack of coherent Ghanaian artistic elements in previous set designs, this study employed an artistic methodology to incorporate four Adinkra symbols, Okɔdeɛ Mmɔwerɛ, Duafe, Dweninimmɛn, and Mate Masie, into the set design for the show’s eighth season. These symbols, signifying beauty, strength, wisdom, and unity respectively, were creatively integrated into a crown-like set design for the grand finale, harmonizing aesthetic trends with cultural significance. The design process was informed by rigorous research and stakeholder interviews, ensuring that the selected symbols conveyed the intended cultural messages. The results highlight the potential of traditional symbols to enhance both the cultural relevance and visual appeal of television productions. The project enriches the cultural depth of GMB production and offers a blueprint for incorporating indigenous symbols into contemporary set design. The study recommends that future productions continue exploring traditional symbols to deepen the appreciation of Ghanaian heritage and strengthen cultural identity through visual arts.

Tanga City is the region with several micro-and small-scale pasta processing companies in the country. Therefore, the purpose of this study was to assess the quality and safety of folded vermicelli produced by the small-scale processors in Tanzania. Samples of 1 kg folded vermicelli were collected from 14 processing companies, by the intentional cluster sampling technique. The samples were analysed for aflatoxin and microbiological (Escherichia coli, Aspergillus flavus, and Aspergillus parasiticus) quality. Moreover, physico-chemical quality was assessed in terms of diameter by using a digital calliper, moisture content by oven-drying method at 110℃± 5℃, breaking strength by the texture analyzer, and colour by colourimeter (Chroma Meter CR-400) of the collected samples were determined. In terms of microbial quality, the results indicated contamination by E. coli (1.25-3.00 Log CFU.g^-1 in 8/14 samples), A. flavus (2.23-2.83 Log CFU.g^-1 in 12/14 samples), and A. parasiticus (1.22-2.75 Log CFU.g^-1 in 2/14 samples) as they are beyond the set limits. The diameter varied between 0.90 mm to 1.73 mm in 9/14 samples and moisture content were 10.61% to 12.65% in 13/14 samples, being within the established parameters. The samples indicated low breaking strength with levels between 6.79x10⁵ N.m^-2 to 3.75x10⁶ N.m^-2 in 11/14 samples. The result of brightness (L*) were between 53.03 to 72.14 and yellowness (b*) between 13.68 to 19.48 indices, indicating that there was no significant difference at the 5% level, respectively, although 2/14 samples had red (a*) colour values (-1.32 – +0.56). However, 4/14 samples were detected with aflatoxin B₁ (0.60-0.70 μg.kg^-1), they are within the recommended level (5 μg.kg^-1). The study underscores the need for concerted efforts to enhance production and hygiene practices to ensure consistent compliance with quality and safety standards.

This study aimed to assess the proximate composition, microbial quality, and sensory acceptability of canned Bambara beans in Ghana to determine their nutritional value and consumer perceptions. The research was conducted in Tamale in the northern region of Ghana, focusing on sensory evaluation, nutritional analysis, and consumer preferences for canned Bambara beans. The study utilized canned Bambara bean varieties sourced from local markets in Ghana. It involved sensory panels, proximate analysis, and microbial testing to evaluate the quality and safety of the canned products. Data analysis included sensory scoring, proximate composition determination, and microbial count assessments. The findings indicated positive consumer attitudes towards canned Bambara beans, emphasising their convenience, nutritional richness, and sensory appeal. Nutritional analysis revealed the nutrient content of the canned beans, highlighting their potential as a nutritious food source. Conclusions emphasised the importance of sensory attributes in consumer acceptance and women's role in producing and promoting Bambara beans. It is recommended that Increase awareness among consumers, especially women and homemakers, about the nutritional benefits and culinary versatility of canned Bambara beans. Educational campaigns highlighting canned Bambara beans' health advantages and convenience can encourage their inclusion in household diets. It is also recommended that women involved in the production and processing of Bambara beans should be supported and empowered through training, capacity building, and access to resources. Recognising the pivotal role of women in the Bambara bean value chain is essential for sustainable production practices and economic empowerment.

The operational performance of Active Pharmaceutical Ingredients (API) supply chains often suffers from significant disruptions attributed to inherent vulnerabilities. Despite theoretical discussions, empirical evidence validating these vulnerabilities remains sparse. This study endeavours to empirically substantiate the vulnerabilities arising from dynamic disruptions within the pharmaceutical supply chain. Its primary goal is to discern actionable insights that can inform the development of robust resilience strategies capable of effectively mitigating such disruptions. This study investigates vulnerabilities within the active pharmaceutical ingredient (API) supply chain in response to disruptions. Despite theoretical insights, empirical evidence validating these vulnerabilities remains limited. Through empirical analysis, this research aims to identify and elucidate the specific vulnerabilities exacerbated by dynamic disruptions in the API supply chain. The findings are intended to inform the development of resilient strategies capable of mitigating the impact of disruptions on pharmaceutical supply chains.

Fiber characteristics of Musa balbisiana, Musa paradisiaca and Musa sapientum pseudo-stalks were investigated. Fiber characteristics such as fiber length, fiber diameter, lumen width, and cell wall thickness were measured in the macerated banana pseudo-stalk by microscopy. Slenderness ratio, flexibility coefficient (%) and Runkel ratio were also determined from these microscopic measurements. Mean value of the properties evaluated for Musa sp. respectively were as follows: Fiber length- 2.96mm; Fiber diameter- 21.71µm; Lumen width- 13.55µm; Cell wall thickness- 3.86µm; Flexibility ratio- 66.35%; Runkel ratio- 0.66 and Relative fiber length- 159.12. Based on the findings of this study the Musa sp. pseudo stalk is suitable for pulp and paper production due to its high quality of fibers.

The study aimed to assess the impact of off-season vegetable farming on farmers in the Savelugu Municipality in the Northern Region. The study population consisted of all respondents to off-season vegetable farming in the Savelugu Municipality in the five selected communities in the Northern Region. A purposive sampling technique was used for a sample size of fifty (50) off-season farmers in the selected communities. An interview guide and questionnaire were used to solicit data to conclude the findings. The data derived from the questionnaire were analysed in a step-by-step thematic analysis that included reading the transcriptions several times, coding, generating codes, and reviewing and naming themes. Afterwards, the questionnaire and interview guide responses were transferred into Microsoft Excel under assigned variable names. Descriptive statistics, namely frequency, means, and percentages, were used to analyse the data. Off-season vegetable production technology can be gained by using different agro-climatic regions, maintaining or adjusting planting time, selecting varieties, and creating artificial and controlled environments through tunnels, polytene houses, glass houses, hotbeds, etc. Moreover, Off-Season vegetables helped earn income and ranked highest with an overall mean score of 1. Nearly all the trained farmers said their primary constraint was the high incidence of pests and diseases. It is evident that off-season cultivation is profitable and significantly impacts the farmers' consumption expenditure and food security status. Therefore, providing improved and modern agricultural inputs to off-season farmers is essential for rural agricultural development.

An increasing number of adverse events are raising concern in the pharmaceutical supply chain due to contaminated active pharmaceutical ingredients (APIs). Most of the active pharmaceutical ingredients are not currently under the scope of environmental regulations, despite their negative impact on human health and the environment. API's life cycle plays a significant role in identifying potential supply chain sources and determining their impact on the environment. The Covid-19 pandemic's intermittent manufacturing interruptions and the increase in the frequency of drug shortages over the past ten years have sparked worries about how resilient the world's drug supply chains are. Many clinical trials were conducted on patients with COVID-19 during the SARS-CoV-2 pandemic and resulted in millions of deaths globally by 2022.

The active pharmaceutical ingredients (API) are very critical substances for generic drugs. Any issue in the global supply chain for sourcing APIs heavily impacts generic drugs demands in the market. It is imperative to keep a close eye on the API supply in order to spot possible priorities for domestic manufacturing as well as bottlenecks in the US pharmaceutical supply chain. Most of the API's are manufactured in countries like India and China, and any issue in the manufacturing or supply of the API's may critically impact generic drug production globally. The Government and regulatory agencies must take initiatives to mitigate the risk of supply chain interruptions in the API business.

Thanks to their interesting mechanical properties, recyclability and low production costs, plant fiber-reinforced composites, derived from agricultural residues, are of particular interest to both manufacturers and scientists looking to incorporate new environmentally-friendly and biodegradable materials to replace synthetic fibers, particularly glass fibers. The growing use of these composites in fields such as the automotive, construction and building industries, and soon in aeronautics, raises concerns about the reliability of the structures with which they are manufactured. This reliability must be guaranteed at the design stage, by a good knowledge of the properties of the material used. In this case, for composites, it is necessary to know the mechanical properties of their constituents, fibers and matrix, etc. In this context, this paper focuses firstly on the economic and industrial recovery of Kenaf (K) and Date Palm (DP) fibers, and secondly on their incorporation as a reinforcing element in cementitious matrix composites, for subsequent use in non-structural applications. This research highlights the development of cementitious matrix bio-composites reinforced with this type of fiber, based on Taguchi's statistical methodology, in order to minimize the cost and number of tests. The bio-composites developed are then mechanically characterized under static loading in compression and 3-point bending after a 30-day drying period.

This experimental study was carried out to evaluate the effect of three selected pollinator-friendly practices on the African eggplant (Solanum aethiopicum) at Mankessim in the Central region of Ghana. The study focused on determining how the practices affect the production and yield of garden eggs. The three pollinator-friendly practices were the use of mulch, cassava hedgerow/marigold plants and controlled pesticide application in garden egg farms. Experimental-control group design was used. Mulching positively influenced the number of flowers, fruits and height of garden eggplants. Cassava hedgerow/marigold plants influenced the number of flowers, but had no significant effect on the number of fruits and plants’ height. There was no effect on the number of flowers, fruits, and height of garden eggplants when pesticide application was controlled or uncontrolled. No significant influence was observed in fruit weight in all treatment and control plots. The growth and yield trends observed in this research indicated that practicing the three pollinator-friendly practices may encourage flower visitors leading to effective pollination and increased yields. It is recommended that mulching be practised in garden egg farming to increase the growth and productivity of garden eggplants.

A Medical devices and pharmaceutical drugs are packaged to maintain their stability and integrity during post-production shipping and storage prior to clinical usage. During delivery and storage, the packaging may come into direct or indirect contact with the drug product or medical device, which may result in chemical interactions between the two. Packaging can be crucial for success, protection, and sale. Like other supermarket items, prescription pharmaceuticals must be packaged in a way that will meet the needs of security and provide speedy packaging, safety, identity, superiority of products, patient safety, and goods superiority. Packaging is a science and an art where many factors are taken into account, starting with the fundamental design and technology used to pack the product without any instability and providing protection, presentation and observance of manufactured goods during transportation, storage, and consumption. In order to keep the drug physiochemical, biological, and chemical stability, packaging professionals create containers that can withstand the pressures that are applied during the supply and shipping processes. Improvements in the analysis of prescription drug development had long been fixated on packaging expertise.

For conducting advanced analytics initiatives to acquire in-depth data into usage habits, regional access, sales, and promotional success, etc., unique identification of packaged pharmaceuticals will be a fantastic enabler. The main objective of this study is to prevent and reduce the production of erroneous and counterfeit drugs using the enterprise system, which has become a serious threat because it damages the reputation of legitimate drug manufacturers by trying to produce and market placebo medications that are identical to the real thing. Due to federal government procedures and priorities that frequently change over time, the majority of implementation takes time. To achieve compliance with numerous federal regulatory authorities, including drug traceability for patient safety, the pharmaceutical industry must implement a systematic procedure in an ERP environment. The goals would be to guarantee medical drug traceability and provide real-time warnings to supply chain stakeholders and regulatory bodies to maximize the benefit of integrating a drug traceability system into an ERP environment. Additionally, manufacturers are compelled to maintain product costs on the higher side due to a heavy burden of unchecked manufacturing cost spikes. As a result, innovative marketing schemes must be introduced in order to increase the reach to consumers by putting into practice successful strategies.

This study will detail the effects of computer-based graphic design on illustration in poster works. The understanding of art has evolved from ancient times to the present, giving rise to design works. With the development of the internet and computer technologies in the 20th century, the understanding of design has also changed. The impact of computer technology on the drawings in poster works will be highlighted in this study as how they began in the 1950s and 1960s and developed throughout the century. Especially in the 1990s, technological developments offered new technical possibilities to art and artists. The production of computer-aided unique designs and illustrations began. The study's evaluation portion will cover the technical aspects of the illustrations seen in the posters created by well-known historical designers. The examples presented throughout the study cover the effects of computer-based graphic design in the 20th century on the illustration in poster works.

The paper analyses the extent to which crude oil price shocks impact GDP growth, exchange rate, interest rate and inflation of an emerging oil exporting economy, Ghana. The Structural Vector Autoregressive model is used to analyse the quarterly data from 2009q1 – 2020q4. The results showed that exchange rate and GDP growth respond positively but temporal to the impulse of crude oil price. In contrast, inflation and interest rate respond negatively to crude oil price shock. Specifically, the exchange rate appreciates in the initial quarter and begins to depreciate, whereas GDP growth experiences an increase in the first two quarters and also reduces afterwards. Crude oil price shocks to the Ghanaian economy follow the conventional behaviour of the impact of crude oil on macroeconomic indicators. The positive impact of the price shock on GDP growth and exchange rate is not much reflecting the fact that Ghana is an emerging oil-producing country with low production and export level. Ghana’s prospects in the oil and gas sector should not just be a mere hoax. Policies should be directed toward petroleum exploration and production efforts since the energy transition endanger benefits for future exploitation. Policies should be implemented to attract competitive players locally and internationally in the oil industry. The shock of crude oil prices is beginning to show evidence based on this study. Therefore government must consider recognising the importance of other economic sectors in order not be become heavily dependent on oil.

There is an ongoing debate regarding how to feed Sub-Saharan Africa's fast rising population in the long run, as well as the implications for food security. To maintain food security, various strategies have been recommended, including a focus on the significance of diversifying and improving people's diets. Proposals have been tabled elsewhere with a primary focus on enhancing agricultural inputs and technology adoption in order to increase agricultural production and productivity, hence strengthening food security. The current opinion piece attempts to contribute to this debate by examining smallholder agriculture and its role to African food security. This discussion proposes a future paradigm shift toward a gendered climate-smart smallholder agriculture and food production and security conceptual framework based on the promotion and development of smallholder agriculture and food production and security. Therefore, it's predicated that the micro-livestock-centered approach can remodel smallholder agrarian households and communities toward a gender-inclusive global climate change adaptive smallholder agriculture to strengthen production, supply, and food security in Sub-Saharan Africa. For Africa, today’s predicament is to ensure food security for the anticipated rapid population expansion, while on the other hand handling an overall net adverse effect of worldwide global climate change, and increased socio-economic ills associated with gender inequality in smallholder agriculture and ensuring long-term agriculture sustainable development. The failure to address gender inequality in smallholder agriculture and food production and pontificate of global climate change effect has thrown Sub-Saharan Africa into a state of perpetual food scarcity and insecurity because of low agricultural productivity and food supply, and by force of circumstances exposing the agricultural communities and its people to extreme poverty and nutrition and food insecurity. Therefore, it's predicated that the micro-livestock-centered approach can remodel smallholder agrarian households and communities toward a gender-inclusive global climate change adaptive smallholder agriculture to strengthen production, supply, and food security in Sub-Saharan Africa. For this purpose, this discussion proposes a future paradigm shift towards a gendered climate-smart smallholder agriculture and food production and security conceptual framework hinged on the promotion and development of the micro-livestock and/or unconventional animal species sub-sector to strengthen food security on the continent. Overall, the discussion emphasizes the importance of taking immediate action to alleviate the negative effects of climate change and address gender inequality through promotion of micro livestock to assist in the development of long-term adaptation measures to maintain smallholder agricultural productivity.

One of the current issues facing humanity is ensuring sustained global food security in the face of devastating effects of climate change; this challenge is particularly pressing on the African continent. Here, I present an opinion piece identifying local animal genetic resources as "African leverage point" that provide the highest chances to cushion rural fork to climate change, enhance environmental sustainability and food security in Africa. When it comes to boosting food production, coping with climate change, or bolstering the delivery of a wide range of ecosystem services, I believe that African animal genetic resources are essential alternatives for the sustainable growth of the livestock industry and its contribution to food security. Africa needs to address the support and development of indigenous animal genetic resources in order to meet the basic food needs of more than 1 billion people, address numerous environmental issues with continental implications, and focus on more effective and resilient food systems with the greatest impact on food security. The indigenous animal resources diversity and support actions to this unique group could provide a boost in protein that is lacking to constitute healthy diets in Africa. The priorities of nonprofit organizations, foundations, governments, citizens' groups, and companies can be influenced by this leverage point in the African food system. Due to continuous food insecurity, which appears to be becoming worse with climate change and makes it even harder to accomplish the SDGs on the continent, Africa has paid a hefty price for being misled about the worth of its own animal genetic resources. To the contrary, it is highly improbable that a strategy to improve food security and rural livelihoods that undermines the utilization of indigenous animal genetic resources will be viable in long-term. If Africa makes an effort, is committed, and fully commits resources to putting indigenous animal genetic resources at the forefront of combating food insecurity and accelerating the achievement of SDGs, it can achieve more under the adverse prevailing climate change induce environmental conditions. Our personal opinion is that we would not have had the ongoing food problems, even in the face of climate change, if Africa had over the years implemented the necessary mechanisms to develop and promote local animal genetic resources. What lies ahead in terms of climate change effect on food security in Africa is anyone's guess – but whatever it is, promoting continental adapted indigenous animal genetic resources portfolio is ready to handle it. Development and promotion of African animal genetic resources should be part of a continental strategy to transform smallholder animal production by 2050, in line with the goals of achieving the SGDs, to improve rural household food security, and bringing rural economy prosperity, resilience, sustainability, and all other desired animal related food outcomes for rural healthy diets. African animal genetic resources are the most important but underutilized resource to address the issue of ongoing food insecurity. The responsible use of local animal genetic resources through climate smart animal husbandry practices also contributes to food security, rural development and increased employment opportunities. African genetic improvement programs involving indigenous animal genetic resources must be considered as regards to local agriculture and livestock development aspirations, appropriateness to local reality and livelihood security, as well as environmental friendliness. Animal agriculture will fill in the enormous gaps in the continent's food supply if this animal group receives adequate attention and is used integrated properly in crop and livestock systems which characterize smallholder farming sector in Africa. Because they have evolved over time to accommodate the various climatic conditions and environmental pressures on the continent, Africa's native animal genetic resources are particularly resilient. Indirectly, the impact of climate change offers a chance to use native animal genetics from Africa. The use of local animal genetic diversity has the potential to substantially improve Africa's food security landscape hence should be given special consideration for sociocultural, environmental, and economic aspects, and with regard for smallholder farmer-specific factors of interest. African animal genetic resources have contributed significantly to the food and nutrition security aspects of the millions of people in their communities of origin and custody in Africa. The purpose of the perception piece is to educate the reader about the fundamental mechanisms that control the use of continental animal genetic resources and how the outlook for these mechanisms can be manipulated in the future for the benefit of improving food security in Africa. The discussion provides in-depth insight into the pertinent literature in understanding the significance of local animal genetic resources in terms of their contribution to food security in Africa.

Water is essential for food security and animal agricultural productivity, but it is becoming more scarce due to climate change. The interaction between climate change and livestock water resources has received little attention from researchers, despite the significance of small-scale animal husbandry for the rural poor in Africa and the size of the changes that are anticipated to have an impact on smallholder livestock systems. Threats to livestock water are undoubtedly one of the most significant environmental issues that have impacted food security on the continent, given their links to small-scale animal husbandry and the detrimental impacts on productivity. In order to balance the negative effects of climate change scenarios for sustainable animal productivity and contribute to food security through small-scale animal agriculture, the most climate-smart and resilient agricultural water practices and technologies must be used. Changes in rainfall and a decline in the biomass available for grazing and rangelands as a result of water stress brought on by the climate would have the most severe effects. This is due to the rain-fed nature of small-scale livestock farming. The local animal genetic resources are essential for animal productivity and food security in Africa, particularly in areas where livestock water is becoming scarce owing to climate change. Research and development goals on the effects of climate change on livestock water, animal productivity, and food security may need to be reviewed if demands of vulnerable small-scale animal producers are to be successfully addressed in the future decades. It is best to use an interdisciplinary approach to comprehend the relationships between small-scale animal husbandry, food security, and climate change. By navigating the complexities of climate adaptation, small-scale livestock farmers can manage livestock water scarcity by taking adaptation measures that are in line with evolving climate impacts and associated means of implementation based on pertinent and useful knowledge that takes into account a blend of traditional and modern water science. In this paper, an effort is made to close some significant information gaps and shed light on how water-induced stress impacts small-scale animal production, which has an effect on food security.

The Adventures of Sasa and Esi is a dance theatre that takes its story reference from two short Ghanaian folktale stories the Adventures of Sasa and Esi, and the Witch of the Forest which were written by Martin Otchere Owusu and directed by Johnson Kwaku Edu and Latipher Amma Osei. The production was staged at the Amu Theatre of the Department of Theatre Arts, University of Education (UEW), Winneba from the 3^rd to the 6^th of November, 2016. Though the play was written for children it appeals to adults due to the lessons embedded in it. Both plays were adapted by the authors to include Ghanaian folk and popular contemporary choreographed dances and theatrical special effects make-up as key theatrical elements to drive the production and to project the element of spectacle. The style of presentation was naturalism and realism. The production also served as a learning platform for the cast and crew who were students in the Department of Theatre Arts, UEW as they participated in it. Through experimentation, experiences, and concept development, the directors’ style and professional background in technical theatre and creative dance heightened the element of naturalism and realism to underscore the theme of the play, understanding, and interpretation of the play.

Petroleum hydrocarbon contamination of soils has become a global concern, which is often caused by anthropogenic activities, posing serious threat to all living beings. The study for evaluation of the variability of crude oil on the physicochemical characteristics of sandy loam soil was conducted at demonstration farm, Rivers state university, Port-Harcourt, Nigeria. The Bonny light crude oil was obtained from an oil and gas production company. Uncontaminated soil was mixed with crude oil. Standard procedures were adopted for the laboratory analysis, the parameters analyzed include bulk density, total porosity, pH, available phosphorus (P), Total hydrocarbon content (THC), organic carbon, organic matter, exchangeable cation (Mg, K, Na, Ca), effective cation exchange capacity (ECEC), total exchangeable acidity (TEA), and base saturation were monitored for a period of 21 days. 10 kg of sandy loam soils were mixed with 100, 300, 500, and 700ml of crude oil while no crude oil serves as the control using plastic reactors. The reactor with 700ml of crude oil recorded the highest THC of 1734.33 mg/kg, followed by 500ml with a THC of 1601mg/kg while the control with no contamination recorded the least THC of 534.33mg/kg. However, the values of all concentrations did not meet 5000 mg/kg of Department of Petroleum Resources (2018) intervention value but exceeded the target value of 50 mg/kg. Other parameters followed same trend except porosity which decreased with increase in crude oil volume. There were significant differences at P< 0.05 except for pH, available P, and base saturation. Therefore, this study calls for the utilization of its findings for adoption of remediation on crude oil contaminated soils.